Effect of chronic heart failure on the bone marrow vascular niche (B06)

• Subject Area: Cardiology, Angiology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 75732319

The vascular niche in the bone marrow plays a crucial role in maintenance and regulation of bone marrow cell function. Since heart failure compromises bone marrow cell function, we plan to investigate the effect of heart failure on bone marrow cell composition and on the vascular niche using newly available high-dimensional flow cytometry and bioinformatic analyses to compare the composition of various hematopoietic and niche cell types in bone marrow samples from patients with ischemic heart failure and healthy controls. Newly identified dysregulated pathways will be further studied with respect to their causal involvement.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 834: Endothelial Signalling and Vascular Repair
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Heads: Professorin Dr. Birgit Assmus; Dr. Jedrzej Hoffmann; Privatdozent Dr. Florian H. Seeger, until 12/2017; Professor Dr. Andreas Michael Zeiher