Mechanisms underlying activation and polarisation of inflammatory monocytes and organ-specific regeneration in acute and chronic liver diseases (A02)

• Subject Area: Parasitology and Biology of Tropical Infectious Disease Pathogens
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 80750187

Inflammatory monocytes play a pivotal role in liver diseases ranging from the induction of immunopathology, as observed during infection with Entamoeba (E.) histolytica, to protection, as found in the Listeria infection model. We want to identify the molecular and immunological mechanisms responsible for liver-specific activation and polarisation of inflammatory monocytes in additional models for liver disease. Furthermore, we want to determine novel liver-specific repair mechanisms by analysing respective candidate genes expressed in the E. histolytica infection model during tissue repair.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 841: Liver Inflammation: Infection, Immune Regulation and Consequences
• Applicant Institution: Universität Hamburg
• Project Head: Professorin Dr. Hannelore Lotter