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Institution
Universitätsklinikum Essen
Klinik für Endokrinologie und Stoffwechselerkrankungen
Address
Hufelandstraße 55
45147 Essen
Deutschland
GERiT
This institution in GERiT
45147 Essen
Projects
Research Grants
Current projects
Promoting Excellence in Medicine: The University Medicine Essen Clinician Scientist Academy (UMEA)
(Applicant
Führer-Sakel, Dagmar
)
The role of guanine-quadruplexes in cell type-specific transcriptional and post-transcriptional regulation of thyroid hormone receptors TRalpha1 and TRalpha2
(Applicant
Hönes, Georg Sebastian
)
Completed projects
Analysen zur Funktion des Schilddrüsenhormon-transportierenden Proteins Oatp1c1 mittels gendefizienter Mausmutanten
(Applicant
Heuer, Heike
)
Analysis of mice mutants deficient in the thyroid hormone transporter MCT8
(Applicant
Heuer, Heike
)
Charakterisierung der Thyroxin-Bindungsstelle des thyroxinbindenden Globulins und Struktur-Funktions-Korrelation mit den Serin-Protease-Inhibitoren
(Applicant
Janßen, Onno E.
)
Generation and characterization of a mouse model for ALK-positive anaplastic thyroid carcinoma
(Applicant
Möller, Lars
)
Molekulare Diskrimination kalter Schilddrüsenknoten - Relevanz des Onkogens DJ-1 für die follikuläre Schilddrüsenkarzigonese
(Applicant
Führer-Sakel, Dagmar
)
Which is the impact of the hinge region of glycoprotein hormone receptors on negative ooperativity, dimerization and G protein coupling profiles?
(Applicant
Jäschke, Holger
)
Independent Junior Research Groups
Completed projects
Proteomanalyse und Molekularbiologie des "kalten" Schilddrüsenknotens
(Applicant
Führer-Sakel, Dagmar
)
Research Fellowships
Completed projects
Generation and characterization of murine models to study the molecular mechanisms of G protein signaling in the thyroid and their role in thyroid diseases
(Applicant
Jäschke, Holger
)
Immune response in anaplastic thyroid carcinoma after MAPK pathway inhibition
(Applicant
Tiedje, Vera
)
Regulators of thyroid hormone action on adult hippocampal neurogenesis
(Applicant
Mayerl, Steffen
)
Ursachen der Schilddrüsenhormonresistenz bei Fehlen von Schilddrüsenhormonrezeptor-Mutationen
(Applicant
Möller, Lars
)
Wirkungen von Schilddrüsenhormonen auf die Proliferation und Differenzierung cerebellarer Neurone der Maus in Primärkultur
(Applicant
Heuer, Heike
)
Priority Programmes
Completed projects
Integrated-OMICs analyses to identify pathways associated with thyroid hormones and their molecular regulators: Screening for new markers to assess thyroid hormone action
(Applicants
Brabant, Georg
;
Friedrich, Nele
;
Führer-Sakel, Dagmar
;
Völker, Uwe
)
Molecular mechanisms of age-dependent thyroid hormone action on target tissues
(Applicant
Führer-Sakel, Dagmar
)
Non-classical thyroid hormone action mediated by thyroid hormone receptor alpha and beta
(Applicant
Möller, Lars
)
Oral thyroxine resistance revisited - how thyroxine transpasses the gut-blood barrier
(Applicants
Führer-Sakel, Dagmar
;
Schweizer, Ulrich
)
Role of the murine thyroid hormone transporters Mct8 and Oatp1c1 in skeletal muscle, cardiovascular and metabolic system
(Applicants
Heuer, Heike
;
Mittag, Jens
)
Role of Tight Junctions in Gallstone Formation under Hypothyroidism
(Applicant
Zwanziger, Denise
)
SPP 1629: THYROID TRANS ACT - Translation of Thyroid Hormone Actions beyond Classical Concepts
(Spokesperson
Führer-Sakel, Dagmar
)
SPP1629 coordination project
(Applicants
Biebermann, Heike
;
Brix, Klaudia
;
Führer-Sakel, Dagmar
)
The tissue-specific role of the murine thyroid hormone transporters Mct8 and Mct10
(Applicant
Heuer, Heike
)
CRC/Transregios
Current projects
Central administration of the collaborative research centre (ADM)
(Project Head
Führer-Sakel, Dagmar
)
Hepatic TH signalling in acute and chronic liver injury
(Project Heads
Lange, Christian
;
Möller, Lars
;
Zwanziger, Denise
)
Integrated Research Training Group (iRTG)
(Project Heads
Heuer, Heike
;
Kühnen, Peter
;
Müller-Fielitz, Helge
;
Opitz, Robert
)
Local TH action in acute and chronic ischaemic heart disease
(Project Heads
Führer-Sakel, Dagmar
;
Lorenz, Kristina
;
Möller, Lars
)
Local TH transport and action in ischaemic brain injury
(Project Heads
Führer-Sakel, Dagmar
;
Kleinschnitz, Christoph
;
Langhauser, Friederike
)
Role of local TH action in epilepsy
(Project Head
Mayerl, Steffen
)
TH transporters at brain barriers
(Project Heads
Heuer, Heike
;
Schwaninger, Markus
)
TH transporters in myelin formation and regeneration
(Project Heads
Engel, Daniel Robert
;
Heuer, Heike
)
TRR 296: Local control of TH action (LocoTact)
(Spokesperson
Führer-Sakel, Dagmar
)
Visual data analysis platform for predesigned workflows - Research data management (INF)
(Project Heads
Engel, Daniel Robert
;
Führer-Sakel, Dagmar
;
Köster, Johannes
;
Mittag, Jens
;
Opitz, Robert
;
Rehwald, Stephanie
)
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