Funktionelle Charakterisierung von LRRK2, ursächlich für familiäre Parkinsonsche Erkrankung (Park8) und Herstellung transgener Mausmodelle

• Applicant: Dr. Saskia Biskup
• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2005 to 2007
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 13348773

• Final Report Year: 2008

Final Report Abstract

No abstract available

Publications

• Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16842-7
  West AB, Moore DJ, Biskup S, Bugayenko A, Smith WW, Ross CA, Dawson VL, Dawson TM
  
• Detrimental deletions: mitochondria, aging and Parkinson's disease. Bioessays. 2006 Oct;28(10):963-7
  Biskup S, Moore DJ
  
• Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mousebrain. J Neurochem. 2006 Nov 13
  Higashi S, Moore DJ, Colebrooke RE, Biskup S, Dawson VL, Arai H, Dawson TM, Emson PC
  
• Localization of LRRK2 to membranous and vesicular structures in mammalian brain. Ann Neurol. 2006 Nov 21; 60(5):557-569
  Biskup S, Moore DJ, Celsi F, Higashi S, West AB, Andrabi SA, Kurkinen K, Yu SW, Savitt JM, Waldvogel HJ, Faull RL, Emson PC, Torp R, Ottersen OP, Dawson TM, Dawson VL
  
• Dynamic and redundant regulation of LRRK2 and LRRK1 expression. BMC Neurosci. 2007 Nov 28;8:102
  Biskup S, Moore DJ, Rea A, Lorenz-Deperieux B, Coombes CE, Dawson VL, Dawson TM, West AB
  
• Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain. Brain Res. 2007 Apr 19
  Higashi S, Biskup S, West AB, Trinkaus D, Dawson VL, Faull RL, Waldvogel HJ, Arai H, Dawson TM, Moore DJ, Emson PC
  
• Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity. Hum Mol Genet. 2007 Jan 15
  West AB, Moore DJ, Choi C, Andrabi SA, Li X, Dikeman D, Biskup S, Zhang Z, Lim KL, Dawson VL, Dawson TM