The role of anti-inflammatory bile acids for the development and progression of non-alcoholic steatohepatitis (NASH) (B06)

• Subject Area: Cell Biology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 80750187

Obesity-associated insulin resistance and hepatic lipid accumulation as a result of inactivity and high caloric intake are associated with the development of NASH. We want to investigate whether increased energy expenditure inhibits the progression of NASH through anti-inflammatory properties of bile acids generated via the alternative synthesis pathway. We want to study whether these effects depend either directly on anti-inflammatory signaling through the receptor TGR5 that is expressed on Kupffer cells, and/or indirectly on bioactive metabolites released by an altered gut microbiome.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 841: Liver Inflammation: Infection, Immune Regulation and Consequences
• Major Instrumentation: AB Sciex Qtrap
• Instrumentation Group: 1700 Massenspektrometer
• Applicant Institution: Universität Hamburg
• Project Head: Professor Dr. Jörg Heeren