CRISPR/Cas-mediated genome editing for the study of processes involved in liver inflammation and its consequences (S02)

• Subject Area: Hematology, Oncology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 80750187

Functional gene analysis, particularly based on genome editing, will be crucial to study the role of individual genes and gene networks in all different phases of liver inflammation and its consequences. This service project will support members of CRC 841 in (i) performing CRISPR/Cas-based screening approaches, (ii) generating gene-edited cell lines, (iii) establishing (germ-line as well as liver-specific) “CRISPRed” mice, and (iv) permanent vector-based transgenesis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 841: Liver Inflammation: Infection, Immune Regulation and Consequences
• International Connection: Israel
• Applicant Institution: Universität Hamburg
• Project Heads: Professor Dr. Boris Fehse; Professor Dr. Eithan Galun