The role of TRPC1 C4 C5 C6 and related proteins for Ca2+ signaling in mast cells

• Applicant: Professor Dr. Marc Freichel
• Subject Area: Dermatology
• Term: from 2009 to 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 124742924

• Final Report Year: 2019

No abstract available

Publications

• TRPM4-mediated control of FcεRI-evoked Ca(2+) elevation comprises enhanced plasmalemmal trafficking of TRPM4 channels in connective tissue type mast cells. Sci Rep. 2016;6:32981
  Rixecker, Torben; Mathar, Ilka; Medert, Rebekka; Mannebach, Stefanie; Pfeifer, Alexander; Lipp, Peter; Tsvilovskyy, Volodymyr & Freichel, Marc
  
• Deletion of Orai2 augments endogenous CRAC currents and degranulation in mast cells leading to enhanced anaphylaxis. Cell Calcium. 2018;71:24-33
  Tsvilovskyy, Volodymyr; Solís-López, Alejandra; Schumacher, Dagmar; Medert, Rebekka; Roers, Axel; Kriebs, Ulrich & Freichel, Marc