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Institution
Johannes Gutenberg-Universität Mainz
Universitätsmedizin
III. Medizinische Klinik und Poliklinik
Address
Langenbeckstraße 1
55131 Mainz
Deutschland
GERiT
This institution in GERiT
55131 Mainz
Projects
Research Grants
Current projects
Machine learning-based prediction of the first-line AML treatment response
(Applicant
More, Ph.D., Piyush
)
Modifying macrophage polarization to improve cancer immunotherapies
(Applicants
Alflen, Astrid
;
Bohn, Toszka
)
Completed projects
Analyses of murine neutrophil granulocyte steady-state homeostatic regulation
(Applicant
Bugl, Stefanie
)
Charakterisierung der antimikrobiellen und antiinflammatorischen Funktion der humanen Granulozyten-Arginase
(Applicant
Munder, Markus
)
Identifizierung pathogenetisch relevanter Sekundäraberrationen bei der Core Binding Factor Akuten Myeloischen Leukämie mit Hilfe array-basierter SNP-Analysen
(Applicant
Döhner, Konstanze
)
Regulation und Funktion des Arginintransportes in humanen T-Lymphozyten
(Applicants
Closs, Ph.D., Ellen Ildicho
;
Munder, Markus
)
Spezielle Differenzierung organständiger humaner T-Lymphozyten der Lunge hinsichtlich des Ansprechens über den T-Zell-Rezeptorkomplex (DC3) und kostimulatorischer Signale (CD2) sowie der Resistenz gegenüber Xenobiotika im Vergleich zum peripheren Blut
(Applicant
Becker, Kai
)
The impact of AML - stromal cell interaction on malignant transformation, maintenance of leukemic stem cells and drug resistance
(Applicant
Kindler, Thomas
)
The role of TREM-1 and it´s ligand in regulating the innate immune response
(Applicant
Radsak, Markus P.
)
Validation of the questionnaire "Care of the Dying Evaluation (CODE)" for relatives of deceased patients in Germany
(Applicants
Ostgathe, Christoph
;
Weber, Martin
)
Clinical Research Units
Completed projects
Cytomegalievirus (CMV)-spezifische CD4+ und CD8+ T-Zellen durch T-Zell-Rezeptor RNA Transfer
(Applicant
Thomas, Simone
)
Evaluation von T-Zell-vermittelter Graft-versus-Host- und Graft-versus-Leukämiereaktivität in einem chimären human-murinen NOD/SCID/yc null-Transplantationsmodell
(Applicant
Hartwig, Ph.D., Udo Frank
)
Generierung von leukämiereaktiven Spender-T-Zellen für die adoptive Immuntherapie
(Applicant
Distler, Eva
)
Identifizierung von Zielantigenen alloreaktiver zytotoxischer T-Zellen mittels cDNA-Expressionsklonierung
(Applicant
Wölfel, Catherine
)
KFO 183: Optimised Allogeneic Lymphocyte Therapy
(Spokesperson
Theobald, Matthias
)
Modulation von Graft-versus-Host und Graft-versus-Tumor Reaktionen durch regulatorische T-Zellen
(Applicant
Radsak, Markus P.
)
Molekulare T-Zelltherapie in der allogenen hämatopoetischen Stammzelltransplantation
(Applicant
Echchannaoui, Hakim
)
Molekulare T-Zelltherapie in der allogenen hämatopoetischen Stammzelltransplantation
(Applicant
Voss, Ralf-Holger
)
Independent Junior Research Groups
Current projects
Rational p300/CREBBP KAT inhibition in AML
(Applicant
Sasca, Daniel
)
Completed projects
Epigenetic control of leukemic gene expression by menin and wildtype MLL1 complex members.
(Applicant
Kühn, Michael
)
Collaborative Research Centres
Current projects
Molecular T cell immunotherapy and inhibition of tumor immune escape mechanisms
(Project Heads
Munder, Markus
;
Theobald, Matthias
)
Targeting chromatin complexes to reverse AML immune escape for engineered cell therapy
(Project Heads
Fulda, Simone
;
Kühn, Michael
;
Ullrich, Evelyn
)
Tumor-specific immunization by transcutaneous vaccination: Preclinical and clinical development of drug forms for adjuvant therapy of Merkel cell carcinoma
(Project Heads
Grabbe, Stephan
;
Langguth, Peter
;
Radsak, Markus P.
)
Type-I Interferons – a double-edged sword in Myeloproliferative Neoplasms and Chronic Viral Infections
(Project Heads
Muth, Sabine
;
Radsak, Markus P.
)
Completed projects
Identifizierung von T-zellerkannten Antigenen auf menschlichen Tumoren
(Project Head
Wölfel, Thomas Johann
)
IL-4 und IL-13-Signaltransduktion bei akuter lymphatischer Leukämie
(Project Head
Aman, Mohamad Javad
)
Patienten- und Forschungsmaterial, Infrastruktur
(Project Head
Derigs, Hans Günter
)
Peptidsynthese und Proteinanalytik
(Project Head
Theobald, Matthias
)
Selektion und Transfer therapeutischer T-Zellrezeptoren
(Project Heads
Schild, Hansjörg
;
Theobald, Matthias
;
Voss, Ralf-Holger
)
Therapiestudien
(Project Head
Theobald, Matthias
)
Transfection of tumor-reactive T cells using RNA loaded nanocapsules
(Project Heads
Mailänder, Volker
;
Wölfel, Thomas Johann
)
Tumorabstoßung durch zytotoxische T-Zellen in vivo: Einfluß von Toll-like Rezeptor vermittelten Signalen
(Project Heads
Radsak, Markus P.
;
Schild, Hansjörg
)
Research Fellowships
Completed projects
Charakterisierung der biologischen Aktivität von neuen, multivalenten, "small molecule" Kinase-Inhibitoren
(Applicant
Kindler, Thomas
)
Epigenetic, Genomic, and Functional Characterization of MLL-AF9 Rearranged Acute Myeloid Leukemia
(Applicant
Kühn, Michael
)
Modulation of T cell exhaustion to enhance anti-cancer immune responses
(Applicant
Alflen, Astrid
)
Priority Programmes
Completed projects
Activation mechanisms by TREM-1 and it´s significance in immunomodulation post trauma
(Applicant
Radsak, Markus P.
)
Interactions between mast cells and neutrophils in murine models of acute inflammation
(Applicant
Stassen, Michael
)
CRC/Transregios
Completed projects
Clinical Development of imiquimod based immunotherapy
(Project Head
Radsak, Markus P.
)
Transcutaneous immunization: Mechanisms of intercellular crosstalk in the skin
(Project Heads
Radsak, Markus P.
;
Stassen, Michael
)
WBP Fellowship
Current projects
Optimizing T-cell functional avidity
(Applicant
Kropp, Korbinian
)
Research Training Groups
Completed projects
GRK 1043: Antigen-specific Immuntherapy
(Spokesperson
Wölfel, Thomas Johann
)
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