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Institution
Universitätsklinikum Erlangen AöR
Medizinische Klinik 5 - Hämatologie und Internistische Onkologie
Address
Ulmenweg 18
91054 Erlangen
Deutschland
GERiT
This institution in GERiT
91054 Erlangen
Projects
Research Grants
Current projects
Characterization of the Notch/PKCβ/NF-κB signalling pathway in the tumor microenvironment of chronic lymphocytic leukemia
(Applicant
Lutzny-Geier, Gloria
)
Modelling of viral respiratory co-infection dynamics in human epithelium
(Applicants
Graw, Frederik
;
Rodriguez Burgos, Ph.D., Rosa Estefania
)
Re-education of immunosuppressive myeloid cells to increase the efficacy of chimeric antigen receptor (CAR) T cells.
(Applicants
Bruns, Heiko
;
Mougiakakos, Dimitrios
)
Completed projects
Allogene Stammzelltransplantation zur Therapie hochmaligner Non-Hodgkin-Lymphome: Entwicklung eines murinen Modells am Beispiel des spontan entstehenden c-myc induzierten Lymphoms der Maus
(Applicant
Gerbitz, Armin
)
Analysis of gene expression in macrophages
(Applicant
Krause, Stefan
)
Antibody-targeted duotoxins combining Pseudomonas exotoxin and mertansine (DM1) for the treatment of B-cell malignancies
(Applicant
Müller, Fabian
)
Antigenspezifische Elimination von primären humanen CD4+ und CD8+ T-Zellen durch Apoptose-induzierte artifizielle antigenpräsentierende Zellen in vitro
(Applicant
Fleck, Martin
)
Identification of molecular mechanisms of cholestatic pruritus
(Applicant
Kremer, Ph.D., Andreas Emanuel
)
Immune-regulatory function of human CD3 CD4-/CD8- double negative T cells
(Applicant
Mackensen, Andreas
)
Importance of aberrant double negative T-cells in patients with autoimmune lymphoproliferative syndrome (ALPS)
(Applicants
Mackensen, Andreas
;
Völkl, Simon
)
Induktion von spezifischer T-Zell Toleranz durch Apoptose-induzierende antigenpräsentierende Zellen mittels adenoviralem Gentransfer
(Applicant
Fleck, Martin
)
Modulation der Differenzierung und Aktivierung dendritischer Zellen durch das Tumormilieu - Untersuchungen in einem dreidimensionalen Tumorsphäroid Kokultur Modell
(Applicant
Kreutz, Marina P.
)
Schäden und proliferative Vorgänge am Endothel nach allogener Knochenmarktransplantation in murinen Transplantationsmodellen
(Applicant
Gerbitz, Armin
)
The role of intracellular antigen processing for the induction of a selective graft-versus-leukemia effect without graft versus host disease
(Applicant
Kremer, Anita
)
Transdifferentiation of malignant B-cells
(Applicant
Bruns, Heiko
)
Clinical Research Units
Completed projects
Immunregulatorische Funktionen humaner TCRáâ+ CD4-CD8- doppelt negativer T-Zellen
(Applicant
Mackensen, Andreas
)
Suppression of human T cells by 5'-methylthioadenosine
(Applicants
Aigner, Michael
;
Mackensen, Andreas
)
Collaborative Research Centres
Completed projects
Adoptive transfer of CMV/EBV multi-epitope specific T-cells for prevention and treatment of virus reactivation in patients after matched allogeneic stem cell transplantation
(Project Heads
Aigner, Michael
;
Gerbitz, Armin
;
Mackensen, Andreas
)
Adoptive Transfer of cytomegalovirus-specific memory B-cells: Implementation of a Phase I/IIa clinical study
(Project Heads
Mach, Michael
;
Winkler, Thomas
;
Winkler, Julia
)
Immunoregulatory Function of Human TCRαβ+ CD4-/CD8- Double Negative T cells and its Potential Role in Limiting Auto- and Alloreactive Immune Responses
(Project Head
Mackensen, Andreas
)
Immuntherapie beim malignen Melanom mit tumorpeptidbeladenen, autologen dendritischen Zellen
(Project Head
Mackensen, Andreas
)
Tumor-Immuntherapie durch Vakzinierung mit tumorantigen-beladenen dendritischen Zellen und adoptiven T-Zell-Transfer
(Project Heads
Behringer, Dirk
;
Mackensen, Andreas
)
Research Fellowships
Completed projects
Antigen processing and presentation of HLA class II restricted minor histocompatibility antigens
(Applicant
Kremer, Anita
)
Die Rolle des Tim-3 im angeborenen Immunsystem und Effekte des Tim-1 auf die Funktion von Th1-, Th-17- und CD8+ T-Zellen
(Applicant
Spörl, Silvia
)
Identification of the molecular mechanism that leads to a resistance against pseudomonas exotoxin A based immunotoxins
(Applicant
Müller, Fabian
)
CRC/Transregios
Current projects
Aldehyde dehydrogenase 3A2 (ALDH3A2) as a novel regulator of inflammation and fibrotic tissue remodeling in sclerodermatous chronic graft-versus-host disease
(Project Heads
Distler, Jörg Hans Wilhelm
;
Jitschin, Ph.D., Regina
;
Spriewald, Bernd
)
Deciphering the role of HLA-DO in immune responses after allogeneic stem cell transplantation
(Project Heads
Kremer, Anita
;
Reimann, Hannah
)
Dysregulation of the B-lymphocyte compartment leading to chronic GvHD
(Project Heads
Winkler, Thomas
;
Winkler, Julia
;
Wolff, Daniel
)
Integrated Research Training Group of the CRC/TRR 221
(Project Heads
Berberich-Siebelt, Friederike
;
Edinger, Matthias
;
Kremer, Anita
;
Walles, Heike
)
Metabolic stress related immune alterations with impact on graft-versus-leukemia effect in allogeneic stem cell transplantation
(Project Heads
Mackensen, Andreas
;
Mougiakakos, Dimitrios
)
Regulation of the immune balance during allogeneic hematopoietic stem cell transplantation (HSCT) by vitamin D3
(Project Heads
Bruns, Heiko
;
Kreutz, Marina P.
;
Peter, Katrin
)
Therapeutic targeting of T-follicular cells in GvHD
(Project Heads
Berberich-Siebelt, Friederike
;
Spörl, Silvia
)
Completed projects
Drug-induced Apoptosis and Senescence: Interaction with the adaptive Immune System in c-myc induced murine B Cell Lymphomas
(Project Heads
Bornkamm, Georg Wilhelm
;
Gerbitz, Armin
;
Schmitt, Clemens A.
)
Metabolic modification of mesenchymal stromal cells for harnessing their immunoregulatory capacity in graft-versus-host disease
(Project Head
Jitschin, Ph.D., Regina
)
The human c-MYC-gene-product as target antigen in a murine model of high grade B cell lymphoma
(Project Heads
Bornkamm, Georg Wilhelm
;
Gerbitz, Armin
;
Mautner, Josef
)
Research Training Groups
Current projects
GRK 2740: Immunomicrotope: Microenvironmental, Metabolic and Microbial Signals Regulating Immune Cell-Pathogen Interactions
(Spokesperson
Bogdan, Christian
)
Completed projects
GRK 1660: Key Signals of Adaptive Immune Response
(Spokesperson
Jäck, Hans-Martin
)
Additional Information
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