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The Role of IL-6 and NASH in Hepatocellular Carcinoma (HCC) linked to Metabolic Disease (C03)

Subject Area Gastroenterology
Term from 2010 to 2021
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 80750187
 
The mechanism how NASH causes HCC is unknown. We and others show that IL-6 depletion causes liver steatosis and potentiates inflammation; on the other hand, IL-6 induces HCC in mice following administration of carcinogens. We wish to elucidate whether IL-6 plays a protective role against chronic liver injury associated with NAFLD, preventing HCC. Specifically, we wish: 1) to understand the potential role of the IL-6 pathway (signaling and transsignaling) in HCC development; 2) to determine the impact of diet-induced NAFLD on the IL-6 pathway in hepatocarcinogenesis; and 3) to assess novel therapeutic avenues to treat obesity-driven HCC.
DFG Programme Collaborative Research Centres
International Connection Israel
Applicant Institution Universität Hamburg
 
 

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