Project Details
Projekt
Role of MMP-14 in connective tissue homeostasis and tumour invasion (B04)
Subject Area
Dermatology
Term
from 2009 to 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 73111208
Based on the results of the previous funding period we now want to understand how membrane-associated MMP-14 contributes to the progression of epithelial and non-epithelial tumors of the skin, to vascular functionality and how it influences the response to therapy. We will also use the inducible endothelial cell and fibroblast-specific knockout mouse strains which we have generated to further analyse the influence of matrix alterations induced by MMP-14 ablation in tissue homeostasis and disease.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität zu Köln
Project Heads
Professorin Dr. Cornelia Mauch; Paola Zigrino, Ph.D., since 1/2017
