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Institution
Rheinische Friedrich-Wilhelms-Universität Bonn
Pharmazeutisches Institut
Pharmazeutische und Medizinische Chemie
Address
An der Immenburg 4
53121 Bonn
Deutschland
GERiT
This institution in GERiT
53121 Bonn
Projects
Research Grants
Current projects
Development of radiotracers targeting PURInoreceptor P2Y12, a promising target for positron emission tomography (PET) imaging of neuroinflammation
(Applicant
Müller, Christa E.
)
Discovery of BCL-2-selective degraders for applications in hematological malignancies
(Applicants
Krönke, Jan
;
Steinebach, Christian
)
Discovery of Chemical and Biological Tools for Reprogramming the Transcription Factor BCL6 Through Chemically Induced Proximity Modalities
(Applicants
Nowak, Ph.D., Radoslaw
;
Steinebach, Christian
)
Studies on the effects of carbapenems on leukocyte-endothelial cell interaction in models of pulmonary inflammation and viral infection
(Applicants
Fürst, Robert
;
Maier, Thorsten Jürgen
;
Müller, Christa E.
)
Completed projects
Design, Synthese und in vitro-Testung neuer nAChR-Liganden: Bioisostere der hochtoxischen Alkaloide (+)-Anatoxin-a, (-)-Ferruginin und (-)-Cytisin
(Applicant
Gündisch, Daniela
)
Ensemble Docking Interrogates Structural Determinants of Ligand-Protein Interactions
(Applicants
Beck-Sickinger, Annette G.
;
Schöneberg, Torsten
)
Molekulare Untersuchung und strukturelle Korrelation der bakteriziden Wirkung von Lantibiotika durch Einsatz kombinierter Biosensortechniken
(Applicants
Bendas, Gerd
;
Sahl, Hans-Georg
)
Research Units
Current projects
FOR 2685: The Limits of the Fossil Record: Analytical and Experimental Approaches to Fossilization
(Spokesperson
Gee, Carole T.
)
Searching for biological pigments and structural color in fossil plants
(Applicants
Gee, Carole T.
;
Müller, Christa E.
)
Completed projects
Development and characterization of heterocyclized dipeptide derivatives as inhibitors for heterotrimeric G proteins
(Applicant
Gütschow, Michael
)
Development and characterization of subtype-selective P2- purine and pyrimidine receptor ligands and investigation of their role in cell proliferation and differentiation.
(Applicant
Müller, Christa E.
)
FOR 2372: G protein signalling cascades: with new molecular probes and modulators towards novel pharmacological concepts
(Spokesperson
Kostenis, Evi
)
Medicinal chemistry of Gq proteins and their inhibitors: synthesis, computational calculations and (bio)analytical studies
(Applicant
Müller, Christa E.
)
Organic phase (extracellular matrix, osteocyte, blood vessel) preservation in dinosaur bone: Chemical composition and hypotheses of preservation
(Applicants
Müller, Christa E.
;
Tütken, Thomas
)
Reconstitution of Bacterial Targets in Model Membranes for a Biosensor-based Functional Analysis and Screening of Antibiotics
(Applicant
Bendas, Gerd
)
Collaborative Research Centres
Current projects
Synthesis, structural studies and characterization of ATP-hydrolyzing ectonucleotidase modulators
(Project Head
Müller, Christa E.
)
Completed projects
Interaktion von Membrangebundenen Serinproteasen mit Enzyminhibitoren
(Project Head
Gütschow, Michael
)
Research Fellowships
Completed projects
Synthesis, testing and evaluation of novel, non-steroidal inhibitors of the arachidonic acid pathway and the steroid hormone metabolism, respectively as potential anti-inflammatory and/or cancer chemopreventive agents
(Applicant
Liedtke, Andy Jürgen
)
Major Research Instrumentation
Completed projects
600 MHz NMR-Spektrometer
Triple-Quadrupol Mass spectrometer
WBP Fellowship
Current projects
Integration of two concepts in WNT signalling: Signalosome formation and Frizzled conformational dynamics
(Applicant
Voß, Jan Hendrik
)
Research Training Groups
Current projects
GRK 2873: Tools and Drugs of the Future - Innovative Methods and New Modalities in Medicinal Chemistry
(Spokesperson
Müller, Christa E.
)
Completed projects
GRK 677: Structure and Molecular Interaction as a Basis for Drug Action
(Spokesperson
Mohr, Klaus
)
GRK 804: Analysis of Cellular Functions by Combinatorial Chemistry and Biochemistry
(Spokesperson
Famulok, Michael
)
GRK 1873: Pharmacology of 7TM-Receptors and Downstream Signalling Pathways
(Spokesperson
Pfeifer, Alexander
)
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