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Institution
Universitätsklinikum Hamburg-Eppendorf
Zentrum für experimentelle Medizin
Institut für Experimentelle Pharmakologie und Toxikologie
Address
Martinistraße 52
20251 Hamburg
Deutschland
GERiT
This institution in GERiT
20251 Hamburg
Projects
Research Grants
Current projects
Circulating metabolites in atrial biology and disease
(Applicants
Stenzig, Justus
;
Zeller, Ph.D., Tanja
)
Contribution of SERCA2, RyR2, NCX1 and PMCA to excitation-contraction coupling in human cardiomyocytes – tackling an old question with modern technologies
(Applicants
Christ, Torsten
;
Eschenhagen, Thomas
)
Effects of the atrial fibrillation risk region on chromosome 4q25 and PITX2 on atrial metabolic and mitochondrial function
(Applicants
Cuello, Friederike
;
Kirchhof, Paulus
)
How cardiac fibroblasts react to cardiomyocyte signaling – focus on epigenetic signal integration
(Applicant
Stenzig, Justus
)
Impact of genes in the PITX2 locus on the electrophysiology of human atrial induced pluripotent stem cell-derived cardiomyocytes
(Applicants
Christ, Torsten
;
Eschenhagen, Thomas
;
Stoll, Monika
)
Non-invasive Monitoring of Hypertrophic Cardiomyopathy using Cardiac Magnetic Resonance Virtual Biopsy (cardiacMRBIOPSY)
(Applicants
Carrier, Lucie
;
Ku, Ph.D., Min-Chi
;
Waiczies, Sonia
)
Protein arginine methylation - a posttranslational collagen modification relevant for crosslinking and degradation of collagen in aortic aneurysms?
(Applicant
Hannemann, Juliane
)
Transplantation of stem cell-derived cardiomyocytes with a chemogenetic off-on switch to improve cell engraftment and inhibit engraftment induced arrhythmias
(Applicant
Weinberger, Florian
)
Unraveling the molecular pathomechanisms in PRKG1 variant-associated aortopathies
(Applicants
Cuello, Friederike
;
Demal, Till Joscha
;
Herberg, Friedrich-Wilhelm
)
Completed projects
ADMA als kardiovaskulärer Risikofaktor in der Framingham Offspring-Population
(Applicant
Böger, Rainer
)
Analysis of G protein-coupled receptors on human embryonic stem cells
(Applicant
Hansen, Arne
)
Bedeutung von Polymorphismen in Genen für CYP2D6 und Elementen der beta-adrenergen Signaltransduktion für die klinische Antwort auf die Betablocker Bisoprolol und Carvedilol
(Applicant
Eschenhagen, Thomas
)
Biosynthese und Metabolismus sowie funktionelle Bedeutung des endogenen NO-Synthase-Inhibitors "Asymmetrisches Dimethylarginin" (ADMA)
(Applicant
Böger, Rainer
)
Development of a set up for the combined measurement of force, myocyte tension and mitochondrial redox status in rat engineered heart tissue to characterize cardiac hypertro
(Applicant
Rhoden, Alexandra
)
Entwicklung substanz- und wirkungsspezifischer bakterieller Testverfahren zur Detektion mutagener Effekte von komplexen Umweltgemischen
(Applicant
Vahl, Hans Heinrich
)
Generierung unc Charakterisierung von DDAH1 und DDAH2 Knockout Mäusen zur Untersuchung der pathophysiologischen Bedeutung des endogenen NOS-Inhibitors ADMA
(Applicant
Maas, Renke
)
Genotoxicity and metabolism of isomeric bis(dichloropropyl)ether
(Applicant
Neurath, Götz
)
Identification of epigenetic mechanisms of transcriptional regulation in cardiac hypertrophy using Engineered Heart Tissue
(Applicant
Stenzig, Justus
)
Impact of active force development from transplanted engineered heart tissue on left ventricular function
(Applicant
Weinberger, Florian
)
Investigating ventricular arrhythmia development in hypertrophic cardiomyopathy in a mouse model and patient samples
(Applicant
Flenner, Frederik
)
Kontraktionskraftmessung an embryonalen Kardiomyozyten in einer Kollagengelmatrix
(Applicant
Eschenhagen, Thomas
)
Modeling heart disease with iPS-derived engineered heart tissue, part II
(Applicant
Hansen, Arne
)
Modeling inherited cardiac diseases with iPS-derived engineered heart tissue
(Applicant
Eschenhagen, Thomas
)
Rolle von beta-Catenin im Rahmen des myokardialen Remodeling bei linksventrikulärer Druckbelastung und nach Myokardinfarkt
(Applicant
Eschenhagen, Thomas
)
S-glutathiolation of cardiac myosin-binding protein C in contractile dysfunction
(Applicant
Cuello, Friederike
)
Studies on the role of MAP kinases in the regulation of egr-1 and c-fos expressions in erythroleukemia cells by Ca2plus-signals and Erythropoietin
(Applicant
Schaefer, Andras
)
Thiol-disulfide modification regulates p90 ribosomal S6 kinase activity in the heart
(Applicant
Cuello, Friederike
)
Research Fellowships
Completed projects
Assessment of the differentiation potential of Sca-1-positive cells in the heart
(Applicant
Weinberger, Florian
)
A study to assess the drug interaction between metoprolol and the cox-2 inhibitor Celecoxib or Rofecoxib in healthy volunteers
(Applicant
Werner, Ulrike
)
Aufklärung von Mechanismen der neuronalen Transdifferenzierung hämatopoetischer Stammzellen
(Applicant
Hansen, Arne
)
Research Units
Completed projects
Animal experimentation and cardiac phenotyping of transgenic mouse models
(Applicant
Eschenhagen, Thomas
)
Effects and regulation of phosphatase inhibitor-1 in the heart and its therapeutic potential in heart failure
(Applicant
El-Armouche, Ali
)
FOR 604: Signalling Pathways in the Healthy and Diseased Heart
(Spokesperson
Eschenhagen, Thomas
)
Investigation of the ubiquitin-proteasome system in the pathogenesis of familial hypertrophic cardiomyopathy
(Applicant
Carrier, Lucie
)
Clinical Research Units
Current projects
Generation of human induced pluripotent stem cells
(Applicant
Hansen, Arne
)
KFO 5029: Precision Medicine for Early-Onset Low Bone Mineral Density Disorders
(Spokesperson
Amling, Michael
)
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