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Institution
Charité - Universitätsmedizin Berlin
Campus Benjamin Franklin
Medizinische Klinik mit Schwerpunkt Hämatologie,
Onkologie und Tumorimmunologie
Address
Hindenburgdamm 30
12203 Berlin
Deutschland
GERiT
This institution in GERiT
12203 Berlin
Projects
Research Grants
Current projects
Assessing clonal evolution in head and neck squamous cell carcinoma and its contribution to tumor progression and treatment resistance
(Applicants
Klinghammer, Konrad
;
Riecken, Kristoffer
;
Tinhofer-Keilholz, Ingeborg
)
Cell dynamics in disease and therapy
(Applicant
Dobbelstein, Matthias
)
Discovery of BCL-2-selective degraders for applications in hematological malignancies
(Applicants
Krönke, Jan
;
Steinebach, Christian
)
Dissecting and Modeling Evolution of Inter- and Intra-tumoral Heterogeneity in High-Risk Diffuse Large B-cell Lymphoma
(Applicants
Chapuy, Björn
;
Dietrich, Sascha
)
Dissecting and targeting SUMOylation to increase the efficacy of lymphoma immunotherapy
(Applicant
Keller, Ulrich
)
Identification of multiple myeloma initiating cells by integrated single-cell multi-omics-based lineage tracing
(Applicants
Haas, Ph.D., Simon
;
Krönke, Jan
;
Ludwig, Leif
)
SUMOylation in Lymphoma: Mechanisms and Therapeutic Targeting of the SENP6-RNF4 Axis
(Applicants
Keller, Ulrich
;
Müller, Stefan
)
Completed projects
Einsatz neuer Technologien für das Monitoring der lokalen und systemischen Immunantwort bei Immuntherapien von Tumorerkrankungen
(Applicant
Lee, Kang-Hun
)
Expressionsmuster von Tyrosinkinasen bei der akuten lymphatischen Leukämie des Erwachsenenalters.
(Applicant
Burmeister, Thomas
)
Molecular Characterization of Refractory and Relapsed DLBCL – Signatures of Response and Resistance to Salvage Therapy
(Applicant
Chapuy, Björn
)
Role of Cks1 for l-dependent and -indepentend cell cycle regulation, survival and quiescence in normal and leukemic hematopoiesis
(Applicant
Keller, Ulrich
)
T-Zell-Immunität beim Kolorektalkarzinom
(Applicant
Nagorsen, Dirk
)
Understanding mechanisms of drug resistance and clonal evolution in diffuse large B cell lymphoma
(Applicant
Reinhardt, Christian
)
Whole body image analysis for diagnosing patients with monoclonal plasma cell disorders
(Applicants
Menze, Björn
;
Weber, Marc-André
)
Research Fellowships
Completed projects
Functional screen of genes on chromosome 7q that contribute to the pathogenesis of myelodysplastic syndrome (MDS) / acute myeloid leukemia (AML) and to the response to hypomethylating agents
(Applicant
Krönke, Jan
)
Identifizierung und Charakterisierung von microRNA Signaturen von großzelligen Lymphomen
(Applicant
Chapuy, Björn
)
Rolle von c-Myc und N-Myc Onkoproteinen für die murine Hämatopoese und Vaskulogenese
(Applicant
Keller, Ulrich
)
T-cell receptor mimic antibodies in hematological and solid malignancies: Identification of novel targets and implications for combined immunochemotherapy
(Applicant
Klatt, Martin
)
Independent Junior Research Groups
Completed projects
Functional characterization of the CRBN E3 ubiquitin ligase, the target of lenalidomide
(Applicant
Krönke, Jan
)
Collaborative Research Centres
Current projects
Characterization of Richter-transformed lymphoma and genomic instability as a potential vulnerability in 17p-deleted lymphomas
(Project Heads
Chapuy, Björn
;
Eichhorst, Barbara
)
Completed projects
Aberrant CXCR4 signaling in lymphoma
(Project Head
Keller, Ulrich
)
Cellular approaches for the treatment of intestinal Graft-versus-Host disease and inflammatory bowel disease
(Project Heads
Maul, Jochen
;
Rieger, Kathrin
;
Uharek, Lutz
)
Gentransfer von Fusionscytokinen mit Spezifität für aberrant exprimierte Leukämiezellantigene in humane autologe CD8+ T-Zellen
(Project Heads
Notter, Michael
;
Thiel, Eckhard
)
Imaging and therapeutic targeting of oncogenic marks in lymphoproliferative malignancies
(Project Heads
Beer, Ambros
;
Keller, Ulrich
)
The role of deubiquitinating enzyme USP7 in the pathogenesis and treatment of acute myeloid leukemia
(Project Head
Krönke, Jan
)
Zweisignaltargeting von CD3-Antikörpern und T-Zellproduzierten Interlaukin (IL)-2-Fusionscytokinen gegen aberrante humane Leukämiezellantigene
(Project Heads
Notter, Michael
;
Thiel, Eckhard
)
Clinical Research Units
Completed projects
Intestinale Immunrekonstitution und Auswirkungen auf mukosale Infektionen nach allogener Knochenmark-/Blutstammzell-Transplantation
(Applicant
Uharek, Lutz
)
Major Research Instrumentation
Completed projects
In Vivo Imaging System for small animals
WBP Fellowship
Current projects
Proteomic characterization of measurable residual disease (MRD) in acute myeloid leukemia (AML)
(Applicant
Schmalbrock, Laura
)
CRC/Transregios
Completed projects
The Role of Cks1 for Cell Cycle Progession, p27kip1 functionality, Tumorigenesis and Tumor Dissemination
(Project Head
Keller, Ulrich
)
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