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Institution
Julius-Maximilians-Universität Würzburg
Biozentrum der Universität Würzburg
Lehrstuhl für Biotechnologie und Biophysik
Address
Am Hubland
97074 Würzburg
Deutschland
GERiT
This institution in GERiT
97074 Würzburg
Projects
Independent Junior Research Groups
Current projects
A Novel Approach in Neuropharmacology: Targeting GABA(A)R-Associated Proteins
(Applicant
Maric, Hans Michael
)
Completed projects
Untersuchung des Typ I Protein Export Apparates und der Efflux-Pumpen Gram-negativer Bakterien
(Applicant
Andersen, Christian
)
Research Grants
Current projects
Combining genetic code expansion and bioorthogonal click labeling with deep learning and particle averaging for improved super-resolution imaging
(Applicants
Kollmannsberger, Philip
;
Sauer, Markus
)
Development of a selective antimicrobial cystic fibrosis therapy approach
(Applicants
Fischer, Dagmar
;
Maric, Hans Michael
;
Vogel, Jörg
)
Elucidation and control of the mechanism of uptake and intracellular distribution of peptidic drugs bound in redox-sensitive nanogels in Caco2 cells as a model for small intestinal enterocytes
(Applicant
Groll, Jürgen
)
Investigating humoral autoimmunity against the NMDA receptor GluN1 subunit by super-resolution fluorescence microscopy: effects on synapse integrity and function
(Applicants
Doose, Sören
;
Geis, Christian
)
Structure and dynamics of a folding intermediate of a spidroin C-terminal domain
(Applicants
Hellmich, Ute
;
Neuweiler, Hannes
)
Completed projects
Conformational dynamics of an ABC exporter investigated by NMR spectroscopy and PET fluorescence quenching
(Applicants
Hellmich, Ute
;
Neuweiler, Hannes
)
Der Einfluss von Reibung auf Proteindynamik
(Applicant
Doose, Sören
)
Die Kettendynamik eines entfalteten Proteins
(Applicant
Neuweiler, Hannes
)
Die Synthese neuartiger lipophiler Ionen und vergleichende Untersuchungen ihrer Wechselwirkung mit tierischen, pflanzlichen und künstlichen Lipid-Membranen
(Applicant
Schenk, Wolfdieter A.
)
Dynamics of local presynaptic protein synthesis of active zone components in spinal motoneurons
(Applicants
Sauer, Markus
;
Sendtner, Michael A.
)
Feld-induzierte Membran- und Zytosolprozesse: Untersuchungen in der Frequenz- (kHz - 200 MHz Bereich) und Zeitdomäne (Nano- bis Mikrosekundenbereich)
(Applicant
Zimmermann, Ulrich
)
Interdisciplinary Analysis of Fungal Rhodopsins and Their Physiological Function in Mycelia.
(Applicant
Terpitz, Ulrich
)
Untersuchung der Photoschädigung bei der hoch aufgelösten Lebendzell-Fluoreszenzmikroskopie
(Applicant
Sauer, Markus
)
Untersuchungen zum Mechanismus der beta-Hairpin Faltung mittels Kombination von Fluoreszenzspektroskopie und Computersimulation
(Applicants
Sauer, Markus
;
Smith, Jeremy Christopher
)
Vergleich und Verbesserung der Genauigkeit von Abstandsmessungen mittels EPR und FRET im Bereich von 1 bis 10 nm unter Nutzung formtreuer Oligo(phenylenethinylen)e und verwandter Verbindungen
(Applicant
Sauer, Markus
)
Priority Programmes
Current projects
Cooperative pathogenicity of enteropathogenic E. coli (EPEC) within mucosa-attached microcolonies
(Applicants
Dupont, Ph.D., Aline
;
Saliba, Antoine-Emmanuel
;
Sauer, Markus
)
Completed projects
Analysis of the 3D-nuclear-nanostructure in human Cells using Fluorescence Detection of Multiplex Dyes
(Applicant
Cremer, Christoph
)
Investigation of structure and function of the COPI-System using single, on nanostructures immobilised molecules and fluorescence resonance energy transfer (FRET)
(Applicant
Wieland, Felix Wilhelm Theodor
)
Collaborative Research Centres
Completed projects
Assembly, functional dynamic and regulation of the multi-heteromeric protein complex vacuolar H+-ATPase
(Project Heads
Dietz, Karl-Josef
;
Sauer, Markus
;
Seidel, Thorsten
)
Functional dynamics of transmembrane proteins studied by surface-enhanced FTIR spectroscopy and single molecule fluorescence imaging
(Project Heads
Heberle, Joachim
;
Sauer, Markus
)
Investigation of the molecular mechanism of a circadian "slave"oscillator using single-molecule fluorescence spectroscopy and imaging
(Project Heads
Sauer, Markus
;
Staiger, Dorothee
)
Molecular Recognition of Ice Surfaces by Antifreeze Glycoproteins and Synthetic Analogues
(Project Heads
Doose, Sören
;
Koop, Thomas
;
Sewald, Norbert
)
Strukturierte Immobilisierung einzelner Biomoleküle auf Glasoberflächen mit Submikrometerpipetten
(Project Head
Sauer, Markus
)
Research Units
Current projects
FOR 3004: Synaptic pathology in autoimmune encephalitis – SYNABS
(Spokesperson
Geis, Christian
)
LGI1 antibody induced pathophysiology at axon initial segments and presynaptic nerve terminals
(Applicants
Hallermann, Stefan
;
Sauer, Markus
)
Completed projects
Analysis of the functional relevance of sphingomyelinases and ceramide in meningococcal pathogenesis
(Applicants
Sauer, Markus
;
Schubert-Unkmeir, Alexandra
)
FOR 2123: Sphingolipid Dynamics in Infection Control
(Spokesperson
Schneider-Schaulies, Sibylle
)
Major Research Instrumentation
Completed projects
Mikroskopsystem mit 4 Lasern und Modul für strukturierte Beleuchtung (SIM)
Zeitaufgelöstes Fluoreszenzmikroskop
CRC/Transregios
Current projects
Interaction of Aspergillus fumigatus with human natural killer cells
(Project Heads
Einsele, Hermann
;
Löffler, Jürgen
;
Terpitz, Ulrich
)
In vivo analysis of temporal and spatial disease progression and immune cell interaction during invasive Aspergillus fumigatus infection
(Project Heads
Beilhack, Andreas
;
Brock, Matthias
;
Heinze, Katrin G.
;
Terpitz, Ulrich
)
Super-resolution microscopy to visualize CAR-T cell receptome and function
(Project Heads
Nerreter, Thomas
;
Sauer, Markus
)
Completed projects
Activity-induced ionotropic glutamate receptor dynamics at super-resolution in vivo
(Project Heads
Kittel, Robert J.
;
Sauer, Markus
)
Enlightening inhibitory neurotransmitter receptor organization and dynamics applying high end microscopy
(Project Heads
Heintzmann, Rainer
;
Maric, Hans Michael
;
Qualmann, Britta
)
Genetic code expansion and bioorthogonal click labeling for super-resolution imaging of receptors with molecular resolution
(Project Heads
Heintzmann, Rainer
;
Kollmannsberger, Philip
;
Sauer, Markus
)
Investigating humoral autoimmunity against the NMDA-receptor NR1 subunit by super-resolution fluorescence microscopy: effects on synapse integrity and function
(Project Heads
Doose, Sören
;
Geis, Christian
)
Mechanisms of platelet receptor regulation and disintegration
(Project Heads
Nieswandt, Bernhard
;
Sauer, Markus
)
Research Training Groups
Current projects
GRK 2157: 3D Tissue Models for Studying Microbial Infections by Human Pathogens
(Spokesperson
Rudel, Thomas
)
Completed projects
GRK 1342: Molecular and Functional Analysis of Lipid-based Signal Transduction Systems
(Spokesperson
Müller, Martin J.
)
GRK 2581: Metabolism, topology and cx)mpartmentalization of membrane proximal lipid and signaling components in infection
(Spokesperson
Seibel, Jürgen
)
Graduate Schools
Completed projects
GSC 106: Graduate School for Life Sciences (GSLS)
(Spokesperson
Kisker, Caroline
)
Additional Information
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