Identification of susceptibility gene(s) controlling autoantibody production in collagen induced arthritis

• Applicant: Professor Dr. Saleh M. Ibrahim
• Subject Area: Rheumatology ; Immunology
• Term: from 2009 to 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 107048602

• Final Report Year: 2013

Final Report Abstract

The primary aim of the project has been the identification of the gene underlying the Quantitative Trait Locus, QTL, Cia27. Cia27 was previously identified by our group as a locus controlling autoantibody production and onset of arthritis. In silico fine mapping, Gene expression studies, sequencing analysis and congenic mapping approaches were performed to fine map the QTL. Thrap2 was then identified as the candidate QT gene. Subsequently, functional analysis of Thrap2 indicated a potential role for the gene in controlling B cell survival, consequently controlling autoantibody production and autoimmunity.

Publications

• Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis. Arthritis Research & Therapy 2011, 13:132
  Yu Xand Ibrahim SM