GRK 1628:  Selectivity in Chemo- and Biokatalysis

• Subject Area: Molecular Chemistry
• Term: from 2010 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 135945478

• Final Report Year: 2019

Final Report Abstract

Selectivity in catalyzed transformations of substrates is an essential feature for the sustainable (“green”) production of chemicals. This becomes particularly critical when feedstocks for raw materials will shift from conventional fossil sources (coal, petroleum) to biorenewable sources and possibly to carbon dioxide. The understanding and rational design of catalysts – both chemical and biological – requires a venture into new systems. The International Research Training Program “Selectivity in Chemo- and Biocatalysis (SeleCa)” was established at RWTH Aachen University in 2010. It aims at the understanding of efficient and selective catalytic reactions on the molecular level of both homogeneous and biological (enzymatic) catalysts. Simultaneously, the Japanese German Graduate Externship Program on “Environmentally Benign Bio- and Chemical Processes“ funded by the Japan Society for the Promotion of Science (JSPS) was established at Osaka University’s Department of Engineering and Department of Engineering Science. Interdisciplinary and transnational research in areas of both chemical and enzymatic catalysis has been performed in a unique international collaborative approach. The cooperation involved twelve groups from RWTH Aachen University along with two associated groups each from Research Centre Jülich and eleven groups from Osaka University. Graduate students both of chemistry and biotechnology were involved in joint projects including: metal catalysis (selective catalytic functionalization of aromatic substrates; efficient and selective formation of carbon-carbon and carbon-heteroatom bonds; bimetallic redox-active biomimetic catalysts for selective C-H bond functionalization and switchable polymerization; development of novel bifunctional organocatalysts), supramolecular catalysis (selective hydrogenation catalysts based on molecular recognition), biocatalysis (identification, biochemical, and functional characterization of novel biocatalysts; new glycosynthases; selective production and analysis of poly(γ-glutamic acid) with distinct molecular weight distribution and composition), biohybrid catalysis (hybrid biocatalysts for selective polymerizations; non-heme protein models for biomimetic oxidation reactions; multifunctional polyethers through chemical and enzymatic catalysis). Despite the great geographical distance, the scientific exchange activity and interactions were generally intense, amicable, and fruitful throughout the entire funding period. As a particularly successful collaboration between chemistry and biotechnology as well as between Aachen/Jülich and Osaka, the area of biohybrid catalysts or so-called artificial metalloenzymes and whole-cell catalysts contributed to a timely and highly competitive research field. Over the past nine years, joint symposia with eminent international guest speakers, including Nobel laureates, were annually held both in Aachen and Osaka (in total 18). The graduate students were encouraged to organize and execute these formal scientific events in a responsible manner. In addition, graduate students completed mutual research stays of up to one year at both universities and participated in lecture courses, regular research seminars, specialized workshops and excursions to companies. Additional soft skills, including safeguarding good scientific practice, gender issues, Japanese language/culture, and project management were acquired. Despite the difference in regulations in three separate faculties, joint doctoral defense examinations were also realized both in Aachen and Osaka. This has ensured direct comparison of the scientific standard of dissertations in the partner institutions and triggered discussions on the nature of the doctoral examination within the RWTH faculty. In total, 46 doctoral dissertations were successfully concluded, and 218 papers were published, in addition to >300 poster and oral presentations at national and international conferences. It is believed that at the end of this nine years’ program, substantial internationalization has been realized by educating graduate students who are knowledgeable in both chemo- and biocatalysis and cross-cultural experience. Graduates of this IRTG are well prepared for employment in a more interdisciplinary and rapidly globalizing labor market.

Publications

• C–H Bond Activation of N-Heterocyclic Carbene IMes by Rare-earth Metal Alkyl Complexes. J. Organomet. Chem. 2010, 695 (25), 2794-2797
  Fegler, W.; Saito, T.; Mashima, K.; Spaniol, T. P.; Okuda, J.
  (See online at https://doi.org/10.1016/j.jorganchem.2010.08.021)
• N-Heterocyclic Carbene Catalysed Asymmetric Cross-benzoin Reactions of Heteroaromatic Aldehydes with trifluoromethyl ketones. Chem. Commun. 2010, 46 (34), 6282-6284
  Enders, D.; Grossmann, A.; Fronert, J.; Raabe, G.
  (See online at https://doi.org/10.1039/c0cc02013c)
• Copper- Catalyzed Direct Sulfoximination of Azoles and Polyfluoroarenes under Ambient Conditions. Org. Lett. 2011, 13, 359–361
  Miyasaka, M.; Hirano, K.; Satoh, T.; Kowalczyk, R.; Bolm, C.; Miura, M.
  (See online at https://doi.org/10.1021/ol102844q)
• Design and Synthesis of Supramolecular Tetrahedra, 12.2011
  Shang, Yuli
  
• Dual Secondary Amine/N- Heterocyclic Carbene Catalysis in the Asymmetric Michael/Cross-Benzoin Cascade Reaction of β-Oxo Sulfones with Enals. Eur. J. Org. Chem. 2011, 2011 (23), 4298-4301
  Enders, D.; Grossmann, A.; Huang, H.; Raabe, G.
  (See online at https://doi.org/10.1002/ejoc.201100690)
• Post-polymerization Functionalization of Linear Polyglycidol with Diethyl Vinylphosphonate. Chem. Commun. 2011, 47 (28), 8148-8150
  Köhler, J.; Keul, H.; Möller, M.
  (See online at https://doi.org/10.1039/c1cc12484f)
• “Induced Fit” in Chiral Recognition: Epimerization upon Dimerization in the Hierarchical Self-Assembly of Helicate-type Titanium(IV) Complexes. Angew. Chem. Int. Ed. 2011, 50 (12), 2850-2853
  Albrecht, M.; Isaak, E.; Baumert, M.; Gossen, V.; Raabe, G.; Fröhlich, R.
  (See online at https://doi.org/10.1002/anie.201006448)
• A Rhodium Complex-linked β-Barrel Protein as a Hybrid Biocatalyst for Phenylacetylene Polymerization. Chem. Commun. 2012, 48 (78), 9756-9758
  Onoda, A.; Fukumoto, K.; Arlt, M.; Bocola, M.; Schwaneberg, U.; Hayashi, T.
  (See online at https://doi.org/10.1039/c2cc35165j)
• Advancement and Application of the Energetic Span Model for DFT Based Catalyst Design – Carboxylation of Arene C–H-Bonds with CO2 and Hydroamination of Ethylene with Ammonia, 04.2012
  Uhe, Andreas
  
• Asymmetric Total Synthesis of Smyrindiol Employing an Organocatalytic Aldol Key Step. Beilstein J. Org. Chem. 2012, 8, 1112-1117
  Enders, D.; Fronert, J.; Bisschops, T.; Boeck, F.
  (See online at https://doi.org/10.3762/bjoc.8.123)
• Carboxylation of Arene C–H Bonds with CO2: A DFT-Based Approach to Catalyst Design. Chem. Eur. J. 2012, 18 (1), 170-177
  Uhe, A.; Hölscher, M.; Leitner, W.
  (See online at https://doi.org/10.1002/chem.201102785)
• Efficient Cyclic Carbonate Synthesis Catalyzed by Zinc Custer Systems Under Mild Conditions. Catal. Sci. Tech. 2012, 2, 509–513
  Yang, Y.; Hayashi, Y.; Fujii, Y.; Nagano, T.; Kita, Y.; Oshima, T.; Okuda, J.; Mashima, K.
  (See online at https://doi.org/10.1039/c1cy00404b)
• Enantioselective Synthesis of α-Alkylidene-γ-Butyrolactones: Intramolecular Rauhut– Currier Reaction Promoted by Acid/Base Organocatalysts. Angew. Chem. Int. Ed. 2012, 51 (22), 5423-5426
  Takizawa, S.; Nguyen, T. M.-N.; Grossmann, A.; Enders, D.; Sasai, H.
  (See online at https://doi.org/10.1002/anie.201201542)
• Layer-by-Layer Assembly of Partially Sulfonated Isotactic Polystyrene with Poly(vinylamine). Langmuir 2012, 28, 5372– 5378
  Ajiro, H.; Beckerle, K.; Okuda, J.; Akashi, M.
  (See online at https://doi.org/10.1021/la300627q)
• N-Heterocyclic Carbene Catalyzed Domino Reactions. Angew. Chem. Int. Ed. 2012, 51 (2), 314-325
  Grossmann, A.; Enders, D.
  (See online at https://doi.org/10.1002/anie.201105415)
• Organocatalytic One-Pot Asymmetric Synthesis of 4H,5H-Pyrano[2,3-c]pyrazoles. Org. Lett. 2012, 14 (16), 4254-4257
  Enders, D.; Grossmann, A.; Gieraths, B.; Düzdemir, M.; Merkens, C.
  (See online at https://doi.org/10.1021/ol301983f)
• Photoredox Catalysis as an Efficient Tool for the Aerobic Oxidation of Amines and Alcohols: Bioinspired Demethylations and Condensations. ACS Catalysis 2012, 2 (12), 2810- 2815
  Rueping, M.; Vila, C.; Szadkowska, A.; Koenigs, R. M.; Fronert, J.
  (See online at https://doi.org/10.1021/cs300604k)
• Ru/Ag- Catalyzed Oxidative Alkenylation of Benzamides and Phenylazoles through Regioselective C–H Bond Cleavage. Chem. Lett. 2012, 41 (2), 151-153
  Hashimoto, Y.; Ortloff, T.; Hirano, K.; Satoh, T.; Bolm, C.; Miura, M.
  (See online at https://doi.org/10.1246/cl.2012.151)
• Supramolecular [M4L4] Tetrahedra Based on Triangular Acylhydrazone Catechol Ligands. Eur. J. Org. Chem. 2012, 2012 (12), 2422-2427
  Albrecht, M.; Shang, Y.; Rhyssen, T.; Stubenrauch, J.; Winkler, H. D. F.; Schalley, C. A.
  (See online at https://doi.org/10.1002/ejoc.201101725)
• Synthesis of UDP-Activated Oligosaccharides with Commercial β-Galactosidase from Bacillus circulans under Microwave Irradiation. J. Mol. Catal. B: Enzymatic 2012, 79, 27-34
  Kamerke, C.; Pattky, M.; Huhn, C.; Elling, L.
  (See online at https://doi.org/10.1016/j.molcatb.2012.04.003)
• Synthesis, Characterization, and Lactide Polymerization Activity of Group 4 Metal Complexes Containing Two Bis(phenolate) Ligands. Inorg. Chem. 2012, 51 (10), 5764-5770
  Sauer, A.; Buffet, J.-C.; Spaniol, T. P.; Nagae, H.; Mashima, K.; Okuda, J.
  (See online at https://doi.org/10.1021/ic300271h)
• Tuning the Size of Supramolecular M4L4 Tetrahedra by Ligand Connectivity. Dalton Trans. 2012, 41 (31), 9316-9322
  Albrecht, M.; Shang, Y.; Hasui, K.; Gossen, V.; Raabe, G.; Tahara, K.; Tobe, Y.
  (See online at https://doi.org/10.1039/c2dt30888f)
• 2- Methyltetrahydrofuran and Cyclopentylmethylether: Two Green Solvents for Efficient Purification of Membrane Proteins like FhuA. J. Chromatogr. B 2013, 937, 13-17
  Tenne, S.-J.; Kinzel, J.; Arlt, M.; Sibilla, F.; Bocola, M.; Schwaneberg, U.
  (See online at https://doi.org/10.1016/j.jchromb.2013.07.021)
• A Hybrid Ring-Opening Metathesis Polymerization Catalyst Based on an Engineered Variant of the β-Barrel Protein FhuA. Chem. Eur. J. 2013, 19 (41), 13865-13871
  Philippart, F.; Arlt, M.; Gotzen, S.; Tenne, S.-J.; Bocola, M.; Chen, H.-H.; Zhu, L.; Schwaneberg, U.; Okuda, J.
  (See online at https://doi.org/10.1002/chem.201301515)
• Analysis of Potential Molecular Catalysts for the Hydroamination of Ethylene with Ammonia: A DFT Study with [Ir(PCP)] and [Ir(PSiP)] Complexes. Chem. Eur. J. 2013, 19 (3), 1020-1027
  Uhe, A.; Hölscher, M.; Leitner, W.
  (See online at https://doi.org/10.1002/chem.201202185)
• Asymmetric Organocatalytic Synthesis of trans-3,4-Disubstituted Isochromanones via an Intramolecular Aldol Reaction. Synthesis 2013, 45 (12), 1708-1712
  Fronert, J.; Bisschops, T.; Cassens-Sasse, E.; Atodiresei, I.; Enders, D.
  (See online at https://doi.org/10.1055/s-0033-1338742)
• Asymmetric Synthesis of Pyrroloindolones by N-Heterocyclic Carbene Catalyzed [2+3] Annulation of α-Chloroaldehydes with Nitrovinylindoles. Angew. Chem. Int. Ed. 2013, 52 (51), 13562-13566
  Ni, Q.; Zhang, H.; Grossmann, A.; Loh, C. C. J.; Merkens, C.; Enders, D.
  (See online at https://doi.org/10.1002/anie.201305957)
• Facile Synthesis of α-Methylidene-γ-butyrolactones: Intramolecular Rauhut–Currier Reaction Promoted by Chiral Acid–base Organocatalysts. Tetrahedron 2013, 69 (3), 1202-1209
  Takizawa, S.; Nguyen, T. M.-N.; Grossmann, A.; Suzuki, M.; Enders, D.; Sasai, H.
  (See online at https://doi.org/10.1016/j.tet.2012.11.046)
• Hydrido and Allyl/Hydrido Complexes of Early Lanthanides Supported by an NNNN-Type Macrocyclic Ligand. Eur. J. Inorg. Chem. 2013, 2013 (22-23), 3987-3992
  Martin, D.; Kleemann, J.; Abinet, E.; Spaniol, T. P.; Maron, L.; Okuda, J.
  (See online at https://doi.org/10.1002/ejic.201300167)
• Influence of Initial pH Values on the Lag Phase of Escherichia coli and Bacillus licheniformis Batch Cultures. Chem. Ing. Tech. 2013, 85 (6), 863-871
  Palmen, T. G.; Scheidle, M.; Huber, R.; Kamerke, C.; Wilming, A.; Dittrich, B.; Klee, D.; Büchs, J.
  (See online at https://doi.org/10.1002/cite.201200200)
• Influence of Microwave Irradiation on β-Galactosidase Catalyzed Transglycosylation Reactions, 02.2013
  Kamerke, Claudia
  
• N-Cyano Sulfoximines: COX Inhibition, Anticancer Activity, Cellular Toxicity, and Mutagenicity. ChemMedChem 2013, 8 (2), 217-220
  Park, S. J.; Baars, H.; Mersmann, S.; Buschmann, H.; Baron, J. M.; Amann, P. M.; Czaja, K.; Hollert, H.; Bluhm, K.; Redelstein, R.; Bolm, C.
  (See online at https://doi.org/10.1002/cmdc.201200403)
• N-Heterocyclic Carbene Catalyzed One Pot Asymmetric Synthesis of Bioactive Molecules, 04.2013
  Grossmann, Andre
  
• N-Heterocyclic Carbene Catalyzed Synthesis of Oxime Esters. Org. Biomol. Chem. 2013, 11 (1), 138-141
  Enders, D.; Grossmann, A.; Van Craen, D.
  (See online at https://doi.org/10.1039/c2ob26974k)
• N-Heterocyclic-Carbene-Catalyzed One- Pot Synthesis of Hydroxamic Esters. Chem. Asian. J. 2013, 8 (12), 2965-2969
  Song, X.; Ni, Q.; Grossmann, A.; Enders, D.
  (See online at https://doi.org/10.1002/asia.201300938)
• Phosphonoethylated Polyglycidols: A Platform for Tunable Enzymatic Grafting Density. Macromolecules 2013, 46 (10), 3708- 3718
  Koehler, J.; Marquardt, F.; Keul, H.; Moeller, M.
  (See online at https://doi.org/10.1021/ma400255n)
• Preparation of Microparticles Composed of Amphiphilic Poly(γ-glutamic acid) through Hydrophobic Interactions. Polymer J. 2013, 46, 184-188
  Shima, F.; Schulte, B.; Keul, H.; Moeller, M.; Akashi, M.
  (See online at https://doi.org/10.1038/pj.2013.74)
• Production of Uroporphyrinogen III, Which is the Common Precursor of all Tetrapyrrole Cofactors, from 5-Aminolevulinic Acid by Escherichia Coli Expressing Thermostable Enzymes. Appl. Microbiol. Biot. 2013, 97, 7337–7344
  Hibino, A.; Petri, R.; Büchs, J.; Ohtake, H.
  (See online at https://doi.org/10.1007/s00253-013-4904-z)
• Rhodium Catalyzed Hydroamination of C2H4 with NH3 with Pincer Derived PE(CH2CH2X)P Ligands – Fighting the Energy Span. J. Organomet. Chem. 2013, 748, 13-20
  Hölscher, M.; Uhe, A.; Leitner, W.
  (See online at https://doi.org/10.1016/j.jorganchem.2013.03.004)
• Rhodium-Catalyzed C3-Selective Alkenylation of Substituted Thiophene-2-carboxylic Acids and Related Compounds. J. Org. Chem. 2013, 78 (14), 7216-7222
  Iitsuka, T.; Schaal, P.; Hirano, K.; Satoh, T.; Bolm, C.; Miura, M.
  (See online at https://doi.org/10.1021/jo4011969)
• Salt-Free Reducing Reagent of Bis(trimethylsilyl)cyclohexadiene Mediates Multielectron Reduction of Chloride Complexes of W(VI) and W(IV). J. Am. Chem. Soc. 2013, 135 (16), 5986-5989
  Tsurugi, H.; Tanahashi, H.; Nishiyama, H.; Fegler, W.; Saito, T.; Sauer, A.; Okuda, J.; Mashima, K
  (See online at https://doi.org/10.1021/ja401589a)
• Stereoselective Hierarchical Self-Assembly of Helicates, 12.2013
  Isaak, Elisabeth
  
• Structurally Well- Defined Group 4 Metal Complexes as Initiators for the Ring-opening Polymerization of Lactide Monomers. Dalton Trans. 2013, 42 (25), 9007-9023
  Sauer, A.; Kapelski, A.; Fliedel, C.; Dagorne, S.; Kol, M.; Okuda, J.
  (See online at https://doi.org/10.1039/c3dt00010a)
• Switching the Lactide Polymerization Activity of a Cerium Complex by Redox Reactions. ChemCatChem 2013, 5 (5), 1088-1091
  Sauer, A.; Buffet, J.-C.; Spaniol, T. P.; Nagae, H.; Mashima, K.; Okuda, J.
  (See online at https://doi.org/10.1002/cctc.201200705)
• Synthesis of Nucleotide-Activated Disaccharides with Recombinant β3-Galactosidase C from Bacillus Circulans. J. Mol. Catal. B: Enzymatic 2013, 89, 73-81
  Kamerke, C.; Pattky, M.; Huhn, C.; Elling, L.
  (See online at https://doi.org/10.1016/j.molcatb.2012.12.014)
• Synthesis of Redox Switchable Polymerization Catalysts, 12.2013
  Sauer, Andreas
  
• A Cationic Zinc Hydride Cluster Stabilized by an N-Heterocyclic Carbene: Synthesis, Reactivity, and Hydrosilylation Catalysis. Angew. Chem. Int. Ed. 2014, 53 (48), 13273-13277
  Rit, A.; Zanardi, A.; Spaniol, T. P.; Maron, L.; Okuda, J.
  (See online at https://doi.org/10.1002/anie.201408346)
• A DFT Study of Ruthenium Pincer Carboxylate Complexes as Potential Catalysts for the Direct Carboxylation of Arenes with CO2 – Meridional Versus Facial Coordination. Dalton Trans. 2014, 43 (29), 11180-11189
  Stoychev, S. D.; Conifer, C. M.; Uhe, A.; Hölscher, M.; Leitner, W.
  (See online at https://doi.org/10.1039/c4dt00294f)
• Chemoenzymatic Syntheses – Hydrolases in Methodology and Application, 07.2014
  Bongen, Patrick
  
• Comparative Analysis of the Adaptive Thermal Properties of Lipolytic Enzymes with Differentem Temperature Origin, 04.2014
  Mandrysch, Agathe
  
• Design of Biohybrid Catalysts for Metathesis Reactions, 10.2014
  Arlt, Marcus
  
• Effective Shear Rates in Shake Flasks. Chem. Eng. Sci. 2014, 118, 102-113
  Giese, H.; Klöckner, W.; Peña, C.; Galindo, E.; Lotter, S.; Wetzel, K.; Meissner, L.; Peter, C. P.; Büchs, J.
  (See online at https://doi.org/10.1016/j.ces.2014.07.037)
• Enantioselective Oxidative-coupling of Polycyclic Phenols. Tetrahedron 2014, 70 (9), 1786-1793
  Takizawa, S.; Kodera, J.; Yoshida, Y.; Sako, M.; Breukers, S.; Enders, D.; Sasai, H.
  (See online at https://doi.org/10.1016/j.tet.2014.01.017)
• Enzyme–substrate Complex Structures of CYP154C5 Shed Light on its Mode of Highly Selective Steroid Hydroxylation. Acta Cryst. Sec. D 2014, 70 (11), 2875-2889
  Herzog, K.; Bracco, P.; Onoda, A.; Hayashi, T.; Hoffmann, K.; Schallmey, A.
  (See online at https://doi.org/10.1107/s1399004714019129)
• Fed-Batch Operation in Special Microtiter Plates: a New Method for Screening Under Production Conditions. J. Ind. Microbiol. Biot. 2014, 41 (3), 513-525
  Wilming, A.; Bähr, C.; Kamerke, C.; Büchs, J.
  (See online at https://doi.org/10.1007/s10295-013-1396-x)
• Glycosynthase of Bacillus circulans β-1-3-Galactosidase (BgaC). Chem. Ing. Tech. 2014, 86 (9), 1417-1417
  Henze, M.; You, D.-J.; Kamerke, C.; Kanaya, S.; Elling, L.
  (See online at https://doi.org/10.1002/cite.201450479)
• Phenotyping the Quality of Complex Medium Components by Simple Online-monitored Shake Flask Experiments. Microb. Cell Fact. 2014, 13 (1), 149
  Diederichs, S.; Korona, A.; Staaden, A.; Kroutil, W.; Honda, K.; Ohtake, H.; Büchs, J.
  (See online at https://doi.org/10.1186/s12934-014-0149-5)
• Phosphonoethylated Polyglycidols as Building Blocks for Multifunctional Polyethers – Potential Applications, 05.2014
  Köhler, Jens
  
• Porous Molecular Networks Formed by the Self-assembly of Positively-charged Trigonal Building Blocks at the Liquid/Solid Interfaces. Chem. Commun. 2014, 50, 7683-7685
  Tahara, K.; Abraham, M. L.; Igawa, K.; Katayama, K.; Oppel, I. M.; Tobe, Y.
  (See online at https://doi.org/10.1039/c4cc01576b)
• Rational Design of a Glycosynthase by the Crystal Structure of β-Galactosidase from Bacillus circulans (BgaC) and its Use for the Synthesis of N-Acetyllactosamine type 1 Glycan Structures. J. Biotechnol. 2014, 191, 78-85
  Henze, M.; You, D.-J.; Kamerke, C.; Hoffmann, N.; Angkawidjaja, C.; Ernst, S.; Pietruszka, J.; Kanaya, S.; Elling, L.
  (See online at https://doi.org/10.1016/j.jbiotec.2014.07.003)
• Rhodium-catalyzed Intramolecular Dehydrogenative Ary-Aryl Coupling Using Air as Terminal Oxidant. Chem. Lett. 2014, 43 (11), 1782-1784
  Baars, H.; Unoh, Y.; Okada, T.; Hirano, K.; Satoh, T.; Tanaka, K.; Bolm, C.; Miura, M.
  (See online at https://doi.org/10.1246/cl.140690)
• Stereocontrol in Dinuclear Triple Lithium-Bridged Titanium(IV) Complexes: Solving Some Stereochemical Mysteries. Chem. Eur. J.2014, 20 (22), 6650-6658
  Albrecht, M.; Isaak, E.; Moha, V.; Raabe, G.; Fröhlich, R.
  (See online at https://doi.org/10.1002/chem.201402370)
• Synthesis and Characterization of Polyamine-based Cyclophosphazene Hybrid Microspheres. J. Polym. Sci.. A1 2014, 52 (4), 527-536
  Köhler, J.; Kühl, S.; Keul, H.; Möller, M.; Pich, A.
  (See online at https://doi.org/10.1002/pola.27028)
• Terpenols as Substituents for the Diastereoselective Formation of Enantiomerically Pure Triple Lithium-Bridged Helicate Type Coordination Compounds. Dalton Trans. 2014, 43 (39), 14636-14643
  Albrecht, M.; Isaak, E.; Shigemitsu, H.; Moha, V.; Raabe, G.; Fröhlich, R.
  (See online at https://doi.org/10.1039/c4dt01553c)
• Transition-Metal-Free Synthesis of Benzimidazoles Mediated by KOH/DMSO. Org. Lett. 2014, 16 (2), 536-539
  Baars, H.; Beyer, A.; Kohlhepp, S. V.; Bolm, C.
  (See online at https://doi.org/10.1021/ol403414v)
• A Highly Active Biohybrid Catalyst for Olefin Metathesis in Water: Impact of a Hydrophobic Cavity in a β-Barrel Protein. ACS Catalysis 2015, 5 (12), 7519-7522
  Sauer, D. F.; Himiyama, T.; Tachikawa, K.; Fukumoto, K.; Onoda, A.; Mizohata, E.; Inoue, T.; Bocola, M.; Schwaneberg, U.; Hayashi, T.; Okuda, J.
  (See online at https://doi.org/10.1021/acscatal.5b01792)
• A Particular Silent Codon Exchange in a Recombinant Gene Greatly Influences Host Cell Metabolic Activity. Microb. Cell Fact. 2015, 14:156
  Rahmen N., Schlupp C. D., Mitsunaga H., Fulton A., Aryani T., Esch L., Schaffrath U., Fukusaki E., Jaeger K. E., Büchs J.
  (See online at https://doi.org/10.1186/s12934-015-0348-8)
• Combination of Glycosyltransferases and a Glycosynthase in Sequential and One-Pot Reactions for the Synthesis of Type 1 and Type 2 N-Acetyllactosamine Oligomers. ChemCatChem 2015, 7 (19), 3131-3139
  Henze, M.; Schmidtke, S.; Hoffmann, N.; Steffens, H.; Pietruszka, J.; Elling, L.
  (See online at https://doi.org/10.1002/cctc.201500645)
• Encapsulation of Enzymes in Silica Nanocapsules Formed by an Amphiphilic Precursor Polymer in Water. J. Mater. Chem. B 2015, 3 (7), 1261-1267
  Zhang, C.; Yan, K.; Hu, C.; Zhao, Y.; Chen, Z.; Zhu, X.; Möller, M.
  (See online at https://doi.org/10.1039/c4tb01701c)
• Enzyme Module Systems for the Synthesis of Uridine 5′-Diphospho-α-D-glucuronic Acid and Non-sulfated Human Natural Killer Cell-1 (HNK-1) Epitope. Adv. Synth. & Catal. 2015, 357 (8), 1751-1762
  Engels, L.; Henze, M.; Hummel, W.; Elling, L.
  (See online at https://doi.org/10.1002/adsc.201500180)
• Extended Dipyrrins as Sensors for Metal Ions, 12.2015
  Guski, Sebastian
  
• High-Level Production of (5S)-Hydroxyhexane-2-one by Two Thermostable Oxidoreductases in a Whole-cell Catalytic Approach. J. Mol. Catal. B: Enzymatic 2015, 121, 37-44
  Diederichs, S.; Linn, K.; Lückgen, J.; Klement, T.; Grosch, J.-H.; Honda, K.; Ohtake, H.; Büchs, J.
  (See online at https://doi.org/10.1016/j.molcatb.2015.08.001)
• Hybrid Ruthenium ROMP Catalysts Based on an Engineered Variant of β-Barrel Protein FhuA ΔCVFtev: Effect of Spacer Length. Chem. Asian. J. 2015, 10 (1), 177-182
  Sauer, D. F.; Bocola, M.; Broglia, C.; Arlt, M.; Zhu, L.-L.; Brocker, M.; Schwaneberg, U.; Okuda, J.
  (See online at https://doi.org/10.1002/asia.201403005)
• Influence of Nitrogen Source and pH Value on Undesired Poly(γ-Glutamic Acid) Formation of a Protease Producing Bacillus licheniformis Strain. J. Ind. Microbiol. Biot. 2015, 42 (9), 1203-1215
  Meissner, L.; Kauffmann, K.; Wengeler, T.; Mitsunaga, H.; Fukusaki, E.; Büchs, J.
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• Formation of Monodisperse Polymer@SiO2 Core–Shell Nanoparticles via Polymerization in Emulsions Stabilized by Amphiphilic Silica Precursor Polymers: HLB Dictates the Reaction Mechanism and Particle Size. Macromolecules 2019, 52 (15), 5670-5678
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• Hydridoaluminates and Hydridoborates of Lithium Stabilized by a Cyclen-derived NNNN-Type Macrocyclic Ligand. J. Organomet. Chem. 2019, 894, 39-42
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• Integrated in-situ Product Removal Process Concept for Itaconic Acid by Reactive Extraction, pH-Shift Back Extraction and Purification by pH-Shift Crystallization. Sep. Purif. Technol. 2019, 215, 463-472
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• Molecular Magnesium Hydrides and Bimetallic Lithium Hydrido Aluminates, 01.2019
  Lemmerz, Lara Elisa
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• Mono- and Tetranuclear Complexes Featuring (OSSO)- or Tris(ONNO)-Type Ligands for Selective Catalysis, 09.2019
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• One-pot Two-Step Chemoenzymatic Cascade for the Synthesis of a Bis-benzofuran Derivative. Eur. J. Org. Chem. 2019
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• Oxidoreductases: Providing Key Intermediates for Drug and Natural Product Synthesis, 02.2019
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• Photoredox/Rhodium Catalysis in C– H Activation for the Synthesis of Nitrogen Containing heterocycles. Org. Chem. Front. 2019, 6, 2319-2323
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• Regioselective Syntheses of 1,2-Benzothiazine 1-Imines by Rhodium-Catalyzed Annulation Reactions of Sulfondiimines. Adv. Synth. & Catal. 2019
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• Schwaneberg, U., Towards the Evolution of Artificial Metalloenzymes—A Protein Engineer's Perspective. Angew. Chem. Int. Ed. 2019, 58 (14), 4454-4464
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• Shake Flask Methodology for Assessing the Influence of the Maximum Oxygen Transfer Capacity on 2,3-Butanediol Production. Microb. Cell Fact. 2019, 18 (1), 78
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• Tailor-made polyγ-glutamic acid production. Metabolic Engineering 2019
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• Titanium Carbene Complexes Stabilized by Alkali Metal Amides. Angew. Chem. Int. Ed. 2019, 58 (6), 1833-1837
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• Transition Metal-Catalyzed Syntheses of Heterocycles and Sulfur-Containing Molecules, 07.2019
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• Tyrosinase Model Systems and Biohybrid Conjugates with Copper Bis(pyrazolyl)methane Complexes, 02.2019
  Liebhäuser, Patricia
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