Construction of novel hybrid biooligomers as artificial SNAREs to dissect the mechanism of SNAREs in membrane docking and fusion (B05)

• Subject Area: Biophysics
• Term: from 2009 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 55908123

Synthetically generated SNARE analogs are used to examine the mechanism of the neuronal SNARE mediated fusion process. The recognition domain of the SNARE motif, the transmembrane domains, and the linker region will be specifically modified. Docking/hemifusion and fusion processes can be individually addressed using our SNARE analogs. The influence of membranes varying in lipid composition will be investigated with respect to the SNARE analog-mediated fusion processes.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 803: Functionality Controlled by Organisation in and between Membranes
• Applicant Institution: Georg-August-Universität Göttingen
• Co-Applicant Institution: Max-Planck-Institut für biophysikalische Chemie; (Karl-Friedrich-Bonhoeffer-Institut) (aufgelöst)
• Project Heads: Professor Dr. Ulf Diederichsen (†); Professor Dr. Reinhard Jahn