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Institution
Rheinische Friedrich-Wilhelms-Universität Bonn
Medizinische Fakultät
Institut für Medizinische Mikrobiologie,
Immunologie und Parasitologie
Address
Venusberg-Campus 1
53127 Bonn
Deutschland
GERiT
This institution in GERiT
53127 Bonn
Projects
Research Grants
Current projects
Eosinophil and neutrophil ETosis during human filarial infection
(Applicant
Hübner, Marc
)
Mansonella perstans in vitro culture system and RAG2IL-2Rgamma-deficient C57BL/6 mouse model of filariasis: Novel approaches to elucidate Mansonella perstans biology and potential treatment strategies
(Applicant
Ritter, Manuel
)
Native medicinal plants from Togo: defining anti-inflammatory and anti-helminthic properties of bioactive components
(Applicant
Ritter, Manuel
)
Role of IL-9 signaling in the pathogenesis of obesity and aging and in helminth-mediated immunomodulation in type 2 diabetes
(Applicant
Karunakaran, Ph.D., Indulekha
)
Completed projects
Analyse von synergistischen Mechanismen zwischen Th1- und Th2-Antworten und von antgonistischen Wirkungen innerhalb der Th2-Antwort bei der experimentellen Filarieninfektion von Mäusen (Litomosoides sigmodontis)
(Applicant
Hoerauf, Achim
)
Analysis of cell wall architecture and metabolism of a vancomycin resistant Staphylococcus aureus strain
(Applicant
Bierbaum, Gabriele
)
Charakterisierung des Zellwandbiosynthesekomplexes und der Vancomycinresistenz in Staphylokokken
(Applicant
Bierbaum, Gabriele
)
Crosstalk of macrophages and eosinophils in helminth-mediated protection during experimental sepsis
(Applicant
Hübner, Marc
)
Defining immunosuppressive profiles of MDSCs in chronic helminth infections
(Applicant
Layland-Heni, Laura Elizabeth
)
Depletion von Wolbachien, Endobakterien in Filarien, durch Tetrazyklin: Analyse der molekularen Basis der Interaktion zwischen Endobakterien und Filarien
(Applicant
Hoerauf, Achim
)
Determination of molecular mechanisms supporting the anti-inflammatory properties of IgG4 antibodies in filarial infected individuals
(Applicant
Hoerauf, Achim
)
Dissecting the effects of filarial-associated immunomodulation on HIV susceptibility
(Applicants
Hoerauf, Achim
;
Kroidl, Inge
)
First-Stage Genome Wide Association Study (GWAS) of Lymphatic Filariasis Pathology
(Applicant
Pfarr, Ph.D., Kenneth
)
Genetics of Lymphedema and Hydrocele in Filariasis
(Applicant
Pfarr, Ph.D., Kenneth
)
Genetics of Lymphedema and Hydrocele in Lymphatic Filariasis
(Applicant
Pfarr, Ph.D., Kenneth
)
How parasitic helminth infections alter immunity in the female reproductive tract and control of sexually transmitted infections.
(Applicant
Layland-Heni, Laura Elizabeth
)
Impact of human filarial infections on the metabolic and immunological profile
(Applicant
Hübner, Marc
)
Inhibition des eukaryotischen Initiationsfaktors eIF5-A aus Plasmodien und humanen Zellen - Mechanismen der Apoptose-Induktion und Zielstruktur für einen gemeinsamen Therapieansatz zur Behandlung der Malaria und der HIV-Infektion
(Applicants
Hauber, Joachim
;
Holzgrabe, Ulrike
;
Saeftel, Michael
)
Involvement of dendritic cell Toll-like receptors in the innate response to Litomosoides sigmodontis infection and deviation by their Wolbachia endobacteria
(Applicant
Hoerauf, Achim
)
Mansonella perstans effects on BCG vaccine-induced protection against childhood tuberculosis as well as tuberculosis disease severity and recovery in Ghana and Cameroon
(Applicants
Hoerauf, Achim
;
Jacobsen, Marc
)
Post-genomic, functional characterization of filarial genes regulated in response to the loss of their Wolbachia endosymbionts
(Applicant
Pfarr, Ph.D., Kenneth
)
Resistenzmechanismen gegen Antibiotika mit der Zielstruktur Lipid II
(Applicant
Bierbaum, Gabriele
)
Th17-Treg Antagonism: Impact on Disease Outcome in Helminth Infections
(Applicant
Hoerauf, Achim
)
The effects of Mansonella perstans infections on concomitant mycobacterial infections and BCG vaccination efficacy in Ghana, Cameroon, and Benin
(Applicants
Hoerauf, Achim
;
Jacobsen, Marc
)
The mechanisms of evolution of antibiotic resistance in Staphylococcus aureus
(Applicant
Bierbaum, Gabriele
)
Wechselseitige Beeinflussung der Infektionsverläufe von muriner Malaria und Nematodeninfektion am Beispiel der Co-Infektion von Plasmodium berghei mit Litomosoides sigmodontis bzw. Nippostrongylus brasiliensis
(Applicant
Saeftel, Michael
)
Research Units
Current projects
Destruction, decay, and preservation: Early fossilization of leaf compressions
(Applicants
Bierbaum, Gabriele
;
Gee, Carole T.
)
Evolution and selection of resistant bacteria in the presence of subinhibitory concentrations of micropollutants
(Applicant
Bierbaum, Gabriele
)
FOR 2685: The Limits of the Fossil Record: Analytical and Experimental Approaches to Fossilization
(Spokesperson
Gee, Carole T.
)
FOR 5095: Pollutant – Antibiotic Resistance – Pathogen Interactions in a Changing Wastewater Irrigation System
(Spokesperson
Siemens, Jan
)
The role of microbes and biofilms in leaf fossilization
(Applicants
Bierbaum, Gabriele
;
Gee, Carole T.
)
Completed projects
Identification of new molecular targets and antibiotics as novel strategies against filaria infections: characterization of lipid II biosynthesis in Wolbachia endobacteria
(Applicant
Pfarr, Ph.D., Kenneth
)
Novel ribosomally synthesized peptide antibiotics from microbial genomes
(Applicant
Bierbaum, Gabriele
)
The impact of bacterial activity on decay and fossilization of arthropods: An experimental approach
(Applicants
Bierbaum, Gabriele
;
Rust, Jes
)
Collaborative Research Centres
Completed projects
Identification of helminth components which drive the generation of antigen-specific regulatory T cells and the influence of those cells in inducing protective IgG subclasses by B cells
(Project Heads
Hoerauf, Achim
;
Layland-Heni, Laura Elizabeth
)
Research Fellowships
Completed projects
Role of Toll-like receptors in dendritic cell maturation and T cell activation in response to Wolbachia and filarial antigens
(Applicant
Gentil, Katrin
)
CRC/Transregios
Completed projects
Mode of action of cell wall biosynthesis inhibitors in Wolbachia spp.
(Project Head
Pfarr, Ph.D., Kenneth
)
Clusters of Excellence (ExStra)
Current projects
EXC 2151: ImmunoSensation2 - the immune sensory system
(Spokespersons
Hartmann, Gunther
;
Kolanus, Waldemar
;
Latz, Eicke
;
Schultze, Joachim L.
)
Clusters of Excellence
Completed projects
EXC 1023: ImmunoSensation: The Immune Sensory System
(Spokesperson
Hartmann, Gunther
)
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