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Institution
Universitätsklinikum Carl Gustav Carus
an der Technischen Universität Dresden
Medizinische Klinik und Poliklinik III
Address
Fetscherstraße 74
01307 Dresden
Deutschland
GERiT
This institution in GERiT
01307 Dresden
Projects
Research Grants
Current projects
Investigating skeletal resorption as a tissue-specific mechanism promoting skeletal tissue integration in the axolotl (Ambystoma mexicanum).
(Applicant
Aires, Ph.D., Rita
)
Signal scaling during limb regeneration of different sized animals
(Applicants
Friedrich, Benjamin M.
;
Sandoval-Guzmán, Ph.D., Tatiana
)
The role of mTORC1 in mediating thyroid hormone actions on bone and bone cell metabolism
(Applicant
Brinkmann, Franziska
)
Completed projects
Charakterisierung von Aldosteron-stimulierenden Faktoren im Fettgewebe als möglicher direkter Zusammenhang zwischen Übergewicht und Bluthochdruck
(Applicant
Ehrhart-Bornstein, Monika
)
Die Bedeutung der Toll-like Rezeptoren bei der Sepsis-vermittelten Nebennierenstörung
(Applicants
Bornstein, Ph.D., Stefan R.
;
Zacharowski, Ph.D., Kai
)
Effects of heart rate variability (HRV) biofeedback on HRV and immune response in patients with panic disorder
(Applicant
Petrowski, Katja
)
Inseltransplantation in einem oxygenierten bioartifiziellen Pankreas
(Applicant
Ludwig, Barbara
)
Leptin und die Funktion der Hypothalamus-Hypophysen-Nebennieren Achse. Neue Ansätze zur Therapie der Adipositas
(Applicant
Scherbaum, Werner
)
lnterleukin-6- Signaltransduktion bei systemischem Lupus erythematodes
(Applicant
Aringer, Martin
)
Mechanismen der rheumatoiden Knochendestruktion: Bedeutung der synovialen Fibroblasten und der Osteoklasten
(Applicant
Hummel, Klaus-Matthias
)
Mechanisms of bone dynamics during fingertip regeneration in axolotl, mouse and human.
(Applicant
Sandoval-Guzmán, Ph.D., Tatiana
)
Modulation endothelialer Reparaturvorgänge nach selektiver Endothelzellschädigung der Mausniere durch endotheliale Vorläuferzellen
(Applicant
Hohenstein, Bernd
)
Molekulare und zelluläre Mechanismen der intra-adrenalen Regulation der Nebennierenfunktion
(Applicant
Bornstein, Ph.D., Stefan R.
)
Regulation des Lipoproteinmetabolismus beim Metabolischen Syndrom - In-vivo-Messung mittels Stabilisotopentechnik
(Applicant
Julius, Ulrich
)
The effect of glucocorticoid excess on the osteohematopoietic niche
(Applicants
Baschant, Ulrike
;
Henneicke, Ph.D., Holger
)
Understanding the systemic consequences of disrupted steroidogenesis
(Applicant
Krone, Nils
)
Research Fellowships
Completed projects
7M-Multiomic Multiscale and Multifidelity Modeling via Machine Learning: Application to Diagnosis and to Macrovascular and Microvascular complications in NAFLD.
(Applicant
Perakakis, Nikolaos
)
Mechanismen und therapeutische Beeinflußbarkeit der oxidativen Schädigung und endothelialen Dysfunktion bei Hyperhomocyst(e)inämie
(Applicant
Weiss, Norbert
)
Untersuchung zur molekularen Pathogenese des Adrenogenitalen Syndroms durch P450 Oxidoreduktasemangel
(Applicant
Krone, Nils
)
Clinical Research Units
Completed projects
Central administration: analytical, clinical and model systems platforms
(Applicants
Bornstein, Ph.D., Stefan R.
;
Chavakis, Triantafyllos
;
Eisenhofer, Ph.D., Graeme
)
Chromaffin progenitor cells in adrenal tissue formation
(Applicants
Androutsellis-Theotokis, Ph.D., Andreas
;
Ehrhart-Bornstein, Monika
)
Engraftment, function and beta cell regulation in the adrenal transplant model
(Applicants
Ludwig, Barbara
;
Morawietz, Henning
)
Genotype-steroidogenic phenotype relationships in patients with aldosteronomas and in experimental cell model systems
(Applicant
Lenders, Ph.D., Jacques W.M.
)
Hypoxia and MYC/MAX signaling pathways in chromaffin tumourigenesis
(Applicant
Eisenhofer, Ph.D., Graeme
)
Immune mechanisms and potential therapeutic interventions for sepsis-induced adrenal gland inflammation
(Applicants
Bornstein, Ph.D., Stefan R.
;
Kanczkowski, Waldemar
;
Zacharowski, Ph.D., Kai
)
KFO 252: Microenvironment of the Adrenal in Health and Disease
(Spokesperson
Bornstein, Ph.D., Stefan R.
)
Research Units
Current projects
Defining the role of the iron-sensor Tfr2 in ossification processes
(Applicant
Baschant, Ulrike
)
FOR 5146: Defining the osteohepatic axis in the context of iron homeostasis - FerrOs
(Spokesperson
Rauner, Martina
)
Completed projects
Leptin und die Funktion der Hypothalamus-Hypophysen-Nebennieren Achse. Neue Ansätze zur Therapie der Adipositas
(Applicant
Scherbaum, Werner
)
Collaborative Research Centres
Completed projects
Chromaffin progenitor cells from the adrenal medulla
(Project Heads
Bornstein, Ph.D., Stefan R.
;
Ehrhart-Bornstein, Monika
)
Hes3+ cells into brain tissue
(Project Head
Androutsellis-Theotokis, Ph.D., Andreas
)
Interaction of FLT3 and CXCR4 in hematopoietic stem cells
(Project Heads
Brenner, Sebastian
;
Thiede, Christian
)
Niche targeting to increase graft size for allogeneic hematopoietic stem cell transplantation
(Project Heads
Ehninger, Gerhard
;
Illmer, Thomas
;
Thiede, Christian
)
CRC/Transregios
Current projects
Adrenal stem cells under homeostatic and stress conditions
(Project Heads
Andoniadou, Ph.D., Cynthia L.
;
Bornstein, Ph.D., Stefan R.
;
Schedl, Andreas
;
Steenblock, Charlotte
)
Biological treatment of adrenal insufficiency by encapsulated xenogeneic adrenal cells
(Project Heads
Bornstein, Ph.D., Stefan R.
;
Ludwig, Barbara
)
Cell-specific activation of glucocorticoids resolves inflammatory arthritis and prevents bone resorption
(Project Heads
Baschant, Ulrike
;
Tuckermann, Jan
)
Central Task
(Project Head
Bornstein, Ph.D., Stefan R.
)
Comprehensive characterization of patients with inflammatory bone disease with serological profiling and imaging
(Project Heads
Hofbauer, Lorenz C.
;
Mirtschink, Peter
;
Schett, Georg
;
Tsourdi, Elena
)
HIF-MYC/MAX pathway in neural-crest derived catecholamine producing tumours: Identification of a metabolic fingerprint related to tumour aggressiveness
(Project Heads
Bechmann, Nicole
;
Eisenhofer, Ph.D., Graeme
;
Klink, Barbara
;
Lenders, Ph.D., Jacques W.M.
)
Pathophysiology and advanced approaches for subtyping in primary aldosteronism
(Project Heads
Eisenhofer, Ph.D., Graeme
;
Lenders, Ph.D., Jacques W.M.
;
Williams, Ph.D., Tracy Ann
)
Patient cohorts and biobanks
(Project Heads
Eisenhofer, Ph.D., Graeme
;
Fassnacht, Martin
;
Pamporaki, Ph.D., Christina
;
Reincke, Martin
)
Regulated cell death in adrenal inflammation and septic shock
(Project Heads
Bornstein, Ph.D., Stefan R.
;
Kanczkowski, Waldemar
;
Linkermann, Andreas
)
The role of the iron regulator transferrin receptor 2 in infection and bone
(Project Heads
Baschant, Ulrike
;
Scholtysek, Carina
)
TRR 205: The Adrenal: Central Relay in Health and Disease
(Spokesperson
Bornstein, Ph.D., Stefan R.
)
Completed projects
Analysis of inflammatory circuits during the Instant Blood-Mediated Inflammatory Reaction
(Project Heads
Chavakis, Triantafyllos
;
Ludwig, Barbara
;
Waskow, Claudia
)
Immunogenicity of islets of different clinically relevant sources in a preclinical humanized mouse model
(Project Heads
Klymiuk, Nikolai
;
Linkermann, Andreas
;
Ludwig, Barbara
;
Waskow, Claudia
)
Optimizing porcine islet macroencapsulation for the treatment of patients with insulin-dependent diabetes mellitus
(Project Heads
Bornstein, Ph.D., Stefan R.
;
Brendel, Mathias
;
Ludwig, Barbara
;
Peakman, Ph.D., Mark
;
Sancho Zapatero, Rocio
;
Welzel, Petra B.
)
International Research Training Groups
Current projects
GRK 2251: Immunological and Cellular Strategies in Metabolic Disease (ICSMD)
(Spokesperson
Bornstein, Ph.D., Stefan R.
)
GRK 2773: Risks and Pathomechanisms of Affective Disorders
(Spokesperson
Bauer, Michael
)
Graduate Schools
Completed projects
GSC 97: Dresden International Graduate School for Biomedicine and Bioengineering (DIGS-BB)
(Spokesperson
Rödel, Gerhard
)
Clusters of Excellence
Completed projects
EXC 168: Regenerative Therapies - From Cells to Tissues to Therapies: Engineering the Cellular Basis of Regeneration
(Spokespersons
Bonifacio, Ph.D., Ezio
;
Brand, Michael
;
Calegari, Ph.D., Federico
;
Tanaka, Ph.D., Elly Margaret
)
Additional Information
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