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Institution
Universitätsklinikum Essen
Institut für Experimentelle Immunologie und Bildgebung
Address
Universitätsstraße 2
45141 Essen
Deutschland
GERiT
This institution in GERiT
45141 Essen
Projects
Priority Programmes
Completed projects
Heparan sulfate in Degenerating Joint Diseases
(Applicant
Vortkamp, Andrea
)
Interplay between the Immune System and the Bone in the SWAP-70-/-mouse
(Applicant
Garbe, Annette
)
Intravital imaging of the interaction of the pathogenic fungus Aspergillus fumigatus with cells of the innate and adaptive immune system
(Applicant
Gunzer, Matthias
)
Investigation of the role of the nuclear receptor NR4a1 during bone turnover and maintenance of the hematopoietic niche in the bone marrow
(Applicant
Krönke, Gerhard
)
Relevance of osteal macrophages in bone remodeling
(Applicants
Amling, Michael
;
Schinke, Ph.D., Thorsten
)
The role of CXCR2-ligands for neutrophil mobilization from the bone marrow to peripheral sites
(Applicants
Gunzer, Matthias
;
Waisman, Ari
)
Research Grants
Current projects
Crosstalk between Thrombospondin-1 and proliferation of bladder epithelial cells in urinary tract infection during chronic lymphocytic leukemia
(Applicant
Engel, Daniel Robert
)
How the interaction with gut microbiota shapes the impact of neutrophils on ischemic brain injury
(Applicant
Singh, Ph.D., Vikramjeet
)
Impact of macrophages on neutrophils and endothelial cells in the kidney in hemolytic uremic syndrome induced by shiga toxin-producing E-coli
(Applicant
Engel, Daniel Robert
)
Multimodal preclinical imaging of Aspergillus fumigatus invasion and treatment
(Applicants
Bézière, Nicolas
;
Gunzer, Matthias
)
Completed projects
Ontogenese und Migrationsverhalten pathogenetisch relevanter dendritischer Zellen und T Zellen im postoperativen Ileus
(Applicant
Engel, Daniel Robert
)
Regulation of neutrophil migration by tissue macrophages
(Applicant
Engel, Daniel Robert
)
Role of neutrophil granulocytes after stroke: mechanisms of brain entry, neutrophil-induced disturbed brain recovery and remodeling
(Applicants
Gunzer, Matthias
;
Hermann, Dirk M.
)
Rolle der alveolaren Typ II Epithelzellen und des Toll-like Rezeptor 7 für die erhöhte Suszeptibilität gegenüber bakterieller Superinfektion bei Influenzapneumonie
(Applicants
Bruder, Dunja
;
Gunzer, Matthias
)
Suppression of the innate anti-bacterial response in Chronic Lymphocytic Leukemia
(Applicants
Engel, Daniel Robert
;
Sitek, Barbara
)
Virus-induced regulatory T cells in retroviral infection: new targets for immunotherapy of chronic infectious diseases.
(Applicants
Dittmer, Ulf
;
Gunzer, Matthias
)
Research Units
Current projects
FOR 2879: ImmunoStroke: From immune cells to stroke recovery
(Spokesperson
Liesz, Arthur
)
FOR 5427: BActerial Renal InfeCtion And DEfense (BARICADE)
(Spokesperson
Wagenlehner, Florian
)
ImmunoStroke: Microglial responses controlling post-stroke angiogenesis and microvascular integrity
(Applicants
Gunzer, Matthias
;
Hermann, Dirk M.
;
Ludewig, Peter
)
Regulierung der Immunsuppression durch CD163 bei Pyelonephritis und chronischer lymphatischer Leukämie
(Applicant
Engel, Daniel Robert
)
Completed projects
Die Rolle des Endocannabinoidsystems bei der Steuerung der Migration und neuronalen Kontaktaufnahme von Mikroglia bei ischämischer Gewebeschädiung im ZNS
(Applicants
Gunzer, Matthias
;
Ullrich, Oliver
)
Collaborative Research Centres
Completed projects
Die Rolle von neutrophilen Granulozyten und Mikroglia bei ischämischer Gewebeschädigung im ZNS
(Project Heads
Gunzer, Matthias
;
Reymann, Klaus
)
Molekulare Mechanismen der differentiellen Aktivierung naiver T-Zellen durch schwache und starke Antigen-präsentierenden Zellen
(Project Head
Gunzer, Matthias
)
Major Research Instrumentation
Completed projects
2-Photonenmikroskop
Feldemissions-Rasterelektronenmikroskop
Hochgeschwindigkeits-Zellsortiersystem
Mass spectrometer with MALDI2 and ESI ion source, Laser Capture Microdissection device
Spektral-Konfokalmikroskop mit Weißlichtlaser, FLIM und Hochauflösung
TIRF Mikroskop mit FRAP und Hochauflösung
Transmissionselektronenmikroskop
Major Instrumentation Initiatives
Current projects
A deconvolution Light-Sheet Microscope for Mesoscopic Tissue Imaging
Clinical Research Units
Current projects
KFO 337: Phenotypic Therapy and Immune Escape in Cancer (PhenoTImE): pre-clinical and translational advance of the CRU 337
(Spokesperson
Schadendorf, Dirk
)
Unraveling the plasticity and tumor-promoting role of neutrophils as a function of tumor heterogeneity
(Applicants
Gunzer, Matthias
;
Helfrich, Ph.D., Iris
)
CRC/Transregios
Current projects
Identification of a molecular signature that influences neutrophil migration and function in urinary tract infection during chronic lymphocytic leukaemia
(Project Head
Engel, Daniel Robert
)
Impact of type I interferons on tumour-dependent granulopoiesis and neutrophil tumourigenicity
(Project Heads
Hasenberg, Anja
;
Jablonska-Koch, Jadwiga
)
The role of Ly6g and CD177 as “eat me” signals to control neutrophil-mediated tissue destruction in stroke
(Project Heads
Gunzer, Matthias
;
Hermann, Dirk M.
)
TH transporters in myelin formation and regeneration
(Project Heads
Engel, Daniel Robert
;
Heuer, Heike
)
Visual data analysis platform for predesigned workflows - Research data management (INF)
(Project Heads
Engel, Daniel Robert
;
Führer-Sakel, Dagmar
;
Köster, Johannes
;
Mittag, Jens
;
Opitz, Robert
;
Rehwald, Stephanie
)
Visualizing neutrophils in context
(Project Heads
Dreisewerd, Klaus
;
Engel, Daniel Robert
;
Söhnlein, Oliver
)
Completed projects
Interplay between bacterial pyelonephritis and renal fibrosis
(Project Head
Engel, Daniel Robert
)
Virus-induzierte regulatorische T Zellen in retroviralen Infektionen: Neue Ziele für die Immuntherapie von chronischen Infektionen
(Project Heads
Bayer, Wibke
;
Dittmer, Ulf
;
Gunzer, Matthias
;
Zelinskyy, Gennadiy
)
Additional Information
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