ERA NanoSci - Magnetic nanoparticles for nerve regeneration

• Applicant: Professorin Dr. Gerburg Keilhoff
• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells ; Theoretical Chemistry: Electronic Structure, Dynamics, Simulation
• Term: from 2009 to 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 119418337

Bioengineering research is exploring molecular and cell therapies alternative to surgical nerve grafting for the treatment of severe peripheral nerve injuries. However, to date there has been no progress of undoubted clinical benefit. The recent advances in nanoscience may provide new therapeutic possibilities as alternatives/supplements to established surgical techniques. Specifically, the MARVENE project is concerned with the use of magnetic nanoparticles (MNPs) as functional nano-objects to enhance the nerve regeneration and provide guidance for the regenerating axons. MNPs could open the frontiers for new therapies based on the exploitation of the mechanical forces acting on MNPbound neurons to promote axonal elongation/growth. Furthermore, the realization of MNPs functionalised with neurotrophic factors offer distinct possibilities for novel molecular therapy and when bound to mesenchymal stem cells, MNPs may form the basis for more effective cell therapy.

• DFG Programme: Research Grants
• International Connection: Italy, Spain, United Kingdom
• Participating Persons: Dr. Gerardo Goya; Dr. Vittoria Raffa; Dr. Lijun Wang