Universitätsklinikum Tübingen
Medizinische Universitätsklinik
Abteilung Innere Medizin I
Address
Otfried-Müller-Straße 10
72076 Tübingen
Deutschland
GERiT
This institution in GERiT
72076 Tübingen
Projects
Research Grants
Current projects
A multicentric translational clinical study on the role of the oro-intestinal microbiome in pancreatic cancer chemotherapy
(Applicant
Stein-Thöringer, Christoph Karl
)
Identification of T cell differentiation drivers towards exhaustion and anergy via multiplexed interventions
(Applicant
Claassen, Ph.D., Manfred
)
Modified peptides as potential new antibiotics versus multiresistent problem strains
(Applicant
Malek, Nisar Peter
)
On the pathophysiology of Enterococcus as intestinal commensal in the development of gut graft-versus-host disease
(Applicant
Stein-Thöringer, Christoph Karl
)
Completed projects
Herstellung und präklinische Evaluation neuer Generationen von Sendai Virus Vektoren für die Somatische Gentherapie
(Applicant
Bitzer, Michael
)
Identification, isolation and characterisation of novel antimicrobial peptides from human tissue as well as the development of therapeutically applicable lead structures
(Applicant
Malek, Nisar Peter
)
Identifizierung des molekularen Mechanismus, durch den p27kip1 die Differenzierung von Kolonkarzinomen beeinflusst
(Applicant
Malek, Nisar Peter
)
Identifizierung eines Signaltransduktionsweges der zum Abbau des Zellzyklusinhibitors p27 beim Eintritt in den Zellteilungszyklus führt
(Applicant
Malek, Nisar Peter
)
Inhibition of angiogenesis by gene therapeutic expression of endostatin as a molecular therapy for hepatocellular carcinoma (HCC)
(Applicant
Graepler, Florian
)
Molekulare Therapie des Hepatozellulären Karzinoms (HCC) durch gentherapeutisch vermittelte Expression des Angiogenese-Inhibitors Endostatin
(Applicant
Schuppan, Detlef
)
The role of centrosome duplication errors in the formation of hepatocellular carcinomas
(Applicant
Malek, Nisar Peter
)
Clinical Research Units
Completed projects
Kontrolle proteolytischer Mechanismen zur Aufrechterhaltung der Gewebshomöostase in Leberepithelien
(Applicant
Malek, Nisar Peter
)
Research Fellowships
Completed projects
Investigation of microbiome-host interactions in intestinal graft-versus-host disease as a clinical relevant condition of microbially triggered immune system modulation.
(Applicant
Stein-Thöringer, Christoph Karl
)
Untersuchung der Funktion und Wirkungsweise der Transkriptionsfaktoren HNF3a und GATA-4 auf die Chromatinstruktur im Rahmen der Leberentwicklung
(Applicant
Wüstefeld, Torsten
)
Collaborative Research Centres
Completed projects
Epigenetic reprogramming: innovative concept to overcome resistance to therapy in gastrointestinal oncology
(Project Head
Bitzer, Michael
)
Hepatic progenitor cells as a source for cell transplantation
(Project Head
Malek, Nisar Peter
)
Research Units
Completed projects
FOR 2314: Targeting therapeutic windows in essential cellular processes for tumor therapy
(Spokesperson
Zender, Lars
)
Targeting oncogene-driven translation and integrated stress response signaling in Cancer
(Applicants
Malek, Nisar Peter
;
Wiegering, Armin
)
CRC/Transregios
Completed projects
Combinatorial targeting of epigenetic mechanisms in liver cancer
(Project Heads
Bitzer, Michael
;
Dauch, Ph.D., Daniel
)
Control of centrosome regulation by SCF ubiquitin ligases as a pathophysiological factor in hepatocarcinogenesis
(Project Head
Malek, Nisar Peter
)
Defining the role of Notch signalling in the formation of Cholangiocarcinoma
(Project Head
Malek, Nisar Peter
)
Platelet aggregation and activity in steatosis-HCC
(Project Heads
Claassen, Ph.D., Manfred
;
Heikenwälder, Mathias
)
Major Research Instrumentation
Completed projects
High dimensional in situ proteomics imaging system
International Research Training Groups
Completed projects
GRK 1302: The PI3K Pathway in Tumour Growth and Diabetes
(Spokesperson
Nürnberg, Bernd
)
Clusters of Excellence (ExStra)
Current projects
EXC 2124: Controlling Microbes to Fight Infections (CMFI)
(Spokespersons
Brötz-Oesterhelt, Heike
;
Ley, Ruth E.
;
Peschel, Andreas
)
EXC 2180: Image-Guided and Functionally Instructed Tumor Therapies (iFIT)
(Spokespersons
Pichler, Bernd
;
Rammensee, Hans-Georg
;
Walz, Juliane
;
Zender, Lars
)
NFDI technical and methodological consortia
Current projects
GHGA – German Human Genome-Phenome Archive
(Spokesperson
Stegle, Ph.D., Oliver
)
