Regulation of epidermal morphogenesis and barrier function by intercellular junctions (A01)

• Subject Area: Dermatology
• Term: from 2009 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 73111208

We have demonstrated that classical cadherins through regulation of intercellular junctions, the cytoskeleton and kinase signaling are crucial for the formation and structural integrity of the epidermal barrier. The overall goal of this project is to unravel the mechanisms by which intercellular junctions cooperate to regulate the formation, maintenance and restoration of tissue architecture, integrity and epidermal barrier function.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 829: Molecular Mechanisms Regulating Skin Homeostasis
• Applicant Institution: Universität zu Köln
• Project Head: Professorin Dr. Carien Niessen, Ph.D.