Regulatory T cells and TH17 cells in experimental cholangitis (B03)

• Subject Area: Gastroenterology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 80750187

The imbalance of regulatory T cells (Treg) and TH17 cells observed in patients with cholangitis offers the potential for therapeutic intervention. After having established a protocol to significantly expand Treg within the liver in vivo, we will now explore, how these hepatic Treg can be harnessed to become functionally active suppressors in cholangitis. Before IL-17 producing T cells can be targeted for treatment, their functional role in cholangitis needs to be defined. Using our antigen-dependent mouse models, we will investigate in detail the role of IL-17 producing CD8 and CD4 positive T cells in experimental cholangitis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 841: Liver Inflammation: Infection, Immune Regulation and Consequences
• Applicant Institution: Universität Hamburg
• Project Head: Professor Dr. Christoph Schramm