Entwicklung eines neuen Nanopartikel-basierten Impfstoffs zur Behandlung chronisch-persistierender Infektionen (C01)

• Subject Area: Virology
• Term: from 2009 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 47100475

In this project a nanoparticle-based vaccine that contains T cell epitope peptides and TLR ligands has been developed. Vaccination with this functionalized nanoparticles induced potent virus-specific T cell responses and reduced chronic retroviral loads in the Fried virus (FV) model. This very successful therapeutic vaccination shall now be combined with immune checkpoint blocking therapies to aim for virus elimination in FV infected mice. In addition, the nanoparticle vaccination strategy will be tested in the preclinical model of humanized BLT mice chronically infected with HIV-1. Clinically relevant delivery strategies (supporitories, oral administered capsules) will also be developed.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 60: Mutual Interaction of Viruses with Cells of the Immune System: From Fundamental Research to Immunotherapy and Vaccination
• Applicant Institution: Universität Duisburg-Essen
• Project Heads: Professor Dr. Jan Buer; Professor Dr. Matthias Epple; Professorin Dr. Astrid M. Westendorf