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SFB 656:  Molecular Cardiovascular Imaging (MoBil) - From Mouse to Man

Subject Area Medicine
Biology
Chemistry
Computer Science, Systems and Electrical Engineering
Mathematics
Term from 2005 to 2017
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 12467772
 
Final Report Year 2017

Final Report Abstract

The Collaborative Research Centre CRC 656 ‘Molecular cardiovascular imaging’ was initiated at the University of Münster (Westfälische Wilhelms-Universität Münster, WWU) with the aim to develop and establish novel molecular imaging approaches for studying functional and molecular aspects of cardiovascular diseases and their clinical sequelae. A particular emphasis was put on developing molecular imaging towards bridging preclinical models of human pathologies and clinical disease, in scenarios such as atherosclerosis, myocardial infarction or arrhythmia and cardiomyopathies. Already from the start the scientific concept was based on a strong inter-faculty co-operation between the faculties of medicine, chemistry and pharmacy, physics and mathematics and computer sciences and the Max Planck Institute for Molecular Biomedicine in Münster in the areas of preclinical models and translational research, organic chemistry and radiochemistry, detector physics and image reconstruction and processing. With its research topic and inter-faculty setup, CRC 656 was the first dedicated imaging CRC funded by the DFG. Scientists of CRC 656 successfully worked on various projects and published distinguished scientific results and patents in the various areas of CRC 656 research. CRC 656 has fostered basic research by developing and applying novel molecular imaging technologies as well as first examples of the translational potential of these approaches to interrogate cardiovascular diseases. These scientific results have been discussed in three international Molecular Imaging Schools organised by CRC 656, where PIs of our CRC interacted with internationally recognized scientists from all relevant research areas. At the same time, CRC 656 has driven a broad interdisciplinary and inter-faculty network at WWU that has successfully overcome pre-existing faculty borders. This was realised through interdisciplinary multi-PI projects as well as interdisciplinary supervision of doctoral students and their projects. The cross-faculty approach of CRC 656 has been the basis for the establishment of new structures at WWU, e.g. the European Institute for Molecular Imaging – EIMI as a central interdisciplinary research unit, which further promoted the inter-faculty endeavour of CRC 656 as well as laid the basis for new and even broader research networks. Amongst others, the successful application for the DFG Cluster of Excellence ‘Cells in Motion – CiM’ picked up the idea of CRC 656 to use imaging to bridge scales and fields and expanded it to high resolution approaches and a broader biomedical field. In addition, CRC 656 has developed a strong public outreach programme, which targeted scholars, school teachers and the public through a broad range of talks, workshops and interactive exhibitions. These activities were funded in one of the early Ö-projects in a CRC in Germany. In summary, CRC 656 has largely accomplished its scientific mission, has promoted new inter-faculty structures and thereby significantly contributed to the international scientific visibility and attractiveness of WWU.

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