SFB 1181:  Checkpoints for Resolution of Inflammation

• Subject Area: Medicine
• Term: from 2015 to 2024
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 261193037

Inflammation is the most important defense strategy of the body. Inflammation needs to be resolved, when no longer needed. Impaired resolution of inflammation leads to chronic diseases like arthritis, colitis and asthma. CRC1181 aims to define the mechanism of resolution of inflammation and to identify pathways that support the resolution process as well as those that overcome resolution and lead to chronicity of inflammation. In the last two funding periods we have defined critical nodes that control tissue specific resolution of inflammation. Furthermore, new methods have been developed that allow to study the dynamics of inflammation in vivo. In addition, therapeutic approaches have been discovered that foster resolution of immune-mediated inflammatory diseases. In the third funding period, we will leverage on (i) new insights in the immune metabolism during resolution of inflammation, (ii) therapeutic approaches to allow reset of inflammation and (iii) technologies that provide an unprecedented view in tissue changes during inflammation. To accomplish these goals CRC1181 has substantially restructured its team of scientists and has integrated new technologies. This strategy will push innovation and create new insights in the mechanisms and therapeutic approaches to stop inflammation in human disease during the third funding period.

• DFG Programme: Collaborative Research Centres

Current projects

• A01 - Characterization of the pro-resolving eosinophil subset in human arthritis and its regulation by anti-rheumatic treatment (Project Heads Bozec, Ph.D., Aline ;  Schett, Georg )
• A02 - Dissecting STAT6-regulated resolution of inflammation in the lung (Project Head Vöhringer, David )
• A03 - Glucocorticoid-mediated immune-metabolic reprogramming of macrophages during the resolution of inflammation (Project Head Krönke, Gerhard )
• A06 - Targeting immunometabolism and inflammasome for Coxiella burnetii elimination and resolution of Q fever (Project Heads Lang, Roland ;  Lührmann, Anja )
• A07 - Harnessing monocyte and dendritic cell dependent pathways of IVIg activity to enhance resolution of inflammation (Project Heads Dudziak, Diana ;  Nimmerjahn, Falk )
• B02 - Tec kinase ITK-dependent signaling pathways in the resolution of inflammation in ulcerative colitis (Project Heads Neurath, Markus F. ;  Weigmann, Benno )
• B06 - The role of Siglecs and sialic acids in the resolution of inflammation (Project Heads Nitschke, Lars ;  Steffen, Ulrike )
• B07 - Microbial-derived histamine induces resolution of synovial inflammation via the CNS (Project Heads Rothhammer, Veit ;  Zaiss, Mario M. )
• B08 - T cell-driven gut-lung interaction in the resolution of asthma (Project Heads Finotto, Ph.D., Susetta ;  Zundler, Sebastian )
• C02 - Resolution of inflammation in anti-TNF treatment refractory intestinal inflammation (Project Head Atreya, Raja )
• C04 - The resolution of chronic epithelial inflammation by L-arginine therapy (Project Heads Bogdan, Christian ;  Mattner, Jochen ;  Schleicher, Ulrike )
• C05 - Role of epithelial cell death for re-establishment of the gut barrier during resolution of intestinal inflammation (Project Head Becker, Christoph )
• C06 - The spatial transcriptomic landscape of resolution of inflammation in arthritis (Project Heads Ramming, Andreas ;  Rauber, Simon )
• MGKZ01 - Integrated Research Training Group (Project Heads Koop, Kristina ;  Zaiss, Mario M. )
• Z02 - Imaging (Project Heads Bäuerle, Tobias ;  Palmisano, Ralf ;  Sandoghdar, Ph.D., Vahid )
• Z03 - Central tasks of the CRC1181 (Project Head Schett, Georg )

Completed projects

• A04 - Manipulation of Pro- and Anti-Inflammatory Cytokine Production and Dysregulated Resolution of Inflammation by Helicobacter pylori (Project Head Backert, Steffen )
• A05 - Modification of cytokines by myeloperoxidase activity and (un)known mediators in resolution of psoriatic disease (Project Heads Frey, Silke ;  Hüffmeier, Ulrike ;  Steffen, Ulrike )
• A08 - Regulatory Networks that Control ILC2 Function in Acute and Chronic Inflammation (Project Heads Atreya, Ph.D., Imke ;  Wirtz, Stefan )
• B03 - Role of IDO in resolution of inflammatory autoimmune responses by CD83-induced regulatory mechanisms in arthritis (Project Head Steinkasserer, Alexander )
• B04 - Immunoregulatory Function of Human TCRαβ+ CD4-/CD8- Double Negative T cells and its Potential Role in Limiting Auto- and Alloreactive Immune Responses (Project Head Mackensen, Andreas )
• B05 - Deciphering Batf-dependent and independent inflammatory and regulatory T cell programs at mucosal surfaces (Project Head Hildner, Kai )
• C01 - Liver receptor homolog-1 (LHR-1) regulates inflammation-induced fibrotic tissue remodeling (Project Head Distler, Jörg Hans Wilhelm )
• C03 - Amplification of NET formation and neutrophil aggregation for the resolution of inflammation (Project Heads Herrmann, Martin ;  Hoffmann, Markus )
• C07 - The immune-metabolic basis of the DEL-1/αvβ3 integrin-dependent induction of resolving macrophages in the resolution of inflammatory arthritis (Project Head Chavakis, Triantafyllos )

• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Participating Institution: Max-Planck-Institut für die Physik des Lichts
• Spokesperson: Professor Dr. Georg Schett