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Genetic analysis of epidermal development and homeostasis in zebrafish (A09)

Subject Area General Genetics and Functional Genome Biology
Developmental Biology
Term from 2009 to 2020
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 73111208
 
Using zebrafish genetics, we have identified a p53/p63-Notch-Caspase 3 pathway regulating epidermal renewal by promoting both terminal keratinocyte differentiation / shedding at the surface and keratinocyte proliferation in basal layers, as well as a Na/K-ATPase as a novel tumour suppressor and hypotonic stress as a novel tumour-risk factor, causing epidermal malignancy via aberrant activation of a PI3K-mTORC1-NFkB pathway. Future research aims to identify upstream and downstream components of identified pathways, and more chemicals to treat corresponding diseases.
DFG Programme Collaborative Research Centres
Applicant Institution Universität zu Köln
 
 

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