Project Details
Projekt
Metabolic control of skin morphogenesis, barrier function and development of diabetes associated skin complications (A05)
Subject Area
General Genetics and Functional Genome Biology
Dermatology
Dermatology
Term
from 2009 to 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 73111208
In the last funding periods we identified novel functions for skin insulin/IGF/FoxO metabolic signalling in the regulation of stem cells, skin DNA repair, inflammation and barrier function. We will now ask how Insulin/FoxO signalling controls skin barrier function, examine how skin insulin resistance contributes to skin associated pathology in type 2 diabetes and address the role of neuronal insulin signalling in skin function and diabetic skin complications.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität zu Köln
Project Heads
Professor Dr. Jens Claus Brüning; Professorin Dr. Carien Niessen
