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Institution

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Freie Universität Berlin
Institut für Chemie und Biochemie
Arbeitsgruppe Proteinbiochemie

Address Thielallee 63
14195 Berlin
Deutschland

GERiT This institution in GERiT

14195 Berlin

Projects

Research Grants
- Current projects
  - Mechanism and in vitro reconstitution of tapasin-mediated peptide exchange
    (Applicant Freund, Christian )
- Completed projects
  - Dynamic properties of MHC class II allotypes
    (Applicant Freund, Christian )
  - GYF-Domänen-vermittelte Protein-Wechselwirkungen
    (Applicant Freund, Christian )
  - Mechanismus des durch HLA-DM und kleine Moleküle vermittelten MHCII:Peptid-Austausch
    (Applicants Freund, Christian ; Kühne, Ronald )
  - Regulatorische Tyrosin-Phosphorylierungen von Vav und ADAP bei der T-Zell-Rezeptor-vermittelten Integrinadhäsion
    (Applicant Freund, Christian )
  - Struktur-Funktionsanalyse der GYF-Domäne
    (Applicant Freund, Christian )
Research Units
- Completed projects
  - Administration and central services
    (Applicant Oschkinat, Hartmut )
  - FOR 806: Interfering with Intracellular Protein-protein Interactions - Probing Protein Functions with Small Molecules
    (Spokespersons Freund, Christian ; Oschkinat, Hartmut )
  - GYF domain mediated protein: protein interactions
    (Applicant Freund, Christian )
Priority Programmes
- Completed projects
  - Establishing strategies for sortase-catalyzed multi-peptide assemblies to profile T-cell selectivity
    (Applicants Freund, Christian ; Schwarzer, Dirk )
Major Research Instrumentation
- Completed projects
Collaborative Research Centres
- Completed projects
  - ADAPtive T cell migration into the stressed brain
    (Project Heads Freund, Christian ; Kliche, Stefanie ; Schraven, Burkhart ; Stork, Oliver )
  - Core service facilities for the SFB 765: NMR spectroscopy, surface plasmon resonance, quartz crystal microbalance, calorimetry, and mass spectrometry
    (Project Heads Dernedde, Jens ; Freund, Christian ; Haag, Rainer ; Risse, Thomas ; Schalley, Christoph A. )
  - Multivalent interactions of WW and SH2 domains containing proteins
    (Project Heads Freund, Christian ; Oschkinat, Hartmut )
  - Proteomics platform for protein interaction mapping
    (Project Heads Freund, Christian ; Liu, Fan ; Multhaup, Gerhard ; Weise, Christoph )
  - Regulation of SH3 domain-based scaffolds in clathrin-mediated endocytosis
    (Project Heads Freund, Christian ; Haucke, Ph.D., Volker )
  - Regulatory phosphorylation of scaffolding proteins of the inside-out-signaling complex
    (Project Heads Freund, Christian ; Höfer, Thomas )
CRC/Transregios
- Current projects
  - Central Coordination
    (Project Heads Freund, Christian ; Nickel, Walter )
  - Switching antigens by the exchange catalyst HLA-DM
    (Project Heads Freund, Christian ; Höfer, Thomas )
  - The palmitoylation switch in activated T cells
    (Project Heads Brügger, Britta ; Freund, Christian )
  - TRR 186: Molecular Switches: Spatio-temporal Control of Cellular Signal Transmission
    (Spokespersons Freund, Christian ; Nickel, Walter )
- Completed projects
  - Systematic characterization of phosphoinositide switches involved in T cell function
    (Project Heads Freund, Christian ; Gavin, Anne-Claude ; Russell, Robert B. )

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