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Institution
Uniklinik Köln
Klinik und Poliklinik für Kinder- und Jugendmedizin
Address
Kerpener Straße 62
50937 Köln
Deutschland
GERiT
This institution in GERiT
50937 Köln
Projects
Research Fellowships
Completed projects
Experimental Local Therapy in High-Risk Neuroblastoma
(Applicant
Fischer, Janina
)
Identifikation und Charakterisierung neuer Liganden für Fibrillin durch Screenen der Propeptide aller Mitglieder aus der Familie der humanen TGFß Wachstumsfaktoren
(Applicant
Sengle, Gerhard
)
Skelettentwicklung und Biomineralisierung
(Applicant
Brachvogel, Bent
)
TGF-beta inhibition to promote lung growth in mechanically ventilated newborn mice: a novel strategy to prevent ventilator-induced lung injury
(Applicant
Alejandre Alcázar, Ph.D., Miguel Angel
)
The role of resident lung mesenchymal stromal cells in the pathogenesis of bronchopulmonary dysplasia (BPD).
(Applicant
Mizik, Ph.D., Ivana
)
Research Grants
Current projects
Adipose tissue-lung axis: Early life obesity drives lung stem cell aging and predisposes to the development of idiopathic pulmonary fibrosis (IPF)
(Applicants
Alejandre Alcázar, Ph.D., Miguel Angel
;
Lehmann, Mareike
)
Biomarkers and outcome PREdictors of paediatriC nephrotIc syndrome: a genetic, transcriptomic and SEcretome multiomics study
(Applicants
Liebau, Max Christoph
;
Schaefer, Franz
)
Controlling collagen deposition by fibroblasts in cutaneous fibrosis by targeting TANGO1 function
(Applicants
Krieg, Thomas
;
Sengle, Gerhard
)
Early nutritional intervention with docosahexaenoic acid and choline to prevent susceptibility towards arterial hypertension and aggravated course of glomerulonephritis in intrauterine growth restricted rats
(Applicants
Nüsken, Kai-Dietrich
;
Nüsken, Eva
)
European Natural History Study and search for novel biomarkers in GNAO1 associated disorders
(Applicant
Thiel, Moritz
)
Investigation of the molecular mechanisms of premature lung aging and enhanced susceptibility for chronic lung diseases in a postnatal stress model
(Applicants
Alejandre Alcázar, Ph.D., Miguel Angel
;
Schumacher, Björn
)
Mitochondrial respiratory chain dysfunction and its consequences for metabolite-dependent skeletal differentiation and ageing processes
(Applicant
Brachvogel, Bent
)
Molecular pathogenesis of autosomal recessive polycystic kidney disease (ARPKD): Fibrocystin as a regulator of cell metabolism and mitochondrial function
(Applicant
Liebau, Max Christoph
)
Preclinical evaluation of perinatal therapeutic approaches for autosomal recessive polycystic kidney disease (ARPKD)
(Applicant
Liebau, Max Christoph
)
The role of Itgam+ pulmonary macrophage populations in the pathogenesis and long-term effects of bronchopulmonary dysplasia.
(Applicant
Mizik, Ph.D., Ivana
)
Completed projects
Bedeutung der hypoxisch bedingten intrauterinen Leptinsynthese für das postnatale Leben
(Applicant
Dötsch, Jörg
)
Disruption of the feto-maternal transfer zone via maternal obesity
(Applicant
Appel, Sarah
)
Extracellular matrix - immune system interaction
(Applicant
Brachvogel, Bent
)
Extracellular regulation of growth factors of the transforming growth factor beta superfamily by fibrillin
(Applicant
Sengle, Gerhard
)
Functional Role of Klf4 in Alveolarization and Ventilation-Induced Lung Injury of Newborn Mice
(Applicant
Alejandre Alcázar, Ph.D., Miguel Angel
)
Genidentifizierung und Molekulare Charakterisierung eines Gens für "Medullary Cystic Kidney Desease" Typ 1 (MCKD1)
(Applicant
Hoppe, Bernd
)
Genotyp-abhängiges Therapieansprechen auf Pyridoxalphosphat (Vitamin B 6) bei Patienten mit primärer Hyperoxalurie Typ I (PH I)
(Applicant
Hoyer-Kuhn, Heike-Katharina
)
Identifizierung von microRNA Netzwerken in gesunden hämatopoetischen Stamm- und Vorläuferzellen und leukämischen Stammzellen der akuten myeloischen Leukämie
(Applicant
Landgraf, Pablo
)
Impact of different causes of intrauterine growth restriction in the rat on early neurodevelopment and long-term neurocognitive outcome
(Applicant
Nüsken, Kai-Dietrich
)
Improved perinatal glucose metabolism and the effect on the offspring's hippocampus in the mouse
(Applicants
Appel, Sarah
;
Hucklenbruch-Rother, Eva
)
Mechanismen der nomalen und pathologischen Biomineralisierung
(Applicant
Brachvogel, Bent
)
miRNAs - novel regulators of endochondral ossification
(Applicant
Brachvogel, Bent
)
Role of Integrin-linked kinase in skin homeostasis and carcinogenesis
(Applicant
Wickström, Ph.D., Sara A.
)
Rolle von Hypoxie und Leptin in der Entstehung der plazentaren Entzündungsreaktion bei Präeklampsie
(Applicants
Dötsch, Jörg
;
Schnare, Markus
;
Strick, Reiner
)
Untersuchungen zu Hirnreifungs- und Regulationsstörungen bei Frühgeborenen unter Verwendung der 1H-NMR-Spektroskopie
(Applicant
von Gontard, Alexander
)
Research Units
Current projects
Collagen VI assembly and function in musculoskeletal disorders
(Applicants
Paulsson, Mats
;
Schiavinato, Ph.D., Alvise
)
Coordination Funds
(Applicant
Brachvogel, Bent
)
Disease mechanisms and therapeutic interventions in non-classical osteogenesis imperfecta
(Applicants
Semler, Jörg Oliver
;
Zaucke, Frank
)
FOR 2722: Novel molecular determinants for musculoskeletal extracellular matrix homeostasis – a systemic approach (M2)
(Spokesperson
Brachvogel, Bent
)
Metabolically active hormones derived from the musculoskeletal system
(Applicants
Dötsch, Jörg
;
Hucklenbruch-Rother, Eva
;
Sengle, Gerhard
)
Microenvironmental regulation of muscle homeostasis and its role in musculoskeletal diseases
(Applicants
Hammerschmidt, Matthias
;
Sengle, Gerhard
)
Mitochondrial dysfunction in cartilage and its consequences for extracellular matrix and joint homeostasis
(Applicants
Brachvogel, Bent
;
Etich, Julia
)
Collaborative Research Centres
Completed projects
Extracellular fibrillin microfibrils as multifunctional scaffolds integrating growth factor signalling in the skin
(Project Head
Sengle, Gerhard
)
Renal inflammation after intrauterine growth restriction: mechanisms of perinatal programming and reprogramming
(Project Heads
Dötsch, Jörg
;
Plank, Christian
)
Role of pericytes in skin wound healing
(Project Head
Brachvogel, Bent
)
Structure-function relationships of Hsp47/SERPINH1 and its role in skin fibrosis
(Project Heads
Baumann, Ulrich
;
Sengle, Gerhard
;
Zaucke, Frank
)
Clinical Research Units
Current projects
Context-dependent transcriptional programs governed by YAP and TAZ and their nuclear control mechanisms in FSGS
(Applicants
Habbig, Sandra
;
Schermer, Bernhard
)
KFO 329: Disease pathways in podocyte injury – from molecular mechanisms to individualized treatment options
(Spokesperson
Benzing, Thomas
)
MCD/FSGS registry and digital nephropathology
(Applicants
Grundmann, Franziska
;
Johannis, Wibke
;
Weber, Lutz T.
)
CRC/Transregios
Current projects
Animal models
(Project Heads
Quast, Christine
;
Sengle, Gerhard
;
Zimmer, Sebastian
)
Dysregulated extracellular signalling pathways in aortic aneurysm formation in Marfan syndrome and related disorders
(Project Head
Sengle, Gerhard
)
Integrated Research Training Group Aortic Disease
(Project Heads
Haendeler, Judith
;
Hörr, Verena
;
Jansen, Felix
;
Mons, Ute
;
Quast, Christine
;
Sengle, Gerhard
)
Research Training Groups
Completed projects
GRK 750: Vascular Injury in Heart and Kidney: Pathogenesis and Diagnostics
(Spokesperson
Goppelt-Strübe, Margarete
)
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