Function of adult generated olfactory bulb interneurons
Final Report Abstract
In the second funding period the generation of sufficient numbers of transgenic animals became increasingly difficult. However, we could successfully move the involved staff to other projects on synaptic processing in the olfactory bulb and on the output of single neural stem cells in young animals where they excelled with very good publications. Since the Egger group was very much intrigued by the discovered dendrosomatic clasping structures in the dendrites of dopaminergic glomerular neurons in the first funding period of the project, we decided to test alternative approaches in the second funding period. We also developed techniques to analyse dendritic morphology in 3D relative to the glomeruli. These renewed efforts allowed us to gather sufficient data for a neuroanatomical publication on dopaminergic and other glomerular neurons. In the second funding period experimental progress in the Ninkovic group was according to the research plan.
Publications
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(2015) Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone. Nat Neurosci 18, 490-492
Calzolari F, Michel J, Baumgart EV, Theis F, Götz M, Ninkovic J
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(2015) Local postsynaptic voltage-gated sodium channel activation in dendritic spines of olfactory bulb granule cells. Neuron 85, 590-601
Bywalez WG, Patirniche D, Rupprecht V, Stemmler M, Herz AVM, Pálfi D, Rózsa B, Egger V
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Physiology of rodent olfactory bulb interneurons, Ludwig-Maximilians-Universität München, GSN 2015
Bywalez WG
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(2016) Identifying the progeny of single neural stem cells in the adult murine forebrain. LMU München, Faculty of Medicine
Michel J
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(2017) Dendritic arborization patterns of small juxtaglomerular cell types within the rodent olfactory bulb. Frontiers in Neuroanatomy 10:127
Bywalez WG, Ona-Jodar T, Lukas M, Ninkovic J, Egger V
