Impact of innate and adaptive immunity on Hepatitis C virus (HCV) infection and persistence
Final Report Abstract
The project had the goals to i) address vaccineinduced immunity in a mouse model for hepatitis C and ii) probe the human B cell repertoire for the presence of actively replicating HCV when co-infected with the humantropic Epstein-Barr virus. The data gained in this project taken together suggest that HCV infection of mice should be achievable by providing the required receptor and eventually blunting the innate antiviral response of the host. This would rank HCV close to other members of the Flaviviridae family that replicate poorly in fully immunocompetent animals (i.e. Dengue virus, Yellow fever virus). A remaining question that will need to be addressed is whether immunologically impaired mice that would potentially be able to replicate HCV would also show pathogenesis of the disease.
Publications
- (2011) A genetically humanized mouse model for Hepatitis C virus infection. Nature, 474(7350):208-11
Dorner, M., Horwitz, J.A., Robbins, J.B., Barry, W.T., Feng, Q., Mu, K., Jones, C.T., Schoggins, J.W., Catanese, M.T., Burton, D.R., Law, M., Rice, C.M. and Ploss, A.
(See online at https://doi.org/10.1038/nature10168) - (2012) Isolation and characterization of broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus. Proc. Natl. Acad. Sci. 109(16):6205-6210
Giang, E., Dorner, M., Prentoe, J., Dreux, M., Evans, M.J., Bukh, J., Rice, C.M., Ploss, A., Burton, D.R., and Law, M.
(See online at https://doi.org/10.1073/pnas.1114927109)
