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Georg-Speyer-Haus
Institut für Tumorbiologie und experimentelle Therapie

Address Paul-Ehrlich-Straße 42-44
60596 Frankfurt am Main
Deutschland

GERiT This institution in GERiT

60596 Frankfurt am Main

Projects

Research Grants
- Current projects
  - A targeted global online intervention for pandemic-related mental health problems (COPE).
    (Applicants Adorjan, Kristina ; Schumann, Gunter )
  - Identifying and overcoming CAR T cell barriers in the colorectal carcinoma microenvironment
    (Applicants Buchholz, Christian ; Farin, Henner )
- Completed projects
Research Fellowships
- Completed projects
  - Untersuchung der Bedeutung der IKKß Untereinheit für die Enstehung kolorektaler Tumoren mit Hilfe verschiedenerr transgener und Knock-out Mäuse
    (Applicant Greten, Florian R. )
Priority Programmes
- Current projects
  - Dissecting the role of ECM-producing stromal cells in bone metastatic progression
    (Applicant Medyouf, Ph.D., Hind )
- Completed projects
Independent Junior Research Groups
- Completed projects
  - Bedeutung der IKK/NF-kB Signalkaskade für die Karzinogenese im Gastrointestinaltrakt am Beispiel des Kolons
    (Applicant Greten, Florian R. )
Research Units
- Completed projects
  - Central project
    (Applicants Farin, Henner ; Wirtz, Stefan )
  - Coordination Funds
    (Applicant Greten, Florian R. )
  - Coordination Funds
    (Applicant Greten, Florian R. )
  - FOR 2438: Cell Plasticity in Colorectal Carcinogenesis
    (Spokesperson Greten, Florian R. )
  - Functional analysis of pathways mediating intestinal stem cell plasticity
    (Applicant Greten, Florian R. )
  - The role of the EMT-inducer Zeb1 in the invasive tumor stroma during colon cancer progression
    (Applicants Brabletz, Thomas ; Farin, Henner )
  - The role of the EMT-inducer Zeb1 in the invasive tumor stroma during colon cancer progression
    (Applicants Brabletz, Thomas ; Farin, Henner )
Collaborative Research Centres
- Current projects
  - Linking the intestinal microbiome and immune mediated effects to primary tumor growth and therapy
    (Project Head Greten, Florian R. )
  - SFB 1177: Molecular and Functional Characterization of Selective Autophagy
    (Spokesperson Dikic, Ivan )
  - SFB 1292: Targeting convergent mechanisms of inefficient immunity in tumors and chronic infections
    (Spokesperson Schild, Hansjörg )
  - Targetable modifiers of T cell exclusion in KrasG12D -driven colorectal cancer
    (Project Head Greten, Florian R. )
- Completed projects
  - Crosstalk of autophagy and inflammatory signaling pathways during acute intestinal inflammation
    (Project Head Greten, Florian R. )
  - Exploring epithelial cell mitophagy as an inducer of adaptive immunity
    (Project Head Greten, Florian R. )
  - Fusionsproteine zwischen Antikoerper- oder Ligandendomaenen und bakteriellen Toxinen als experimentelle Tumortherapeutika
    (Project Head Groner, Bernd )
  - Fusionsproteine zwischen Antikörper oder Ligandendomänen und bakteriellen Toxinen als experimentelle Tumortherapeutika
    (Project Head Wels, Winfried )
  - Identification and visualization of pre-malignant epithelia during colitis-associated carcinogenesis
    (Project Head Greten, Florian R. )
  - Identifizierung von Peptidliganden für funktionelle RNA-Strukturen über Screening von Phage-display-Banken
    (Project Head Dietrich, Ursula )
  - IKKâ in macrophages and its role on tumor promotion and progression
    (Project Head Greten, Florian R. )
  - Netzwerke der Signalwandlung in Säugerzellen
    (Project Heads Dietrich, Ursula ; Strebhardt, Klaus )
  - RNA-Liganden als therapeutische Moleküle
    (Project Head Grez, Manuel )
  - Role of the phospholipid hydroxyperoxide glutathion peroxidase (PHGPx) GPx4 in murine hepatozytes and hepatocarcinogenesis
    (Project Head Greten, Florian R. )
  - ROS signaling in normal hematopoiesis
    (Project Head Grez, Manuel )
  - SFB 579: RNA-Ligand Interactions
    (Spokesperson Schwalbe, Harald )
CRC/Transregios
- Current projects
  - Alternative splicing regulation in the cardiac system by CTCF and lncRNA interaction
    (Project Heads Grote, Phillip ; Laugwitz, Karl-Ludwig )
  - TRR 267: Non-coding RNA in the cardiovascular system
    (Spokesperson Engelhardt, Stefan )
- Completed projects
  - LncRNA loci in early cardiac lineage commitment and heart function
    (Project Head Grote, Phillip )
Research Training Groups
- Current projects
  - GRK 2336: Resolution of inflammation – Mediators, signaling and therapeutic options
    (Spokesperson Brüne, Bernhard )
- Completed projects
  - GRK 1172: Research, Development and Safety of Biologicals
    (Spokesperson Pfeilschifter, Josef M. )

Subinstitutions

Institut für Biomedizinische Forschung

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