GRK 1628:  Selektivität in der Chemo- und Biokatalyse

• Fachliche Zuordnung: Molekülchemie
• Förderung: Förderung von 2010 bis 2019
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 135945478

• Erstellungsjahr: 2019

Zusammenfassung der Projektergebnisse

Selectivity in catalyzed transformations of substrates is an essential feature for the sustainable (“green”) production of chemicals. This becomes particularly critical when feedstocks for raw materials will shift from conventional fossil sources (coal, petroleum) to biorenewable sources and possibly to carbon dioxide. The understanding and rational design of catalysts – both chemical and biological – requires a venture into new systems. The International Research Training Program “Selectivity in Chemo- and Biocatalysis (SeleCa)” was established at RWTH Aachen University in 2010. It aims at the understanding of efficient and selective catalytic reactions on the molecular level of both homogeneous and biological (enzymatic) catalysts. Simultaneously, the Japanese German Graduate Externship Program on “Environmentally Benign Bio- and Chemical Processes“ funded by the Japan Society for the Promotion of Science (JSPS) was established at Osaka University’s Department of Engineering and Department of Engineering Science. Interdisciplinary and transnational research in areas of both chemical and enzymatic catalysis has been performed in a unique international collaborative approach. The cooperation involved twelve groups from RWTH Aachen University along with two associated groups each from Research Centre Jülich and eleven groups from Osaka University. Graduate students both of chemistry and biotechnology were involved in joint projects including: metal catalysis (selective catalytic functionalization of aromatic substrates; efficient and selective formation of carbon-carbon and carbon-heteroatom bonds; bimetallic redox-active biomimetic catalysts for selective C-H bond functionalization and switchable polymerization; development of novel bifunctional organocatalysts), supramolecular catalysis (selective hydrogenation catalysts based on molecular recognition), biocatalysis (identification, biochemical, and functional characterization of novel biocatalysts; new glycosynthases; selective production and analysis of poly(γ-glutamic acid) with distinct molecular weight distribution and composition), biohybrid catalysis (hybrid biocatalysts for selective polymerizations; non-heme protein models for biomimetic oxidation reactions; multifunctional polyethers through chemical and enzymatic catalysis). Despite the great geographical distance, the scientific exchange activity and interactions were generally intense, amicable, and fruitful throughout the entire funding period. As a particularly successful collaboration between chemistry and biotechnology as well as between Aachen/Jülich and Osaka, the area of biohybrid catalysts or so-called artificial metalloenzymes and whole-cell catalysts contributed to a timely and highly competitive research field. Over the past nine years, joint symposia with eminent international guest speakers, including Nobel laureates, were annually held both in Aachen and Osaka (in total 18). The graduate students were encouraged to organize and execute these formal scientific events in a responsible manner. In addition, graduate students completed mutual research stays of up to one year at both universities and participated in lecture courses, regular research seminars, specialized workshops and excursions to companies. Additional soft skills, including safeguarding good scientific practice, gender issues, Japanese language/culture, and project management were acquired. Despite the difference in regulations in three separate faculties, joint doctoral defense examinations were also realized both in Aachen and Osaka. This has ensured direct comparison of the scientific standard of dissertations in the partner institutions and triggered discussions on the nature of the doctoral examination within the RWTH faculty. In total, 46 doctoral dissertations were successfully concluded, and 218 papers were published, in addition to >300 poster and oral presentations at national and international conferences. It is believed that at the end of this nine years’ program, substantial internationalization has been realized by educating graduate students who are knowledgeable in both chemo- and biocatalysis and cross-cultural experience. Graduates of this IRTG are well prepared for employment in a more interdisciplinary and rapidly globalizing labor market.

Projektbezogene Publikationen (Auswahl)

• C–H Bond Activation of N-Heterocyclic Carbene IMes by Rare-earth Metal Alkyl Complexes. J. Organomet. Chem. 2010, 695 (25), 2794-2797
  Fegler, W.; Saito, T.; Mashima, K.; Spaniol, T. P.; Okuda, J.
  
• N-Heterocyclic Carbene Catalysed Asymmetric Cross-benzoin Reactions of Heteroaromatic Aldehydes with trifluoromethyl ketones. Chem. Commun. 2010, 46 (34), 6282-6284
  Enders, D.; Grossmann, A.; Fronert, J.; Raabe, G.
  
• Copper- Catalyzed Direct Sulfoximination of Azoles and Polyfluoroarenes under Ambient Conditions. Org. Lett. 2011, 13, 359–361
  Miyasaka, M.; Hirano, K.; Satoh, T.; Kowalczyk, R.; Bolm, C.; Miura, M.
  
• Design and Synthesis of Supramolecular Tetrahedra, 12.2011
  Shang, Yuli
  
• Dual Secondary Amine/N- Heterocyclic Carbene Catalysis in the Asymmetric Michael/Cross-Benzoin Cascade Reaction of β-Oxo Sulfones with Enals. Eur. J. Org. Chem. 2011, 2011 (23), 4298-4301
  Enders, D.; Grossmann, A.; Huang, H.; Raabe, G.
  
• Post-polymerization Functionalization of Linear Polyglycidol with Diethyl Vinylphosphonate. Chem. Commun. 2011, 47 (28), 8148-8150
  Köhler, J.; Keul, H.; Möller, M.
  
• “Induced Fit” in Chiral Recognition: Epimerization upon Dimerization in the Hierarchical Self-Assembly of Helicate-type Titanium(IV) Complexes. Angew. Chem. Int. Ed. 2011, 50 (12), 2850-2853
  Albrecht, M.; Isaak, E.; Baumert, M.; Gossen, V.; Raabe, G.; Fröhlich, R.
  
• A Rhodium Complex-linked β-Barrel Protein as a Hybrid Biocatalyst for Phenylacetylene Polymerization. Chem. Commun. 2012, 48 (78), 9756-9758
  Onoda, A.; Fukumoto, K.; Arlt, M.; Bocola, M.; Schwaneberg, U.; Hayashi, T.
  
• Advancement and Application of the Energetic Span Model for DFT Based Catalyst Design – Carboxylation of Arene C–H-Bonds with CO2 and Hydroamination of Ethylene with Ammonia, 04.2012
  Uhe, Andreas
  
• Asymmetric Total Synthesis of Smyrindiol Employing an Organocatalytic Aldol Key Step. Beilstein J. Org. Chem. 2012, 8, 1112-1117
  Enders, D.; Fronert, J.; Bisschops, T.; Boeck, F.
  
• Carboxylation of Arene C–H Bonds with CO2: A DFT-Based Approach to Catalyst Design. Chem. Eur. J. 2012, 18 (1), 170-177
  Uhe, A.; Hölscher, M.; Leitner, W.
  
• Efficient Cyclic Carbonate Synthesis Catalyzed by Zinc Custer Systems Under Mild Conditions. Catal. Sci. Tech. 2012, 2, 509–513
  Yang, Y.; Hayashi, Y.; Fujii, Y.; Nagano, T.; Kita, Y.; Oshima, T.; Okuda, J.; Mashima, K.
  
• Enantioselective Synthesis of α-Alkylidene-γ-Butyrolactones: Intramolecular Rauhut– Currier Reaction Promoted by Acid/Base Organocatalysts. Angew. Chem. Int. Ed. 2012, 51 (22), 5423-5426
  Takizawa, S.; Nguyen, T. M.-N.; Grossmann, A.; Enders, D.; Sasai, H.
  
• Layer-by-Layer Assembly of Partially Sulfonated Isotactic Polystyrene with Poly(vinylamine). Langmuir 2012, 28, 5372– 5378
  Ajiro, H.; Beckerle, K.; Okuda, J.; Akashi, M.
  
• N-Heterocyclic Carbene Catalyzed Domino Reactions. Angew. Chem. Int. Ed. 2012, 51 (2), 314-325
  Grossmann, A.; Enders, D.
  
• Organocatalytic One-Pot Asymmetric Synthesis of 4H,5H-Pyrano[2,3-c]pyrazoles. Org. Lett. 2012, 14 (16), 4254-4257
  Enders, D.; Grossmann, A.; Gieraths, B.; Düzdemir, M.; Merkens, C.
  
• Photoredox Catalysis as an Efficient Tool for the Aerobic Oxidation of Amines and Alcohols: Bioinspired Demethylations and Condensations. ACS Catalysis 2012, 2 (12), 2810- 2815
  Rueping, M.; Vila, C.; Szadkowska, A.; Koenigs, R. M.; Fronert, J.
  
• Ru/Ag- Catalyzed Oxidative Alkenylation of Benzamides and Phenylazoles through Regioselective C–H Bond Cleavage. Chem. Lett. 2012, 41 (2), 151-153
  Hashimoto, Y.; Ortloff, T.; Hirano, K.; Satoh, T.; Bolm, C.; Miura, M.
  
• Supramolecular [M4L4] Tetrahedra Based on Triangular Acylhydrazone Catechol Ligands. Eur. J. Org. Chem. 2012, 2012 (12), 2422-2427
  Albrecht, M.; Shang, Y.; Rhyssen, T.; Stubenrauch, J.; Winkler, H. D. F.; Schalley, C. A.
  
• Synthesis of UDP-Activated Oligosaccharides with Commercial β-Galactosidase from Bacillus circulans under Microwave Irradiation. J. Mol. Catal. B: Enzymatic 2012, 79, 27-34
  Kamerke, C.; Pattky, M.; Huhn, C.; Elling, L.
  
• Synthesis, Characterization, and Lactide Polymerization Activity of Group 4 Metal Complexes Containing Two Bis(phenolate) Ligands. Inorg. Chem. 2012, 51 (10), 5764-5770
  Sauer, A.; Buffet, J.-C.; Spaniol, T. P.; Nagae, H.; Mashima, K.; Okuda, J.
  
• Tuning the Size of Supramolecular M4L4 Tetrahedra by Ligand Connectivity. Dalton Trans. 2012, 41 (31), 9316-9322
  Albrecht, M.; Shang, Y.; Hasui, K.; Gossen, V.; Raabe, G.; Tahara, K.; Tobe, Y.
  
• 2- Methyltetrahydrofuran and Cyclopentylmethylether: Two Green Solvents for Efficient Purification of Membrane Proteins like FhuA. J. Chromatogr. B 2013, 937, 13-17
  Tenne, S.-J.; Kinzel, J.; Arlt, M.; Sibilla, F.; Bocola, M.; Schwaneberg, U.
  
• A Hybrid Ring-Opening Metathesis Polymerization Catalyst Based on an Engineered Variant of the β-Barrel Protein FhuA. Chem. Eur. J. 2013, 19 (41), 13865-13871
  Philippart, F.; Arlt, M.; Gotzen, S.; Tenne, S.-J.; Bocola, M.; Chen, H.-H.; Zhu, L.; Schwaneberg, U.; Okuda, J.
  
• Analysis of Potential Molecular Catalysts for the Hydroamination of Ethylene with Ammonia: A DFT Study with [Ir(PCP)] and [Ir(PSiP)] Complexes. Chem. Eur. J. 2013, 19 (3), 1020-1027
  Uhe, A.; Hölscher, M.; Leitner, W.
  
• Asymmetric Organocatalytic Synthesis of trans-3,4-Disubstituted Isochromanones via an Intramolecular Aldol Reaction. Synthesis 2013, 45 (12), 1708-1712
  Fronert, J.; Bisschops, T.; Cassens-Sasse, E.; Atodiresei, I.; Enders, D.
  
• Asymmetric Synthesis of Pyrroloindolones by N-Heterocyclic Carbene Catalyzed [2+3] Annulation of α-Chloroaldehydes with Nitrovinylindoles. Angew. Chem. Int. Ed. 2013, 52 (51), 13562-13566
  Ni, Q.; Zhang, H.; Grossmann, A.; Loh, C. C. J.; Merkens, C.; Enders, D.
  
• Facile Synthesis of α-Methylidene-γ-butyrolactones: Intramolecular Rauhut–Currier Reaction Promoted by Chiral Acid–base Organocatalysts. Tetrahedron 2013, 69 (3), 1202-1209
  Takizawa, S.; Nguyen, T. M.-N.; Grossmann, A.; Suzuki, M.; Enders, D.; Sasai, H.
  
• Hydrido and Allyl/Hydrido Complexes of Early Lanthanides Supported by an NNNN-Type Macrocyclic Ligand. Eur. J. Inorg. Chem. 2013, 2013 (22-23), 3987-3992
  Martin, D.; Kleemann, J.; Abinet, E.; Spaniol, T. P.; Maron, L.; Okuda, J.
  
• Influence of Initial pH Values on the Lag Phase of Escherichia coli and Bacillus licheniformis Batch Cultures. Chem. Ing. Tech. 2013, 85 (6), 863-871
  Palmen, T. G.; Scheidle, M.; Huber, R.; Kamerke, C.; Wilming, A.; Dittrich, B.; Klee, D.; Büchs, J.
  
• Influence of Microwave Irradiation on β-Galactosidase Catalyzed Transglycosylation Reactions, 02.2013
  Kamerke, Claudia
  
• N-Cyano Sulfoximines: COX Inhibition, Anticancer Activity, Cellular Toxicity, and Mutagenicity. ChemMedChem 2013, 8 (2), 217-220
  Park, S. J.; Baars, H.; Mersmann, S.; Buschmann, H.; Baron, J. M.; Amann, P. M.; Czaja, K.; Hollert, H.; Bluhm, K.; Redelstein, R.; Bolm, C.
  
• N-Heterocyclic Carbene Catalyzed One Pot Asymmetric Synthesis of Bioactive Molecules, 04.2013
  Grossmann, Andre
  
• N-Heterocyclic Carbene Catalyzed Synthesis of Oxime Esters. Org. Biomol. Chem. 2013, 11 (1), 138-141
  Enders, D.; Grossmann, A.; Van Craen, D.
  
• N-Heterocyclic-Carbene-Catalyzed One- Pot Synthesis of Hydroxamic Esters. Chem. Asian. J. 2013, 8 (12), 2965-2969
  Song, X.; Ni, Q.; Grossmann, A.; Enders, D.
  
• Phosphonoethylated Polyglycidols: A Platform for Tunable Enzymatic Grafting Density. Macromolecules 2013, 46 (10), 3708- 3718
  Koehler, J.; Marquardt, F.; Keul, H.; Moeller, M.
  
• Preparation of Microparticles Composed of Amphiphilic Poly(γ-glutamic acid) through Hydrophobic Interactions. Polymer J. 2013, 46, 184-188
  Shima, F.; Schulte, B.; Keul, H.; Moeller, M.; Akashi, M.
  
• Production of Uroporphyrinogen III, Which is the Common Precursor of all Tetrapyrrole Cofactors, from 5-Aminolevulinic Acid by Escherichia Coli Expressing Thermostable Enzymes. Appl. Microbiol. Biot. 2013, 97, 7337–7344
  Hibino, A.; Petri, R.; Büchs, J.; Ohtake, H.
  
• Rhodium Catalyzed Hydroamination of C2H4 with NH3 with Pincer Derived PE(CH2CH2X)P Ligands – Fighting the Energy Span. J. Organomet. Chem. 2013, 748, 13-20
  Hölscher, M.; Uhe, A.; Leitner, W.
  
• Rhodium-Catalyzed C3-Selective Alkenylation of Substituted Thiophene-2-carboxylic Acids and Related Compounds. J. Org. Chem. 2013, 78 (14), 7216-7222
  Iitsuka, T.; Schaal, P.; Hirano, K.; Satoh, T.; Bolm, C.; Miura, M.
  
• Salt-Free Reducing Reagent of Bis(trimethylsilyl)cyclohexadiene Mediates Multielectron Reduction of Chloride Complexes of W(VI) and W(IV). J. Am. Chem. Soc. 2013, 135 (16), 5986-5989
  Tsurugi, H.; Tanahashi, H.; Nishiyama, H.; Fegler, W.; Saito, T.; Sauer, A.; Okuda, J.; Mashima, K
  
• Stereoselective Hierarchical Self-Assembly of Helicates, 12.2013
  Isaak, Elisabeth
  
• Structurally Well- Defined Group 4 Metal Complexes as Initiators for the Ring-opening Polymerization of Lactide Monomers. Dalton Trans. 2013, 42 (25), 9007-9023
  Sauer, A.; Kapelski, A.; Fliedel, C.; Dagorne, S.; Kol, M.; Okuda, J.
  
• Switching the Lactide Polymerization Activity of a Cerium Complex by Redox Reactions. ChemCatChem 2013, 5 (5), 1088-1091
  Sauer, A.; Buffet, J.-C.; Spaniol, T. P.; Nagae, H.; Mashima, K.; Okuda, J.
  
• Synthesis of Nucleotide-Activated Disaccharides with Recombinant β3-Galactosidase C from Bacillus Circulans. J. Mol. Catal. B: Enzymatic 2013, 89, 73-81
  Kamerke, C.; Pattky, M.; Huhn, C.; Elling, L.
  
• Synthesis of Redox Switchable Polymerization Catalysts, 12.2013
  Sauer, Andreas
  
• A Cationic Zinc Hydride Cluster Stabilized by an N-Heterocyclic Carbene: Synthesis, Reactivity, and Hydrosilylation Catalysis. Angew. Chem. Int. Ed. 2014, 53 (48), 13273-13277
  Rit, A.; Zanardi, A.; Spaniol, T. P.; Maron, L.; Okuda, J.
  
• A DFT Study of Ruthenium Pincer Carboxylate Complexes as Potential Catalysts for the Direct Carboxylation of Arenes with CO2 – Meridional Versus Facial Coordination. Dalton Trans. 2014, 43 (29), 11180-11189
  Stoychev, S. D.; Conifer, C. M.; Uhe, A.; Hölscher, M.; Leitner, W.
  
• Chemoenzymatic Syntheses – Hydrolases in Methodology and Application, 07.2014
  Bongen, Patrick
  
• Comparative Analysis of the Adaptive Thermal Properties of Lipolytic Enzymes with Differentem Temperature Origin, 04.2014
  Mandrysch, Agathe
  
• Design of Biohybrid Catalysts for Metathesis Reactions, 10.2014
  Arlt, Marcus
  
• Effective Shear Rates in Shake Flasks. Chem. Eng. Sci. 2014, 118, 102-113
  Giese, H.; Klöckner, W.; Peña, C.; Galindo, E.; Lotter, S.; Wetzel, K.; Meissner, L.; Peter, C. P.; Büchs, J.
  
• Enantioselective Oxidative-coupling of Polycyclic Phenols. Tetrahedron 2014, 70 (9), 1786-1793
  Takizawa, S.; Kodera, J.; Yoshida, Y.; Sako, M.; Breukers, S.; Enders, D.; Sasai, H.
  
• Enzyme–substrate Complex Structures of CYP154C5 Shed Light on its Mode of Highly Selective Steroid Hydroxylation. Acta Cryst. Sec. D 2014, 70 (11), 2875-2889
  Herzog, K.; Bracco, P.; Onoda, A.; Hayashi, T.; Hoffmann, K.; Schallmey, A.
  
• Fed-Batch Operation in Special Microtiter Plates: a New Method for Screening Under Production Conditions. J. Ind. Microbiol. Biot. 2014, 41 (3), 513-525
  Wilming, A.; Bähr, C.; Kamerke, C.; Büchs, J.
  
• Glycosynthase of Bacillus circulans β-1-3-Galactosidase (BgaC). Chem. Ing. Tech. 2014, 86 (9), 1417-1417
  Henze, M.; You, D.-J.; Kamerke, C.; Kanaya, S.; Elling, L.
  
• Phenotyping the Quality of Complex Medium Components by Simple Online-monitored Shake Flask Experiments. Microb. Cell Fact. 2014, 13 (1), 149
  Diederichs, S.; Korona, A.; Staaden, A.; Kroutil, W.; Honda, K.; Ohtake, H.; Büchs, J.
  
• Phosphonoethylated Polyglycidols as Building Blocks for Multifunctional Polyethers – Potential Applications, 05.2014
  Köhler, Jens
  
• Porous Molecular Networks Formed by the Self-assembly of Positively-charged Trigonal Building Blocks at the Liquid/Solid Interfaces. Chem. Commun. 2014, 50, 7683-7685
  Tahara, K.; Abraham, M. L.; Igawa, K.; Katayama, K.; Oppel, I. M.; Tobe, Y.
  
• Rational Design of a Glycosynthase by the Crystal Structure of β-Galactosidase from Bacillus circulans (BgaC) and its Use for the Synthesis of N-Acetyllactosamine type 1 Glycan Structures. J. Biotechnol. 2014, 191, 78-85
  Henze, M.; You, D.-J.; Kamerke, C.; Hoffmann, N.; Angkawidjaja, C.; Ernst, S.; Pietruszka, J.; Kanaya, S.; Elling, L.
  
• Rhodium-catalyzed Intramolecular Dehydrogenative Ary-Aryl Coupling Using Air as Terminal Oxidant. Chem. Lett. 2014, 43 (11), 1782-1784
  Baars, H.; Unoh, Y.; Okada, T.; Hirano, K.; Satoh, T.; Tanaka, K.; Bolm, C.; Miura, M.
  
• Stereocontrol in Dinuclear Triple Lithium-Bridged Titanium(IV) Complexes: Solving Some Stereochemical Mysteries. Chem. Eur. J.2014, 20 (22), 6650-6658
  Albrecht, M.; Isaak, E.; Moha, V.; Raabe, G.; Fröhlich, R.
  
• Synthesis and Characterization of Polyamine-based Cyclophosphazene Hybrid Microspheres. J. Polym. Sci.. A1 2014, 52 (4), 527-536
  Köhler, J.; Kühl, S.; Keul, H.; Möller, M.; Pich, A.
  
• Terpenols as Substituents for the Diastereoselective Formation of Enantiomerically Pure Triple Lithium-Bridged Helicate Type Coordination Compounds. Dalton Trans. 2014, 43 (39), 14636-14643
  Albrecht, M.; Isaak, E.; Shigemitsu, H.; Moha, V.; Raabe, G.; Fröhlich, R.
  
• Transition-Metal-Free Synthesis of Benzimidazoles Mediated by KOH/DMSO. Org. Lett. 2014, 16 (2), 536-539
  Baars, H.; Beyer, A.; Kohlhepp, S. V.; Bolm, C.
  
• A Highly Active Biohybrid Catalyst for Olefin Metathesis in Water: Impact of a Hydrophobic Cavity in a β-Barrel Protein. ACS Catalysis 2015, 5 (12), 7519-7522
  Sauer, D. F.; Himiyama, T.; Tachikawa, K.; Fukumoto, K.; Onoda, A.; Mizohata, E.; Inoue, T.; Bocola, M.; Schwaneberg, U.; Hayashi, T.; Okuda, J.
  
• A Particular Silent Codon Exchange in a Recombinant Gene Greatly Influences Host Cell Metabolic Activity. Microb. Cell Fact. 2015, 14:156
  Rahmen N., Schlupp C. D., Mitsunaga H., Fulton A., Aryani T., Esch L., Schaffrath U., Fukusaki E., Jaeger K. E., Büchs J.
  
• Combination of Glycosyltransferases and a Glycosynthase in Sequential and One-Pot Reactions for the Synthesis of Type 1 and Type 2 N-Acetyllactosamine Oligomers. ChemCatChem 2015, 7 (19), 3131-3139
  Henze, M.; Schmidtke, S.; Hoffmann, N.; Steffens, H.; Pietruszka, J.; Elling, L.
  
• Encapsulation of Enzymes in Silica Nanocapsules Formed by an Amphiphilic Precursor Polymer in Water. J. Mater. Chem. B 2015, 3 (7), 1261-1267
  Zhang, C.; Yan, K.; Hu, C.; Zhao, Y.; Chen, Z.; Zhu, X.; Möller, M.
  
• Enzyme Module Systems for the Synthesis of Uridine 5′-Diphospho-α-D-glucuronic Acid and Non-sulfated Human Natural Killer Cell-1 (HNK-1) Epitope. Adv. Synth. & Catal. 2015, 357 (8), 1751-1762
  Engels, L.; Henze, M.; Hummel, W.; Elling, L.
  
• Extended Dipyrrins as Sensors for Metal Ions, 12.2015
  Guski, Sebastian
  
• High-Level Production of (5S)-Hydroxyhexane-2-one by Two Thermostable Oxidoreductases in a Whole-cell Catalytic Approach. J. Mol. Catal. B: Enzymatic 2015, 121, 37-44
  Diederichs, S.; Linn, K.; Lückgen, J.; Klement, T.; Grosch, J.-H.; Honda, K.; Ohtake, H.; Büchs, J.
  
• Hybrid Ruthenium ROMP Catalysts Based on an Engineered Variant of β-Barrel Protein FhuA ΔCVFtev: Effect of Spacer Length. Chem. Asian. J. 2015, 10 (1), 177-182
  Sauer, D. F.; Bocola, M.; Broglia, C.; Arlt, M.; Zhu, L.-L.; Brocker, M.; Schwaneberg, U.; Okuda, J.
  
• Influence of Nitrogen Source and pH Value on Undesired Poly(γ-Glutamic Acid) Formation of a Protease Producing Bacillus licheniformis Strain. J. Ind. Microbiol. Biot. 2015, 42 (9), 1203-1215
  Meissner, L.; Kauffmann, K.; Wengeler, T.; Mitsunaga, H.; Fukusaki, E.; Büchs, J.
  
• Organocatalytic Asymmetric Syntheses of Dihydrobenzofurans and Isochroman-1-ones, 07.2015
  Fronert, Jeanne Katrin
  
• Phosphine-Catalyzed β,γ-Umpolung Domino Reaction of Allenic Esters: Facile Synthesis of Tetrahydrobenzofuranones Bearing a Chiral Tetrasubstituted Stereogenic Carbon Center. Angew. Chem. Int. Ed. 2015, 54 (51), 15511-15515
  Takizawa, S.; Kishi, K.; Yoshida, Y.; Mader, S.; Arteaga, F. A.; Lee, S.; Hoshino, M.; Rueping, M.; Fujita, M.; Sasai, H.
  
• Rhodium-catalyzed Direct Coupling of Benzothioamides with Alkenes and Alkynes through Directed C–H Bond Cleavage. Chem. Lett. 2015, 44 (8), 1104-1106
  Yokoyama, Y.; Unoh, Y.; Bohmann, R. A.; Satoh, T.; Hirano, K.; Bolm, C.; Miura, M.
  
• Silica Nanoparticles Catalyse the Formation of Silica Nanocapsules in a Surfactant-free Emulsion System. J. Mater. Chem. A 2015, 3 (48), 24428-24436
  Zhao, Y.; Chen, Z.; Zhu, X.; Möller, M.
  
• The Nickel(II)-Catalyzed Direct Benzylation, Allylation, Alkylation, and Methylation of C–H Bonds in Aromatic Amides Containing an 8-Aminoquinoline Moiety as the Directing Group. B. Chem. Soc. Jpn. 2015, 88 (3), 438- 446
  Aihara, Y.; Wuelbern, J.; Chatani, N.
  
• Total Synthesis of Solandelactone I. J. Nat. Prod. 2015, 78, 2782-2790
  C Eichenauer, N.; Tschersich, R.; Pietruszka, J.
  
• Total Synthesis of Solandelactones A and B. Eur. J. Org. Chem.2015, 2015 (25), 5620-5632
  Eichenauer, N. C.; Nordschild, A. C. M.; Bischop, M.; Schumacher, D.; Mackwitz, M. K. W.; Tschersich, R.; Wilhelm, T.; Pietruszka, J.
  
• 1,2-Thiazines: One-Pot Syntheses Utilizing Mono and Diaza Analogs of Sulfones. Chem. Eur. J. 2016, 22 (20), 6783-6786
  Bohmann, R. A.; Unoh, Y.; Miura, M.; Bolm, C.
  
• A Facile One-Step Approach toward Polymer@SiO2 Core–Shell Nanoparticles via a Surfactant-free Miniemulsion Polymerization Technique. Macromolecules 2016, 49 (5), 1552-1562
  Zhao, Y.; Chen, Z.; Zhu, X.; Möller, M.
  
• Alkali Metal Hydridotriphenylborates [(L)M][HBPh3] (M = Li, Na, K): Chemoselective Catalysts for Carbonyl and CO2 Hydroboration. J. Am. Chem. Soc. 2016, 138 (34), 10790-10793
  Mukherjee, D.; Osseili, H.; Spaniol, T. P.; Okuda, J.
  
• Artificial Diels–Alderase Based on the Transmembrane Protein FhuA. Beilstein J. Org. Chem. 2016, 12, 1314-1321
  Osseili, H.; Sauer, D. F.; Beckerle, K.; Arlt, M.; Himiyama, T.; Polen, T.; Onoda, A.; Schwaneberg, U.; Hayashi, T.; Okuda, J.
  
• Asymmetric Brønsted Acid Catalyzed Substitution of Diaryl Methanols with Thiols and Alcohols for the Synthesis of Chiral Thioethers and Ethers. Angew. Chem. Int. Ed. 2016, 55 (15), 4803-4807
  Chatupheeraphat, A.; Liao, H.-H.; Mader, S.; Sako, M.; Sasai, H.; Atodiresei, I.; Rueping, M.
  
• Asymmetric Organocatalytic Synthesis of 4-Aminoisochromanones via a Direct One-pot Intramolecular Mannich Reaction. Synthesis 2016, 48 (24), 4451-4458
  Vetica, F.; Fronert, J.; Puttreddy, R.; Rissanen, K.; Enders, D.
  
• Branched Chain Amino Acids Maintain the Molecular Weight of Poly(γ-Glutamic Acid) of Bacillus licheniformis ATCC 9945 During the Fermentation. J. Biosci. Bioeng. 2016, 122 (4), 400-405
  Mitsunaga, H.; Meissner, L.; Büchs, J.; Fukusaki, E.
  
• Chemoselective Reduction of Tertiary Amides to Amines Catalyzed by Triphenylborane. Angew. Chem. Int. Ed. 2016, 55, 13326–13329
  Mukherjee, D.; Shirase, S.; Mashima, K.; Okuda, J.
  
• Construction of a Hybrid Biocatalyst Containing a Covalently-linked Terpyridine Metal Complex within a Cavity of Aponitrobindin. J. Inorg. Biochem. 2016, 158, 55-61
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• DFT Calculations as Tool in the Rational Design of Molecular Catalysts: Transformations of CO2 - Catalysed by Late Transition Metal Complexes, 10.2016
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• Magnesium Hydridotriphenylborate [Mg(thf)6][HBPh3]2: A Versatile Hydroboration Catalyst. Chem. Commun. 2016, 52, 13155–13158
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• Metabolome Analysis Reveals the Effect of Carbon Catabolite Control on the Poly(γ- Glutamic Acid) Biosynthesis of Bacillus licheniformis ATCC 9945. J. Biosci. Bioeng. 2016, 121 (4), 413-419
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• Metatheases: Artificial Metalloproteins for Olefin Metathesis. Org. Biomol. Chem. 2016, 14 (39), 9174-9183
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• Microwave-assisted Synthesis of Glycoconjugates by Transgalactosylation with Recombinant Thermostable β-Glycosidase from Pyrococcus. Int. J. Mol. Sci. 2016, 17 (2), 210-210
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• Reversible Transformation between Alkylidene, Alkylidyne, and Vinylidene Ligands in High-Valent Bis(phenolate) Tungsten Complexes. Organometallics 2016, 35 (7), 932-935
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• Selective Metal-Free Hydrosilylation of CO2 Catalyzed by Triphenylborane in Highly Polar, Aprotic Solvents. Chem. Eur. J. 2016, 22 (23), 7730-7733
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• Structural Features Determining Thermal Adaptation of Esterases. Protein Eng. Des. Sel. 2016, 29 (2), 65- 76
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• Studies in Base-Mediated Cross-Couplings, Dehydrogenative Couplings and Difluoromethylations, 07.2016
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• The Reactivity of Difluorocarbene with Hydroxylamines: Synthesis of Carbamoyl Fluorides. Adv. Synth. & Catal. 2016, 358 (14), 2293-2299
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• 2-Methyl-2,4-pentanediol (MPD) Boosts as Detergent-substitute the Performance of ß-Barrel Hybrid Catalyst for Phenylacetylene Polymerization. Beilstein J. Org. Chem. 2017, 13, 1498-1506
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• Anionic Extraction for Efficient Recovery of Biobased 2,3- Butanediol—A Platform for Bulk and Fine Chemicals. ChemSusChem 2017, 10 (16), 3252-3259
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• Biohybrid Catalysts for Alkene Metathesis, 09.2017
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• Calcium Hydride Cation [CaH]+ Stabilized by an NNNN-type Macrocyclic Ligand: A Selective Catalyst for Olefin Hydrogenation. Angew. Chem. Int. Ed. 2017, 56 (40), 12367-12371
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• Development of a colourimetric assay for glycosynthases. J. Biotechnol. 2017, 257, 162-170
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• Extended Dipyrrin Ligands: Candidates for Optical Metal Ion Detection Under Competitive Conditions. Chem. Commun.2017, 53 (22), 3213-3215
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• Facile Ring-opening of THF at a Lithium Center Induced by a Pendant Si–H Bond and BPh3. Dalton Trans. 2017, 46 (25), 8017-8021
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• Homogeneous Catalysts for the Copolymerisation of Cyclohexene Oxide with CO2 Based on Multimetallic Complexes of Rare-Earth Metals and Zinc, 09.2017
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• Investigation of Poly(γ-glutamic acid) Production via Online Determination of Viscosity and Oxygen Transfer Rate in Shake Flasks. J. Biol. Eng. 2017, 11 (1), 23
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• Ligand Influence on Carbonyl Hydroboration Catalysis by Alkali Metal Hydridotriphenylborates [(L)M][HBPh3] (M=Li, Na, K). Chem. Eur. J. 2017, 23 (57), 14292-14298
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• Me6TREN- Supported Alkali Metal Hydridotriphenylborates [(L)M][HBPh3] (M = Li, Na, K): Synthesis, Structure, and Reactivity. Organometallics 2017, 36 (16), 3029-3034
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• Mononuclear Alkali Metal Organoperoxides Stabilized by an NNNN-Macrocycle and Short Hydrogen Bonds from ROOH Molecules. Chem. Eur. J. 2017, 23 (68), 17213- 17216
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• On the Way to a Trisanionic {Cu3O2} Core for Oxidase Catalysis: Evidence of an Asymmetric Trinuclear Precursor Stabilized by Perfluoropinacolate Ligands. Chem. Eur. J. 2017, 23 (34), 8212-8224
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• Optische Genregulation in Mikrobioreaktoren. BIOspektrum 2017, 23 (6), 643-645
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• Organocatalysts in Enantioselective Reactions, 12.2017
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• Record Broken: A Copper Peroxide Complex with Enhanced Stability and Faster Hydroxylation Catalysis. Chem. Eur. J. 2017, 23 (50), 12171- 12183
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• Rhodium-catalyzed Synthesis of 1-(Acylamino)isoquinolines through Direct Annulative Coupling of 3-Aryl- 1,2,4-oxadiazoles with Alkynes. Chem. Lett. 2017, 46 (9), 1347-1349
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• Ring-opening of Cyclic Ethers by Aluminum Hydridotriphenylborate. Chem. Commun. 2017, 53 (24), 3493-3496
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• A Helicate-Based Three-State Molecular Switch. Angew. Chem. Int. Ed. 2018, 57 (36), 11817-11820
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• A Whole Cell E. coli Display Platform for Artificial Metalloenzymes: Poly(phenylacetylene) Production with a Rhodium–Nitrobindin Metalloprotein. ACS Catalysis 2018, 8 (3), 2611-2614
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• Acidic Lithium and Aluminum Complexes: Synthesis, Reactivity and Homogeneous Catalysis, 10.2018
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• Cavity Size Engineering of a β-Barrel Protein Generates Efficient Biohybrid Catalysts for Olefin Metathesis. ACS Catalysis 2018, 8 (4), 3358-3364
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• Cyclotrimerization of Phenylacetylene Catalyzed by a Cobalt Half-sandwich Complex Embedded in an Engineered Variant of Transmembrane Protein FhuA. Org. Biomol. Chem. 2018, 16 (30), 5452-5456
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• Deprotonation of a Formato Ligand by a cis-Coordinated Carbyne Ligand within a Bis(phenolate) Tungsten Complex. Dalton Trans. 2018, 47 (38), 13328-13331
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• Designed To React: Terminal Copper Nitrenes and Their Application in Catalytic C−H Aminations. Angew. Chem. Int. Ed. 2018, 57 (29), 9154-9159
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• From Beech Wood to Itaconic Acid: Case Study on Biorefinery Process Integration. Biotechnol. Biofuels 2018, 11 (1), 279
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• Hybrid Nanostructured Particles via Surfactant-free Double Miniemulsion Polymerization. Nature Commun. 2018, 9 (1), 1918
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• Hydrido Complexes of Calcium: A New Family of Molecular Alkaline-Earth-Metal Compounds. Angew. Chem. Int. Ed. 2018, 57 (31), 9590-9602
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• Hypervalent Hydrosilicates Connected to Light Alkali Metal Amides: Synthesis, Structure, and Hydrosilylation Catalysis. Chem. Eur. J. 2018, 24 (51), 13424-13427
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• In Situ Reactive Extraction of Itaconic Acid During Fermentation of Aspergillus terreus. Biochem. Eng. J. 2018, 135, 133-141
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• Inclusion of Phase- Change Materials in Submicron Silica Capsules Using a Surfactant-Free Emulsion Approach. Langmuir 2018, 34 (35), 10397-10406
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• Lanthanide Complexes Supported by a Trizinc Crown Ether as Catalysts for Alternating Copolymerization of Epoxide and CO2: Telomerization Controlled by Carboxylate Anions. Angew. Chem. Int. Ed. 2018, 57 (9), 2492-2496
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• Molecular Hydrides of Divalent Ytterbium Supported by a Macrocyclic Ligand: Synthesis, Structure and Olefin Hydrofunctionalization Catalysis. Chem. Commun. 2018, 54 (80), 11280-11283
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• N-Arylated Sulfoximines as Cross- Coupling Building Blocks. Adv. Synth. & Catal. 2018, 360 (6), 1088-1093
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• Olefin Metathesis Catalysts Embedded in β-Barrel Proteins: Creating Artificial Metalloproteins for Olefin Metathesis. Beilstein J. Org. Chem. 2018, 14, 2861-2871
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• Online Measurement of the Respiratory Activity in Shake Flasks Enables the Identification of Cultivation Phases and Patterns Indicating Recombinant Protein Production in Various Escherichia coli Host Strains. Biotechnol. Progr. 2018, 34 (2), 315-327
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• Oxygen Atom Transfer Reactions with Molybdenum Cofactor Model Complexes That Contain a Tetradentate OSSO- Type Bis(phenolato) Ligand. Organometallics 2018, 37 (23), 4336-4340
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• Protein Engineering for Biohybrid Catalysis, 11.2018
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• Pyridine-N-oxide Based Ligands - Structures and Coordination Compounds,10.2018
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• Tyrosinases in Organic Chemistry: A Versatile Tool for the α-Arylation of β-Dicarbonyl Compounds. Eur. J. Org. Chem. 2018, 2018 (15), 1789-1796
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• 3D Heterocycles from Sulfonimidamides by Sequential C−H Bond Alkenylation/Aza-Michael Cyclization. Chem. Eur. J. 2019, 25 (23), 5889-5892
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• Anchor Peptide-mediated Surface Immobilization of a Grubbs-Hoveyda-Type Catalyst for Ring-opening Metathesis Polymerization. Bioconjugate Chem. 2019, 30 (3), 714-720
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• Biohybrid Catalysts for Sequential One-pot Reactions Based on an Engineered Transmembrane Protein. Catal. Sci. Technol., 2019, 9, 942-946
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• Cation Controlled Formation and Interconversion of fac/fac and mer/mer Stereoisomers of a Triplestranded Helicate. Angew. Chem. Int. Ed. 2019
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• Cationic Magnesium Hydride [MgH]+ Stabilized by an NNNN-type Macrocycle. Chem. Commun. 2019, 55 (22), 3199-3202
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• Development of New Enantioselective Reactions with Phosphor-Broensted-Acids, 08.2019
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• Dual Oxidase/Oxygenase Reactivity and Resonance Raman Spectra of {Cu3O2} Moiety with Perfluoro-t-butoxide Ligands. Dalton Trans. 2019, 48 (20), 6899-6909
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• Formation of Monodisperse Polymer@SiO2 Core–Shell Nanoparticles via Polymerization in Emulsions Stabilized by Amphiphilic Silica Precursor Polymers: HLB Dictates the Reaction Mechanism and Particle Size. Macromolecules 2019, 52 (15), 5670-5678
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• Hydridoaluminates and Hydridoborates of Lithium Stabilized by a Cyclen-derived NNNN-Type Macrocyclic Ligand. J. Organomet. Chem. 2019, 894, 39-42
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• Integrated in-situ Product Removal Process Concept for Itaconic Acid by Reactive Extraction, pH-Shift Back Extraction and Purification by pH-Shift Crystallization. Sep. Purif. Technol. 2019, 215, 463-472
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• Molecular Magnesium Hydrides and Bimetallic Lithium Hydrido Aluminates, 01.2019
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• Mono- and Tetranuclear Complexes Featuring (OSSO)- or Tris(ONNO)-Type Ligands for Selective Catalysis, 09.2019
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• One-pot Two-Step Chemoenzymatic Cascade for the Synthesis of a Bis-benzofuran Derivative. Eur. J. Org. Chem. 2019
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• Oxidoreductases: Providing Key Intermediates for Drug and Natural Product Synthesis, 02.2019
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• Photoredox/Rhodium Catalysis in C– H Activation for the Synthesis of Nitrogen Containing heterocycles. Org. Chem. Front. 2019, 6, 2319-2323
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• Regioselective Syntheses of 1,2-Benzothiazine 1-Imines by Rhodium-Catalyzed Annulation Reactions of Sulfondiimines. Adv. Synth. & Catal. 2019
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• Schwaneberg, U., Towards the Evolution of Artificial Metalloenzymes—A Protein Engineer's Perspective. Angew. Chem. Int. Ed. 2019, 58 (14), 4454-4464
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• Shake Flask Methodology for Assessing the Influence of the Maximum Oxygen Transfer Capacity on 2,3-Butanediol Production. Microb. Cell Fact. 2019, 18 (1), 78
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• Tailor-made polyγ-glutamic acid production. Metabolic Engineering 2019
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• Titanium Carbene Complexes Stabilized by Alkali Metal Amides. Angew. Chem. Int. Ed. 2019, 58 (6), 1833-1837
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• Transition Metal-Catalyzed Syntheses of Heterocycles and Sulfur-Containing Molecules, 07.2019
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• Tyrosinase Model Systems and Biohybrid Conjugates with Copper Bis(pyrazolyl)methane Complexes, 02.2019
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