SPP 1179:  Organocatalysis

• Subject Area: Chemistry
• Term: from 2005 to 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5472190

Organocatalysis is the catalysis of chemical reactions with small organic molecules. Typically, a metal is neither part of the catalytic principle, nor the substrate of the reaction. Traditionally, chemists have almost exclusively used metal-based catalysts. This surprises in light of the fact that half of all enzymes, nature s powerful catalysts, are metal-free. Only since very recently it has been generally realised that low-molecular weight, purely organic compounds can catalyse chemical reactions highly effectively and selectively. The goal of this Priority Programme is to develop new organocatalytic processes, to understand their mechanism, and to use organocatalytic methodology in synthesis.

• DFG Programme: Priority Programmes

Projects

• Aminkatalysierte direkte Aldol-Prozesse (Applicant Mahrwald, Rainer )
• Application of alpha,beta-foldamers as new organocatalysts (Applicant Reiser, Oliver )
• Asymmetric amination reactions with novel chiral ammonium salts (Applicant Bräse, Stefan )
• Asymmetric Organocatalysis with N-Heterocyclic Carbenes, Proline Derivatives and Bronsted Acids (Applicant Enders, Dieter )
• Asymmetrische Isomerisierung von meso-Cyclen mit bifunktionellen Katalysatoren erweiterten Reaktivitätsumfangs (Applicant Hintermann, Lukas )
• Bifunctional Organocatalysis: Asymmetric Addition of Nucleophiles to Cyclic Amino Acid Derivatives and to Epoxides (Applicant Berkessel, Albrecht )
• Bifunktionale Katalysatoren & Duale Organokatalyse (Applicant Glorius, Frank )
• Biokompatible Organokatalysatoren: Design und Anwendung in der chemoenzymatischen Eintopfsynthese (Applicants Berkessel, Albrecht ;  Gröger, Harald )
• Biomimetic carbene catalyzed oxidative activation of aldehydes (Applicant Studer, Armido )
• Cationic oligopeptides as new organocatalysts for reactions of anionic substrates under physiological conditions (Applicant Schmuck, Carsten )
• Chalkogenbasierte Organokatalyse: Mechanistische Untersuchungen und Design von Katalysatoren, deren Aktivität wesentlich durch Sauerstoff oder ein höheres Chalkogen bestimmt ist (Applicant Wessjohann, Ludger A. )
• Chiral mono- and bifunctional organic catalysts: A joint experimental-theoretical approach to asymmetric organic synthesis (Applicants Clark, Timothy ;  Tsogoeva, Svetlana )
• Concave acid/base-arrays for acid/base catalysis (Applicant Lüning, Ulrich )
• Cooperative and concurrent tandem organocatalysis (Applicant Schreiner, Peter R. )
• Design photoschaltbarer Organokatalysatoren, deren Immobilisierung und Anwendung auf chemische Oberflächenstrukturierung (Applicant Hecht, Stefan )
• Development and application of mass spectrometric methods for the investigation of organocatalytic reactions (Applicant Schrader, Wolfgang )
• Development of an organocatalytic Claisen rearrangement (Applicant Straßner, Thomas )
• Development of an organocatalytic Claisen rearrangement (Applicant Hiersemann, Martin )
• Development of new Brønsted acid catalyzed reactions and their application in the total synthesis of natural products and biologically active compunds (Applicant Rüping, Magnus )
• Diversity approach towards organocatalytic, asymmetric Mannich reactions (Applicant Westermann, Bernhard )
• Diversity approach towards organocatalytic, asymmetric Mannich reactions (Applicant Risch, Nikolaus )
• DMAP derivatives with improved selectivity (Applicant Zipse, Hendrik )
• Enantioselective domino reactions with chiral organocatalysts (Applicant Tietze, Lutz F. )
• Enantioselektive, Bronsted-Säure-kalalysierte, vinyloge Mannich- und Michael-Reaktionen (Applicant Schneider, Christoph )
• Entwicklungen neuer Strategien und Konzepte zur Lösung verbliebener Probleme der asymmetrischen Aminokatalyse (Applicant List, Benjamin )
• Helically chiral polyisocyanates and polyquinoxalines as organocatalysts (Applicant Reggelin, Michael )
• Hydrogen-Bond Mediated Catalysis by Chiral Bis-Amidinium Salts (Applicant Göbel, Michael )
• Immobilization of organocatalysts into core/shell nanofibers (Applicants Studer, Armido ;  Wendorff, Joachim H. )
• Immobilization of organocatalysts into core/shell nanofibers (Applicant Wendorff, Joachim H. )
• Integration carbenkatalytisch generierter Intermediate in organokatalytische Domino- und Kaskadenreaktionen (Applicant Zeitler, Kirsten )
• Investigation of catalysts incorporating metal-free Lewis acid centers (Applicant Wilhelm, René )
• KOORDINATORANTRAG im Rahmen des Schwerpunktprogramms 1179 "Organokatalyse" (Applicant List, Benjamin )
• Mass spectrometric investigation of organocatalyzed reactions (Applicant Metzger, Jürgen O. )
• Microencapsulated organocatalysts (Applicant Bolm, Carsten )
• New asymmetric catalysis of homogeneous organic transformations that take place within organic ion-pairs (Applicant Hintermann, Lukas )
• New organocatalysts for enantioselective Baylis-Hillman reactions and continuously operating reaction systems using supercritical reaction media (Applicant Leitner, Walter )
• Organo-catalytic asymmetric synthesis of cannabinoids (Applicant Bräse, Stefan )
• Organocatalysis: Catalysts and Uncommon Reaction Conditions (Applicant Bolm, Carsten )
• Organocatalysts with Spectator Metals (Applicant Gladysz, John A. )
• Organocatalytic Domino Michael-Aldol Reactions for the Construction of Heterocyclic Natural Products (Applicant Bräse, Stefan )
• Organokatalysator-Triazoliumsalz-Konjugate als neue Ionic Liquid-Tagged Organokatalysatoren (Applicant Liebscher, Jürgen )
• Physikalische Grundlagen nukleophiler Organokatalyse (Applicant Mayr, Herbert )
• Rapid Access to Structural Complexity by Organocatalytic Cyclizations of Polyfunctional Molecules (Applicant Christmann, Mathias )
• Short peptide and peptide-like organic catalysts: A joint experimental-theoretical approach to asymmetric organic synthesis (Applicant Schmatz, Stefan )
• Strongly acidic Brønsted acids as efficient catalysts in asymmetric synthesis (Applicant Rüping, Magnus )
• Strukturaufklärung alpha/beta peptidischer Organokatalysatoren (Applicant Gschwind, Ruth M. )
• Synthesis of novel chiral anions and their application in organocatalytic reactions (Applicant Leitner, Walter )
• Wasserstoffbrücken-vermittelte Enantioselektivität in organokatalytischen Photoreaktionen (Applicant Bach, Thorsten )

• Spokesperson: Professor Dr. Benjamin List