Metabolic control of skin morphogenesis, barrier function and development of diabetes associated skin complications (A05)

• Subject Area: General Genetics and Functional Genome Biology ; Dermatology
• Term: from 2009 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 73111208

In the last funding periods we identified novel functions for skin insulin/IGF/FoxO metabolic signalling in the regulation of stem cells, skin DNA repair, inflammation and barrier function. We will now ask how Insulin/FoxO signalling controls skin barrier function, examine how skin insulin resistance contributes to skin associated pathology in type 2 diabetes and address the role of neuronal insulin signalling in skin function and diabetic skin complications.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 829: Molecular Mechanisms Regulating Skin Homeostasis
• Applicant Institution: Universität zu Köln
• Project Heads: Professor Dr. Jens Claus Brüning; Professorin Dr. Carien Niessen, Ph.D.