Project Details

Professor Dr. Wolfgang Sippl

Address Martin-Luther-Universität Halle-Wittenberg
Institut für Pharmazie
Abteilung Medizinische Chemie
Wolfgang-Langenbeck-Straße 4
06120 Halle

Projects

As Applicant
- Current projects
  - Development of fragment-based inhibitors of the bacterial deacetylase LpxC as novel antibiotics (Research Grants)
  - Molecular Design, Synthesis, and Pharmacology of Novel and Selective Histone Deacetylae 10 (HDAC10) Inhibitors (Research Grants)
  - Development and biological characterization of dual-targeting inhibitors against the apicomplexan parasite Plasmodium falciparum (Research Grants)
  - Synthesis and pharmacology of novel inhibitors of histone deacetylases and of proteolysis targeting chimeras (PROTACs) for mutant FMS-like tyrosine kinase-3 (Research Grants)
  - Sirtuin-2 (Sirt2) ligands as inhibitors of lysine long-chain deacylation and chemical tools for protein degradation (Research Grants)
  - Targeting oncofetal IGF2BP proteins by small molecule drugs in cancer (Research Units)
  - Molecular Design, Synthesis, and Pharmacology of Targeted Protein Degraders for the Checkpoint Kinase ATR (Research Grants)
  - Dual-targeting WEE1/AURK-A kinase proteolysis targeting chimera (PROTAC) for cancer therapy (Research Grants)
- Completed projects
  - Hemmstoffe NAD+-abhängiger Histon-Desacetylasen (Sirtuine) (Research Grants)
  - Target basierte Entwicklung neuer Hemmstoffe der Lysin-Dementhylase LSDI und deren Einfluss auf die Regulation des Androgenrezeptors (Research Grants)
  - Selektive Proteinkinase-Inhibitoren als Wirkstoffe gegen Neurodegeneration (Research Grants)
  - NAD+-abhängige Transferasen und deren Inhibitoren (Research Grants)
  - Mit neuartigen Wirkstoffen zu neuen Ansätzen bei der rezeptorvermittelten Tumorresistenz (Research Grants)
  - Structure based development and biological characterization of selective inhibitors of histone deacetylases (HDACs) 8 and 10. (Research Grants)
  - Isotype selective sirtuin inhibitors (Research Grants)

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Professor Dr. Wolfgang Sippl

Additional Information

Servicenavigation

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Professor Dr. Wolfgang Sippl

Additional Information

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