Synthesis of membrane-permeable, bioreversible-protected second messenger and ATP-selective fluorescent chemosensors (A04)

• Subject Area: Organic Molecular Chemistry - Synthesis and Characterisation
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 335447717

This project aims at the further development and the extension of chemical routes for the synthesis of lipophilic, bioreversibly modified and/or photo-caged derivatives of the highly polar second messengers nicotinic acid adenine dinucleotide phosphate (MASTER-NAADP), (2’-deoxy)adenosine diphosphate-5-ribose ((2d)ADPR) and cyclic nucleoside monophosphates (cNMPs). Furthermore, bioinspired membrane-linked, fluorescent and ATP-selective chemosensors for the determination of ATP concentrations at cell surfaces will be developed. Thus, this project will address the central demand of the intracellular delivery and the detection of polyphosphorylated adenosine metabolites.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1328: Adenine Nucleotides in Immunity and Inflammation
• Applicant Institution: Universität Hamburg
• Project Head: Professor Dr. Chris Meier