The function of the Ubiquitin-Proteasome-System (UPS) in MHC class I antigen processing in target cells and maturing human dendritic cells (hDCs).

• Applicant: Professor Dr. Peter Michael Kloetzel
• Subject Area: Immunology
• Term: from 2009 to 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 105348415

• Final Report Year: 2012

Final Report Abstract

No abstract available

Publications

• Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress. Cell 142, 613-622 (2010)
  Seifert, U., Bialy, L.P., Ebstein, F., Bech-Otschir, D., Voigt, A., Schröter, F., Prozorovski, T., Lange, N., Steffen, J., Rieger, M., Kuckelkorn., U, Aktas, O., Kloetzel, P.M., Krüger, E.
  
• Emerging roles of immunoproteasomes beyond MHC class I antigen Cell Mol Life Sci. 69, 2543-2558 (2012)
  Ebstein F, Kloetzel PM, Krüger E, Seifert U
  
• Immunoproteasomes at the interface of innate and adaptive immune responses: two faces of one enzyme. Curr Opin Immunol. 24, 77-83. (2012)
  Krüger E, Kloetzel PM
  (See online at https://doi.org/10.1016/j.coi.2012.01.005)
• The FAT10 and ubiquitin-dependent degradation machineries exhibit common and distinct requirements for MHC class I antigen presentation Cell Mol Life Sci 69, 2443-24454 (2012)
  Ebstein F, Lehmann A, Kloetzel PM
  (See online at https://doi.org/10.1007/s00018-012-0933-5)