Project Details
Projekt
Nox4-dependent mechanisms in neuropathic pain and pruritus signaling cascades (A14)
Subject Area
Pharmacology
Term
from 2009 to 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 61867463
In this research project we will characterize Nox4-dependent pathways in sensory neurons after peripheral nerve injury and during itch processing. For this purpose, we will characterize the expression and function of potential Nox4 downstream targets (S100A4 and ApoE) in the peripheral nerve system, and we will investigate Nox4-dependent regeneration processes after peripheral nerve injury. Furthermore, we will characterize Nox4/cGKIα-dependent redox signaling during itch processing. The major goal is to establish new therapeutic approaches for the treatment of neuropathic pain and pruritus.
DFG Programme
Collaborative Research Centres
Applicant Institution
Goethe-Universität Frankfurt am Main
Project Heads
Professor Dr. Gerd Geißlinger, until 12/2016; Dr. Wiebke Kallenborn-Gerhardt
