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Institution

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Universität Leipzig
Medizinische Fakultät
Institut für Wirkstoffentwicklung

Address Brüderstraße 34
04103 Leipzig
Deutschland

GERiT This institution in GERiT

04103 Leipzig

Projects

Research Fellowships
- Completed projects
  - De novo structure prediction of helical transmembrane proteins using RosettaTMH and pseudocontact shift NMR data
    (Applicant Künze, Georg )
Emmy Noether International Fellowships
- Completed projects
  - Beschleunigung und Automatisierung der Strukturbestimmung von Proteinen auf Basis von experimentellen NMR-Parametern durch den Einsatz neuronaler Netze und genetischer Algorithmen
    (Applicant Meiler, Jens )
Collaborative Research Centres
- Current projects
  - Allosteric regulation of PAR1 biased signaling by tethered peptide ligands and receptor oligomerization
    (Project Heads Isermann, Berend ; Künze, Georg )
  - Data management and computational models of structure and dynamics, and evolution of GPCRs
    (Project Heads Hildebrand, Peter ; Meiler, Jens ; Stadler, Peter Florian )
  - Development of modulators at the chemokine-like receptor to elucidate its role in obesity
    (Project Heads Beck-Sickinger, Annette G. ; Meiler, Jens )
  - Identification of molecular mechanisms and druggable targets for the treatment of obesity
    (Project Heads Meiler, Jens ; Sträter, Norbert )
  - Innovative artificial intelligence algorithms for modeling and docking of GPCRs
    (Project Head Meiler, Jens )
  - Investigation of the structure and dynamics of the ghrelin/GHS receptor complex
    (Project Heads Hildebrand, Peter ; Huster, Daniel ; Schoeder, Clara )
  - Modelling, understanding, and predicting >2 million Arabidopsis proteoforms in the post-genomic era
    (Project Heads Kastritis, Panagiotis L. ; Künze, Georg )
  - Mutation-Sensitive Prediction of Transcription Factor-DNA Interactions in Plants
    (Project Heads Große, Ivo ; Meiler, Jens )
  - Targeting of function and structure of Arabidopsis dicing complex proteoforms on microRNA biogenesis
    (Project Heads Laubinger, Sascha ; Schoeder, Clara )
Research Grants
- Completed projects
  - Ensemble Docking Interrogates Structural Determinants of Ligand-Protein Interactions
    (Applicants Beck-Sickinger, Annette G. ; Schöneberg, Torsten )
Priority Programmes
- Current projects
  - Virtual Drug Screening in the Chemical Space Accessible by Chemical Synthesis
    (Applicants Meiler, Jens ; Stadler, Peter Florian )
CRC/Transregios
- Current projects
  - Distances by site-specific DNP for biomolecular structure determination
    (Project Heads Corzilius, Björn ; Künze, Georg ; Wiegand, Thomas )
  - Flavomaquettes with observer spin label for hyperpo-larized EPR
    (Project Heads Coin, Irene ; Elgeti, Matthias ; Meiler, Jens )
  - Information Infrastructure Project: Non-invasive interdisciplinary research data management in federated organizational environments
    (Project Heads Gaedke, Martin ; Meiler, Jens )
  - Scientific service project: Tailored chemical and biochemical probe factory (Peptide Factory)
    (Project Heads Coin, Irene ; Lamers, Christina )
  - Systematically designed polypeptides to explore the CISS effect
    (Project Heads Gemming, Sibylle ; Künze, Georg )

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