Phenotype and function of CD4+ T lymphocytes in autoimmune hepatitis (B05)

• Subject Area: Gastroenterology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 80750187

CD4+ T lymphocytes play a key role in pathogenesis of autoimmune hepatitis. We seek to characterize the phenotype and function of CD4+ T lymphocytes and to identify the autoantigen targeted by the T cells. As TNF secretion seems to characterize these pathogenic T-cells, we plan a clinical study using infliximab as a steroid-substitute in inducing remission in patients with newly diagnosed autoimmune hepatitis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 841: Liver Inflammation: Infection, Immune Regulation and Consequences
• Applicant Institution: Universität Hamburg
• Project Head: Dr. Christina Weiler-Normann