The control of vascular morphogenesis by neuronal guidance cues (A07)

• Subject Area: Anatomy and Physiology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 75732319

Vessels and nerves possess similar specialized structures that sense the surrounding tissue for specific cues that direct their movements. Our aim is to understand the function of neuronal cues in the patterning and signalling of the vasculature in the central nervous system. In this project, we focus on the role of the neuronal guiding molecules fibronectin-leucine-rich transmembrane proteins (FLRTs) which we have recently discovered to play a role during developmental angiogenesis. We will investigate the importance of FLRTs/Unc5 and latrophilins in regulating communication at the neurovascular unit in mouse and zebrafish.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 834: Endothelial Signalling and Vascular Repair
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professorin Dr. Amparo Acker-Palmer