Analysis of the inflammatory bowel disease susceptome and resistome using a forward genetics approach

Applicant Dr. Katharina Brandl

Subject Area Gastroenterology

Term from 2009 to 2011

Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 112578275

Final Report Year 2011

Final Report Abstract

No abstract available

Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Proc Natl Acad Sci U S A, 2009 Mar 3;106(9):3300-5
Brandl K., Rutschmann S., Li X., Du X., Xiao N., Schnabl B., Brenner D.A. and Beutler B.
NOD2 Regulates Dendritic Cell Function during Graft-versus-host Disease. Journal of Experimental Medicine, 2009; Sep 28;206(10):2101-10
Penack O., Smith O.M., Cunningham-Bussel A., Liu X., Rao U., Yim N., Na I., Holland A.M., Ghosh A., Lu S.X., Jenq R.R., Liu C., Murphy G.F., Brandl K., van den Brink M.R.M.
The Tpl2 mutation Sluggish impairs type I IFN production and increases susceptibility to group B streptococcal disease. Journal of Immunology. 2009; Dec 15;183(12):7975-83
Xiao N., Eidenschenk C., Krebs P., Brandl K., Blasius A.L., Xia Y., Khovananth K., Smart N.G., Beutler B.
MyD88-mediated signals in non-hematopoietic cells protect mice against DSS induced colitis by inducing specific EGFR ligands. Proc Natl Acad Sci U S A, 2010 Nov 16;107(46):19967-72
Brandl K., Sun L., Neppl C., Siggs O.M., Le Gall S.M., Tomisato W., Li X., Du X., Maennel D.N., Blobel C.P., Beutler B.