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Institution
Universitätsklinikum Ulm
Institut für Experimentelle und Klinische Pharmakologie,Toxikologie und Naturheilkunde
Address
Albert-Einstein-Allee 11
89081 Ulm
Deutschland
GERiT
This institution in GERiT
89081 Ulm
Projects
Research Grants
Current projects
Inhibition of bacterial protein toxins, in particular the toxins of Clostridioides difficile, by factors and cleavage products of the human complement system
(Applicants
Barth, Holger
;
Huber-Lang, Markus
)
Molecular, Biochemical and Functional Analysis of Shiga Toxin and Subtilase Cytotoxin Subunits of Enterohemorrhagic Escherichia coli
(Applicants
Barth, Holger
;
Schmidt, Herbert
)
Completed projects
Crossing Barriers with bio-based Therapeutics
(Applicant
Otte, Ph.D., Kerstin
)
Identification and characterization of cell membrane receptors of binary actin-ADP-ribosylating toxins
(Applicant
Aktories, Klaus
)
Molekulare Mechanismen der Interaktion des Tumorsuppressors Merlin mit Rho-GTPasen / Aufklärung von Neurofibromatose (NF-)relevanten Signaltransduktionswegen und Biomarkern mit Protein Mikroarrays
(Applicants
Gierschik, Peter
;
Joos, Thomas
)
Probing temporal sequences and molecular mechanisms of transcription initiation by single molecule fluorescence microscopy in living eukaryotic cells
(Applicant
Gebhardt, Christof
)
Role of peptidyl-prolyl cis/trans-isomerases (PPlases) during uptake of binary bacterial toxins into the cytosol of mammalian cells
(Applicant
Barth, Holger
)
Structure-function analysis of large clostridial cytotoxins
(Applicant
Aktories, Klaus
)
Virusinduzierte Regulation der Genexpression infizierter Wirtszellen
(Applicant
Burysek, Ladislav
)
Priority Programmes
Completed projects
Modification of actin by bacterial protein toxins and effectors
(Applicant
Barth, Holger
)
SPP 312: GTPasen als zentrale Regulatoren zellulärer Funktionen
(Spokesperson
Gierschik, Peter
)
Collaborative Research Centres
Current projects
Biohybrid transporters for cell type-specific delivery and controlled release of pharmacologically active peptides
(Project Heads
Barth, Holger
;
Michaelis, Jens
)
Cellular and molecular responses to trauma-induced damage of the distal respiratory epithelium
(Project Heads
Barth, Holger
;
Frick, Manfred
)
Endogenous peptides as novel inhibitors of the Bordetella pertussis toxin
(Project Heads
Barth, Holger
;
Ernst, Katharina
)
Synthesis of peptide and protein biohybrids with improved features
(Project Heads
Barth, Holger
;
Otto, Markus
;
Weil, Tanja
)
Completed projects
ADP-Ribosylierung von Aktin durch bakterielle Toxine
(Project Heads
Aktories, Klaus
;
Barth, Holger
)
Cell type-selective carriers for targeted pharmacological inhibition of Rho-/actin-dependent leukocyte recruitment into the alveolar space after blunt chest trauma
(Project Heads
Barth, Holger
;
Weil, Tanja
)
Funktionelle Bedeutung des konstitutiv aktiven viralen Chemokinrezeptorhomologs pUS28 in Zytomegalievirus-infizierten Gefäßwandzellen
(Project Heads
Gierschik, Peter
;
Mertens, Thomas
)
Mechanistic basis of CLL resistance to targeted tumor therapy in a pathophysiologically relevant cellular context: role of Rho GTPases and phospholipase C-y2
(Project Head
Gierschik, Peter
)
Molekulare Mechanismen der Aktivierung von Rho-GTPase Rac2 und ihres Effektors Phospholipase C-ß2 in myeloischen Zellen
(Project Head
Illenberger, Daria
)
Molekulare Mechanismen der Signaltransduktion der Chemokinrezeptoren CCR2a und CCR2b: Bedeutung von rezeptorassoziierten Signalmolekülkomplexen
(Project Head
Möpps, Barbara
)
Regulation der gerichteten Migration und Invasion humaner Pankreaskarzinomzellen
(Project Heads
Giehl, Klaudia
;
Gierschik, Peter
)
Regulation der Phospholipase C-Gamma2 durch Rac-GTPasen: Molekulare Mechanismen und physiologische Bedeutung
(Project Heads
Gierschik, Peter
;
Nienhaus, Gerd Ulrich
)
Major Research Instrumentation
Completed projects
Hybrid-FT(Fouriertransformations)-Massenspektrometer mit eindimensionalem, splitfreiem Nano-Ultrahochdruck-Flüssigkeitschromatographie-System
Research Training Groups
Completed projects
GRK 460: Diagnostic and Therapeutic Concepts in Molecular Medicine
(Spokesperson
Lehmann-Horn, Frank
)
GRK 1041: Molecular Diabetology and Endocrinology in Clinical Medicine
(Spokesperson
Böhm, Bernhard Otto
)
GRK 2203: Micro- and nano-scale sensor technologies for the lung
(Spokesperson
Ortmanns, Maurits
)
Graduate Schools
Completed projects
GSC 270: International Graduate School in Molecular Medicine Ulm
(Spokesperson
Kühl, Michael
)
Additional Information
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