Mechanisms of Force Transduction across Talin to Integrin-Ligand Complexes (B03)

• Subject Area: Biophysics
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 111166240

Cells attachment to the extracellular matrix is mediated by integrins, which associate through Talin and Kindlin to the actomyosin cytoskeleton and thereby transduce actomyosin-induced forces to integrin ligand-bonds resulting in cell adhesion strengthening. We want to investigate how Talin and Kindlin bind to integrin cytoplasmic domains and how the new Talin-binding protein Kank regulates force transmission across Talin to integrins.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 863: Forces in Biomolecular Systems
• Applicant Institution: Technische Universität München (TUM)
• Project Head: Professor Dr. Reinhard Fässler