Project Details
Projekt
Role of NF-kB in glomerulonephritis
Applicant
Professor Dr. Friedrich Thaiss
Subject Area
Nephrology
Term
from 2009 to 2016
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 101885864
Activation of the transcription factor NF-κB plays a pivotal role in inflammatory diseases by regulation of key mediators such as cytokines and chemokines. The central kinases in the multistep activation process of NF-κB are IKK2 (or IKKβ) and IKK1 (or IKKα). These kinases are therefore promising targets for pharmacological inhibition of NF-κB activation. IKK1 and IKK2 are dynamically activated and inactivated in the course of inflammation. Furthermore, they are differentially regulated in a cell lineage-specific manner. This project will concentrate on the analysis of cell-specific and time-dependent activation of NF-κB by IKK1 and IKK2 in an experimental model of crescentic glomerulonephritis. Understanding of the mechanisms that are relevant in differential activation of NF-κB in cell lineage specific leukocytes as well as in resident renal cells might be of great importance for future therapeutic strategies in patients with rapidly progressive glomerulonephritis.
DFG Programme
Clinical Research Units
