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Spinal cord regeneration: comparative analysis of miRNA-regulated pathways in salamander spinal cord regeneration versus mammalian CNS injury repair
Antragstellerin
Professorin Elly Margaret Tanaka, Ph.D., seit 2/2012
Fachliche Zuordnung
Entwicklungsbiologie
Förderung
Förderung von 2009 bis 2016
Projektkennung
Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 157044246
Erstellungsjahr
2017
Zusammenfassung der Projektergebnisse
This work was one of the first studies to compare the microRNA transcriptional profile in the regenerative axolotl versus the non-regenerative rat after spinal cord injuries. It identified pathways that are differentially regulated in axolotl after spinal cord injury that promote a positive pro-generative circuitry to be activated and identified pathways that could be targeted in the non-regenerative rat to potentially promote better functional recovery after injury.
Projektbezogene Publikationen (Auswahl)
- Precise control of miR-125b levels is required to create a regeneration-permissive environment after spinal cord injury: a cross-species comparison between salamander and rat. Dis Model Mech. 2014 Jun;7(6):601-11
Diaz Quiroz JF, Tsai E, Coyle M, Sehm T, Echeverri K
(Siehe online unter https://doi.org/10.1242/dmm.014837)