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Philipps-Universität Marburg
Fachbereich Pharmazie
Institut für Pharmazeutische Chemie

Address Marbacher Weg 6-10
35037 Marburg
Deutschland

GERiT This institution in GERiT

35037 Marburg

Projects

Research Grants
- Current projects
- Completed projects
Research Fellowships
- Completed projects
  - Activation mechanisms of Class F GPCRs – from structural understanding to novel therapeutics
    (Applicant Schihada, Hannes )
  - Synthese von Strukturanaloga sowie von affinity labels des Naturstoffs Salicylihalamid A zur Untersuchung von Struktur-Wirkungsbeziehungen sowie zur Charakterisierung der Interaktion von Salicyclihalamiden mit ihrem biologischen Target
    (Applicant Diederich, Wibke Elisabeth )
Priority Programmes
- Current projects
  - Machine-Learning-guided chemical space exploration: automatic creation and navigation of ultra-large open-source molecular libraries
    (Applicant Kolb, Peter )
- Completed projects
  - Directed evolution to understand enzyme function of almost protein independent bacterial RNase P RNA versus largely protein-dependent archaeal RNase P RNA
    (Applicant Hartmann, Roland K. )
  - Structural and functional aspects of the small riboregulator 6S RNA
    (Applicant Hartmann, Roland K. )
Research Units
- Completed projects
  - Metallhybridenzyme zur Katalyse von Click-Chemie-Reaktionen
    (Applicants Klebe, Gerhard ; Koert, Ulrich )
  - Perturbance of enzyme function by blocking dimer interface formation: Novel route to specific antibiotics
    (Applicant Klebe, Gerhard )
Independent Junior Research Groups
- Current projects
  - Decoding the conformational diversity of heterotrimeric G proteins that defines receptor-specific signaling
    (Applicant Schihada, Hannes )
- Completed projects
  - Understanding and predicting the specificity of small molecule protein interactions
    (Applicant Kolb, Peter )
Heisenberg Professorships
- Completed projects
  - In silico tailoring of ligands for G protein-coupled receptors: designing selectivity, efficacy and molecular structures
    (Applicant Kolb, Peter )
Heisenberg Grants
- Completed projects
  - In silico tailoring of ligands for G protein-coupled receptors: designing selectivity, efficacy and molecular structures
    (Applicant Kolb, Peter )
Major Research Instrumentation
- Completed projects
  - 400 MHz NMR-Konsole
WBP Fellowship
- Completed projects
  - In silico prediction of small molecule ligands for class Frizzled GPCRs and investigation of the structural basis of FZD signalling
    (Applicant Scharf, Magdalena M. )
Collaborative Research Centres
- Current projects
  - Mechanisms and regulation of Ebola virus RNA synthesis
    (Project Heads Becker, Stephan ; Biedenkopf, Nadine ; Hartmann, Roland K. )
- Completed projects
  - High-throughput identification of conserved structures in mRNAs
    (Project Head Weigand, Julia Erika )
CRC/Transregios
- Completed projects
  - Chemoinformatics, Medicinal Chemistry & Peptidomimetics
    (Project Heads Diederich, Wibke Elisabeth ; Kolb, Peter ; Vazquez, Olalla )
Research Training Groups
- Current projects
  - GRK 2355: Regulatory networks in the mRNA life cycle: from coding to noncoding RNAs
    (Spokesperson Sträßer, Katja )
  - GRK 2937: Nucleotide Metabolism in Microbes
    (Spokesperson Graumann, Peter )
- Completed projects
  - GRK 541: Protein Function at the Atomic Level
    (Spokesperson Buckel, Wolfgang )
International Research Training Groups
- Completed projects
  - GRK 1384: Enzymes and Multienzyme Complexes Acting on Nucleic Acids
    (Spokesperson Friedhoff, Peter )

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